66000-40-6
66000-40-6
Chemical Structure
BW 755C
- CAS No.: 66000-40-6
- Formula:C10H10F3N3
- Molecular Weight:229.20
IUPAC Name: 1-(3-(trifluoromethyl)phenyl)-4,5-dihydro-1H-pyrazol-3-amine
InChIKey: CPXGGWXJNQSFEP-UHFFFAOYSA-N
SMILES: NC1=NN(C2=CC=CC(C(F)(F)F)=C2)CC1
Biological Activity: BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC50s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BW 755C | 95.0% | BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC50s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively. | ||||||||||||||||||||
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References
- [1]. Hlasta DJ, et al. 5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones. J Med Chem. 1991 May;34(5):1560-70. [Content Brief]
- [2]. Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7. [Content Brief]
Keywords
