1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Azepexole dihydrochloride

Azepexole dihydrochloride (Synonyms: B-HT 933 dihydrochloride; Oxazoloazepin dihydrochloride)

Cat. No.: HY-103212
Handling Instructions

Azepexole (B-HT 933) dihydrochloride is a potent and selective alpha 2-adrenoceptor agonist with pKis of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively. Azepexole dihydrochloride causes concentration-dependent inhibition of peristaltic contractions (IC50= 78.72 nM).

For research use only. We do not sell to patients.

Azepexole dihydrochloride Chemical Structure

Azepexole dihydrochloride Chemical Structure

CAS No. : 36067-72-8

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Description

Azepexole (B-HT 933) dihydrochloride is a potent and selective alpha 2-adrenoceptor agonist with pKis of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively[1]. Azepexole dihydrochloride causes concentration-dependent inhibition of peristaltic contractions (IC50= 78.72 nM)[2].

In Vitro

In normoglycemic rats, the sympathetically-induced vasopressor responses are dose-dependently inhibited by 1 and 3 μg/kg.min (i.v.) Azepexole dihydrochloride, with 10 and 30 μg/kg.min Azepexole dihydrochloride producing no further inhibition. In diabetic rats, the electrically-induced vasopressor responses are: (i) unchanged by 1 and 3 μg/kg.min Azepexole dihydrochloride; (ii) significantly inhibited at all frequencies of stimulation by 10 μg/kg.min B-HT 933 dihydrochloride; and (iii) similarly inhibited (i.e. supramaximal inhibition) by 30 μg/kg.min Azepexole dihydrochloride[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

254.16

Formula

C₉H₁₇Cl₂N₃O

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Azepexole dihydrochloride
Cat. No.:
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