LRP1 Antibody (YA6261)
(Synonyms: LRP1; A2MR; APR; Prolow-density lipoprotein receptor-related protein 1; LRP-1; Alpha-2-macroglobulin receptor; A2MR; Apolipoprotein E receptor; APOER; CD antigen CD91)LRP1 Antibody (YA6261) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LRP1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, IP, ELISA
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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IP
IP: Immunoprecipitation
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|---|---|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:1000-1:5000 | 1:200-1:1000 | 1:5000-1:20000 | 1:50-1:200 |
Product Details
LRP1 Antibody (YA6261) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LRP1.
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Host Rabbit
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 85 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 85 kDa
Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic and signaling receptor of the LDL receptor family that regulates lipoprotein metabolism, protease clearance, cellular signaling, and tissue homeostasis across multiple organ systems[1][2]. Mechanistically, LRP1 couples rapid ligand internalization with signal transduction, allowing coordinated control of extracellular protein turnover and intracellular responses involved in cell survival, migration, inflammation, and vascular biology[1][2]. Through its broad ligand repertoire, LRP1 participates in key biological processes including endocytosis, phagocytosis, and receptor-mediated clearance pathways that maintain physiological balance in the liver, vasculature, and central nervous system[1][2]. In disease contexts, LRP1 has been extensively studied in neurodegenerative disorders because it contributes to amyloid-β (Aβ) homeostasis through cellular uptake, lysosomal trafficking, and clearance mechanisms[3][4]. Experimental evidence demonstrates that LRP1-mediated endocytosis promotes neuronal Aβ42 uptake and accumulation within lysosomal compartments, highlighting a central role in neuronal Aβ metabolism[3]. LRP1 is also implicated in vascular disease, inflammation, and tissue remodeling through its ability to integrate endocytic and signaling functions within a single receptor system[1][2]. Compared with related LDL receptor family members, LRP1 is distinguished by its exceptionally broad ligand-binding capacity and dual role as both a scavenger receptor and signaling receptor, enabling regulation of diverse physiological pathways[1][2]. Consequently, genetic manipulation of LRP1 has become a widely used experimental approach for investigating receptor-mediated transport, neurodegeneration, vascular biology, and cell-signaling mechanisms[1][3][4].
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Membrane, coated pit; Cell membrane; Peripheral membrane protein; Extracellular side; Membrane, coated pit; Cytoplasm; Nucleus; Golgi outpost; Cytoplasm, cytoskeleton, microtubule organizing center
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Expression
Tissue_specificity:It is most abundant in the liver, brain, and lungs. -
Isoforms & Post-Translational Modification
Q07954 has 2 isomers: Q07954-1: 504606 Da (predicted); Q07954-2: 31631 Da (predicted).
Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane;The N-terminus is blocked;Phosphorylated on serine and threonine residues;Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1 -
Subunit
Heterodimer of an 85-kDa membrane-bound carboxyl subunit and a non-covalently attached 515-kDa N-terminal subunit. Intracellular domain interacts with MAFB (By similarity). Found in a complex with PID1/PCLI1, LRP1 and CUBNI (PubMed:17124247). Interacts with SNX17, PID1/PCLI1, PDGF and CUBN. The intracellular domain interacts with SHC1, GULP1 and DAB1. Can weakly interact (via NPXY motif) with DAB2 (via PID domain); the interaction is enhanced by tyrosine phosphorylation of the NPXY motif. Interacts with MDK; promotes neuronal survival (PubMed:10772929). Interacts with LRPAP1; this interaction is followed by rapid internalization (PubMed:15053742, PubMed:16938309, PubMed:32296178). Interacts with uPA/PLAU and PAI1/SERPINE1, either individually or in complex with each other, leading to rapid endocytosis; this interaction is abolished in the presence of LRPAP1/RAP (PubMed:1423604, PubMed:15053742). Also interacts with tPA/PLAT alone or in complex with SERPINE1 (PubMed:15053742). Interacts with the urokinase receptor PLAUR; this interaction leads to PLAUR internalization and is impaired in the presence of SORL1 (PubMed:14764453). Interacts with PDGFB (PubMed:15053742). Interacts with TAU/MAPT, leading to endocytosis; this interaction is reduced in the presence of LRPAP1/RAP (PubMed:32296178). Interacts with IGFBP3; this interaction mediates cell growth inhibition independently of IGF1 (PubMed:9252371). Interacts with ADGRG6 (By similarity)
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SwissProt ID
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Synonyms
LRP1; A2MR; APR; Prolow-density lipoprotein receptor-related protein 1; LRP-1; Alpha-2-macroglobulin receptor; A2MR; Apolipoprotein E receptor; APOER; CD antigen CD91
Documentation
[1]. Strickland DK, et al. Low-density lipoprotein receptor-related protein-1: role in the regulation of vascular integrity. Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):487-98. [Content Brief]
[2]. Fuentealba RA, et al. Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking. PLoS One. 2010 Jul 29;5(7):e11884. [Content Brief]
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