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Results for "

APR

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

1

Fluorescent Dye

1

Biochemical Assay Reagents

1

Peptides

3

Natural
Products

4

Recombinant Proteins

6

Antibodies

2

Oligonucleotides

1

GMP Molecules

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-19980
    Eprenetapopt
    10+ Cited Publications

    APR-246; PRIMA-1Met

    		 MDM-2/p53 Autophagy Apoptosis Ferroptosis Cancer
    Eprenetapopt (APR-246) is a first-in-class, small molecule that restores wild-type p53 functions in TP53-mutant cells. Eprenetapopt triggers apoptosis in tumor cells. Eprenetapopt also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance .
    Eprenetapopt
  • HY-P1788
    Influenza A NP(366-374) Strain A/PR/8/35

    		Influenza Virus Infection
    Influenza A NP(366-374) Strain A/PR/8/35 is an H2-Db-restricted epitope from Influenza A/PR/8/35 nucleoprotein .
    Influenza A NP(366-374) Strain A/PR/8/35
  • HY-N10843
    4-O-Methylepisappanol

    		Influenza Virus Infection
    4-O-Methylepisappanol (compound 9) is nature product that could be isolated from heartwood of Caesalpinia sappan. 4-O-Methylepisappanol is a potent neuraminidase inhibitor on the surface of influenza viruses with IC50 values of 42.8, 63.2, and 63.2 µM for A/Chicken/Korea/MS96/96 [H9N2], A/PR/8/34 [H1N1], and A/Hong Kong/8/68 [H3N2], respectively .
    4-O-Methylepisappanol
  • HY-19980G
    Eprenetapopt

    APR-246; PRIMA-1Met

    		 MDM-2/p53 Apoptosis Autophagy Ferroptosis Cancer
    Eprenetapopt (GMP) (APR-246(GMP)) is Eprenetapopt (HY-19980) in GMP grade. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Eprenetapopt (APR-246) is a first-in-class, small molecule that restores wild-type p53 functions in TP53-mutant cells. Eprenetapopt triggers apoptosis in tumor cells. Eprenetapopt also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance .
    Eprenetapopt
  • HY-RS10758
    PMAIP1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PMAIP1 Human Pre-designed siRNA Set A contains three designed siRNAs for PMAIP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PMAIP1 Human Pre-designed siRNA Set A
    PMAIP1 Human Pre-designed siRNA Set A
  • HY-N15618
    Antiviral agent 68

    		Influenza Virus Infection
    Antiviral agent 68 (Compound 3) is a diarylheptanoid that can be isolated from Alpinia katsumadai. Antiviral agent 68 has weak inhibitory activity against the neuraminidase of influenza virus A/PR/8/34, with an IC50 of 29.75 μM .
    Antiviral agent 68
  • HY-N9019
    1,4-Epidioxybisabola-2,10-dien-9-one

    		Influenza Virus Infection
    1,4-Epidioxybisabola-2,10-dien-9-one is a 1,4-epidioxy-bisabola-2,12-diene derivate, which can be isolated from Curcuma longa L. 1,4-Epidioxybisabola-2,10-dien-9-one exhibits antiviral activity against influenza virus A/PR/8/34 (H1N1) in the MDCK cell line with an IC50 of 16.79 ± 4.03 μg/mL .
    1,4-Epidioxybisabola-2,10-dien-9-one
  • HY-RS07792
    LRP1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    LRP1 Human Pre-designed siRNA Set A contains three designed siRNAs for LRP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    LRP1 Human Pre-designed siRNA Set A
    LRP1 Human Pre-designed siRNA Set A
  • HY-144668
    RdRP-IN-4

    		DNA/RNA Synthesis Influenza Virus Infection
    RdRP-IN-4 (compound 11q), an aryl benzoyl hydrazide analog, is an orally active influenza A virus RNA-dependent RNA polymerase (RdRp) inhibitor by interacting with the PB1 subunit. RdRP-IN-4 exhibits potent inhibitory activity against the avian H5N1 flu strain with an EC50 of 18 nM in MDCK cells. RdRP-IN-4 displays excellent potency against the the H1N1 (A/PR/8/34) Flu A strain and Flu B strain (B/Lee/1940) with EC50 values of 53 nM and 20 nM, respectively. RdRP-IN-4 significantly inhibits the expression level of viral nucleoprotein (NP) in a dose-dependent manner. RdRP-IN-4 exhibits significant antiviral activity in infected mice .
    RdRP-IN-4
  • HY-180269
    Anti-Influenza agent 10

    		Influenza Virus DNA/RNA Synthesis Infection
    Anti-Influenza agent 10 (Compound 41) is an influenza A virus RNA-dependent RNA polymerase (RdRp) inhibitor. Anti-Influenza agent 10 exhibits potent antiviral activity against A/PR/8/34(H1N1) with an IC50 of 0.29μM and a KD of 4.11 μM. Anti-Influenza agent 10 can inhibit the assembly of the viral RdRp complex by disrupting the protein interaction between PA and PB1 subunits, thereby blocking the transcription and replication of the viral genome. Anti-Influenza agent 10 shows significant broad-spectrum effects on multiple influenza virus strains, such as H3N2, H3N8 and H9N2 with IC50 values of 3.96, 1.91 and 1.45 μM. Anti-Influenza agent 10 can be used for the research of influenza A Virus Infection .
    Anti-Influenza agent 10

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