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5-HETE

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By Targets:	Biochemical Assay Reagents (1) COX (1) Drug Isomer (1) Endogenous Metabolite (1) ERK (2) Lipoxygenase (3) NF-κB (2) Reference Standards (1)
By Research Areas:	Cardiovascular Disease (2) Endocrinology (1) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (2)

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Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0652

2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside 3 Publications Verification 2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside	ERK NF-κB	Cardiovascular Disease Neurological Disease
2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside isolats from the roots of Polygonaceae species, inhibits the formation of 5-HETE, HHT and thromboxane B2. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside has hypotensive, anti-ageing, anti-inflammatory, hypolipidemic, cardioprotective, and neuroprotective actions .

HY-113434B

*5-HETE* (±)-5-HETE	Endogenous Metabolite	Inflammation/Immunology
5-HETE ((±)-5-HETE), a fatty acid, is a oxidative derivative of Arachidonic acid. 5-HETE is a mixture of 5(S)-HETE and 5(R)-HETE. 5-HETE is a potent aggregating agent that induces the aggregation of neutrophils with an IC₅₀ value of 200 nM .

HY-113120

Stearidonic acid 6Z,9Z,12Z,15Z-Octadecatetraenoic acid	Lipoxygenase	Metabolic Disease
Stearidonic acid (6Z,9Z,12Z,15Z-Octadecatetraenoic acid) is an orally active polyunsaturated fatty acid found in blackcurrant seed oil. Stearidonic acid can inhibit *5-lipoxygenase* and reduce leukotriene and 5-HETE synthesis. Stearidonic acid can increase the content of eicosapentaenoic acid (EPA) in red blood cells. Stearidonic acid can be used for the research of metabolic disease .

HY-N0652R

2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Standard) 2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside (Standard)	Reference Standards ERK NF-κB	Cardiovascular Disease Neurological Disease
2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Standard) is the analytical standard of 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside. This product is intended for research and analytical applications. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside isolats from the roots of Polygonaceae species, inhibits the formation of 5-HETE, HHT and thromboxane B2. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside has hypotensive, anti-ageing, anti-inflammatory, hypolipidemic, cardioprotective, and neuroprotective actions .

HY-130220

*(±)5-HETE* lactone**	Drug Isomer	Inflammation/Immunology
(±)5-HETE lactone is the racemate of 5-HETE lactone. 5-HETE lactone is a metabolite generated by a series of enzymatic reactions of arachidonic acid, and is also a substrate of paraoxonase-1 (PON1). 5-HETE lactone can be used in the study of B cell activation .

HY-119671

BW 755C	COX Lipoxygenase	Endocrinology
BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC₅₀ of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC₅₀s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively .

HY-CE01484

5-Hete-CoA 5-Hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-coenzyme A	Biochemical Assay Reagents	Metabolic Disease
5-Hete-CoA (5-Hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-coenzyme A) is an unsaturated fatty acyl-CoA .

HY-182696

CGS 24891	Lipoxygenase	Inflammation/Immunology
CGS 24891 is an orally active 5-lipoxygenase (5-LO) inhibitor, with an IC₅₀ value of 0.051 μM in guinea pigs and 0.11 μM in dogs. CGS 24891 inhibits the production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B₄ (LTB₄) from arachidonic acid. CGS 24891 weakly inhibits 12-lipoxygenase (12-LO) with an IC₅₀ of 0.41 μM. CGS 24891 is applicable to research on inflammation and allergic reactions .

2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside 3 Publications Verification 2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside	Stilbenes Classification of Application Fields Polygonaceae Other Diseases Phenols Polyphenols Fallopia multiflora (Thunb.) Harald. Plants Disease Research Fields Source Classification	ERK NF-κB
2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside isolats from the roots of Polygonaceae species, inhibits the formation of 5-HETE, HHT and thromboxane B2. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside has hypotensive, anti-ageing, anti-inflammatory, hypolipidemic, cardioprotective, and neuroprotective actions .

*5-HETE* (±)-5-HETE	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
5-HETE ((±)-5-HETE), a fatty acid, is a oxidative derivative of Arachidonic acid. 5-HETE is a mixture of 5(S)-HETE and 5(R)-HETE. 5-HETE is a potent aggregating agent that induces the aggregation of neutrophils with an IC₅₀ value of 200 nM .

Stearidonic acid 6Z,9Z,12Z,15Z-Octadecatetraenoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Lipoxygenase
Stearidonic acid (6Z,9Z,12Z,15Z-Octadecatetraenoic acid) is an orally active polyunsaturated fatty acid found in blackcurrant seed oil. Stearidonic acid can inhibit *5-lipoxygenase* and reduce leukotriene and 5-HETE synthesis. Stearidonic acid can increase the content of eicosapentaenoic acid (EPA) in red blood cells. Stearidonic acid can be used for the research of metabolic disease .

2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Standard) 2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside (Standard)	Structural Classification Stilbenes Polygonaceae Phenols Polyphenols Fallopia multiflora (Thunb.) Harald. Plants Source Classification	Reference Standards ERK NF-κB
2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Standard) is the analytical standard of 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside. This product is intended for research and analytical applications. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside isolats from the roots of Polygonaceae species, inhibits the formation of 5-HETE, HHT and thromboxane B2. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside has hypotensive, anti-ageing, anti-inflammatory, hypolipidemic, cardioprotective, and neuroprotective actions .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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5-HETE

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