255893-38-0
Chemical Structure
SNAP8719 free base
- CAS No.: 255893-38-0
- Formula:C22H28F3N3O2
- Molecular Weight:423.47
IUPAC Name: (R)-8-(1-(4-(2,4,5-trifluorophenyl)piperazin-1-yl)propan-2-yl)-8-azaspiro[4.5]decane-7,9-dione
InChIKey: WCWNYVYNQAPOOX-OAHLLOKOSA-N
SMILES: O=C(N([C@H](C)CN1CCN(C2=CC(F)=C(F)C=C2F)CC1)C(C3)=O)CC43CCCC4
Biological Activity: SNAP8719 free base is a selective α1D-adrenoceptor antagonist (pKi = 8.89). SNAP8719 free base shows affinity for the dopamine D2-, 5-HT1A-, and the human clonal α2a-adrenoceptor, with pKi values of 5.98, 6.47, and <5.0, respectively. SNAP8719 free base causes a concentration-dependent increase in the twitch response[1].
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SNAP8719 free base | SNAP8719 free base is a selective α1D-adrenoceptor antagonist (pKi = 8.89). SNAP8719 free base shows affinity for the dopamine D2-, 5-HT1A-, and the human clonal α2a-adrenoceptor, with pKi values of 5.98, 6.47, and <5.0, respectively. SNAP8719 free base causes a concentration-dependent increase in the twitch response. | |||||||||||||||||||||
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Keywords
