2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. COX Lipoxygenase
  4. BW 755C

BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC50s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively.

For research use only. We do not sell to patients.

BW 755C Chemical Structure

BW 755C Chemical Structure

CAS No. : 66000-40-6

Size Price Stock Quantity
5 mg USD 160 In-stock
10 mg USD 260 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

BW 755C Related Antibodies

Top Publications Citing Use of Products

View All COX Isoform Specific Products:

View All Isoforms
COX COX-1 COX-2 COX-3

View All Lipoxygenase Isoform Specific Products:

View All Isoforms
5-LOX 12-LOX 15-LOX

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC50s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively[1][2].

IC50 & Target[1][2]

5-LO

5 μM (IC50)

COX-1

0.65 μg/mL (IC50)

COX-2

1.2 μg/mL (IC50)

In Vivo

BW 755C (0.03-10 mg/rat; s.c.; once) inhibits the ovulation rate and ovarian levels of 5-HETE and 12-HETE in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Immature Wistar rats ~22 days of age[3]
Dosage: 0.03, 0.1, 0.3, 1.0, 3.1 and 10 mg/rat
Administration: Subcutaneous injection, once
Result: Reduced 5-HETE (moderately) and 12-HETE (strongly).
Molecular Weight

229.20

Formula

C10H10F3N3
CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

NC1=NN(C2=CC=CC(C(F)(F)F)=C2)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (436.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3630 mL 21.8150 mL 43.6300 mL
5 mM 0.8726 mL 4.3630 mL 8.7260 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

COA (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3630 mL 21.8150 mL 43.6300 mL 109.0750 mL
5 mM 0.8726 mL 4.3630 mL 8.7260 mL 21.8150 mL
10 mM 0.4363 mL 2.1815 mL 4.3630 mL 10.9075 mL
15 mM 0.2909 mL 1.4543 mL 2.9087 mL 7.2717 mL
20 mM 0.2182 mL 1.0908 mL 2.1815 mL 5.4538 mL
25 mM 0.1745 mL 0.8726 mL 1.7452 mL 4.3630 mL
30 mM 0.1454 mL 0.7272 mL 1.4543 mL 3.6358 mL
40 mM 0.1091 mL 0.5454 mL 1.0908 mL 2.7269 mL
50 mM 0.0873 mL 0.4363 mL 0.8726 mL 2.1815 mL
60 mM 0.0727 mL 0.3636 mL 0.7272 mL 1.8179 mL
80 mM 0.0545 mL 0.2727 mL 0.5454 mL 1.3634 mL
100 mM 0.0436 mL 0.2182 mL 0.4363 mL 1.0908 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

BW 755C Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BW 755C66000-40-6COXLipoxygenaseCyclooxygenaseLOX12-HETE5-HETEWistar ratInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
BW 755C
Cat. No.:
HY-119671
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.