LRP1 - LDL receptor related protein 1 Gene

Also Known as APR; KPA; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R; IGFBP-3R; IGFBP3R1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4035

About LRP1

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:57,128,483-57,213,361 (from NCBI)

This gene has 12 transcripts (splice variants), 270 orthologues, 14 paralogues and is associated with 3 phenotypes. Ubiquitous expression in fat (RPKM 73.6), ovary (RPKM 50.9) and 22 other tissues.

Summary

This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by Furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]

LRP1 Products (1)

mRNA	Protein	Name
NM_002332.3	NP_002323.2	prolow-density lipoprotein receptor-related protein 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables alpha-2 macroglobulin receptor activity	IMP IMP: Inferred from mutant phenotype	26142438	GOA
enables apolipoprotein binding	IDA IDA: Inferred from direct assay	2779654	GOA
enables apolipoprotein binding	IPI IPI: Inferred from physical interaction	18635818	GOA
enables cargo receptor activity	IMP IMP: Inferred from mutant phenotype	23152628	GOA
enables clathrin heavy chain binding	IPI IPI: Inferred from physical interaction	26005850	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8626514	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	8626514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in amyloid-beta clearance by cellular catabolic process	IMP IMP: Inferred from mutant phenotype	23152628	GOA
involved in amyloid-beta clearance by transcytosis	IGI IGI: Inferred from genetic interaction	26005850	GOA
involved in phagocytosis	IMP IMP: Inferred from mutant phenotype	23152628	GOA
involved in positive regulation of endocytosis	IGI IGI: Inferred from genetic interaction	23386614	GOA
involved in positive regulation of lysosomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	23152628	GOA
involved in positive regulation of protein binding	IGI IGI: Inferred from genetic interaction	23386614	GOA
involved in positive regulation of protein localization to plasma membrane	IGI IGI: Inferred from genetic interaction	23386614	GOA
involved in receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	23152628	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	26005850	GOA
located in early endosome	IDA IDA: Inferred from direct assay	26005850	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRP1 Protein Structure

Ldl_recept_a

EGF_CA

Ldl_recept_b

FXa_inhibition

Ldl_recept_a

FXa_inhibition

Ldl_recept_b

Ldl_recept_a

cEGF

Ldl_recept_b

FXa_inhibition

Ldl_recept_a

Ldl_recept_b

0
700
1400
2100
2800
3500
4200
4544 a.a.

Protein Preferred Names	Protein Names
prolow-density lipoprotein receptor-related protein 1	TbetaR-V/LRP-1/IGFBP-3 receptor

LRP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LRP1	Q07954	APOE	Homo sapiens	P02649	SPR	15182176
Intra	LRP1	Q07954	APOE	Homo sapiens	P02649	Pull Down	15182176
Intra	LRP1	Q07954	APOE	Homo sapiens	P02649	Anti Tag CoIP	15182176
Intra	LRP1	Q07954	APOE	Homo sapiens	P02649	SPR	20030366
Intra	LRP1	Q07954	APOE	Homo sapiens	P02649	Pull Down	20030366
Intra	LRP1	Q07954	APOE	Homo sapiens	P02649	NMR	20030366
Cross	LRP1	Q07954	Thbs2	Mus musculus	Q03350	Anti Tag CoIP	20472562
Intra	LRP1	Q07954	MBL2	Homo sapiens	P11226	ELISA	21054788
Intra	LRP1	Q07954	MBL2	Homo sapiens	P11226	SPR	21054788
Intra	LRP1	Q07954	LRPAP1	Homo sapiens	P30533	Pull Down	20030366
Intra	LRP1	Q07954	LRPAP1	Homo sapiens	P30533	SPR	17326667
Intra	LRP1	Q07954	FCN2	Homo sapiens	Q15485	ELISA	21054788
Intra	LRP1	Q07954	FCN2	Homo sapiens	Q15485	SPR	21054788
Intra	LRP1	Q07954	APBB1	Homo sapiens	O00213	Pull Down	21968187
Cross	LRP1	Q07954	Jag1	Rattus norvegicus	Q63722	Anti Tag CoIP	20472562

Cross: Cross-species interaction Intra: Intraspecies interaction

LRP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80746	LRP1 Antibody (YA306)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P80746A	LRP1 Antibody (YA306)(PBS only)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P86569	LRP1 Antibody (YA6261)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Keratosis Pilaris Atrophicans	KPA Burnett Schwartz Berberian Syndrome
Atrophoderma Vermiculata	Atrophoderma Vermiculatum Folliculitis Ulerythematosa Reticulata Atrophodermia Vermiculata Honeycomb Atrophy Atrophodermia Reticulata Symmetrica Faciei AVA Atrophodermia Reticulata Folliculitis Ulerythematosa Folliculitis Ulerythematosa Reticulate Burnett Schwartz Berberian Syndrome
Keratosis Follicularis Spinulosa Decalvans	Kfsd Keratosis Follicularis Spinulosa Decalvans Cum Ophiasi Keratosis Follicularis Spinulosa Decalvans, X-Linked Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant
Keratosis Pilaris Atrophicans Faciei
Rift Valley Fever	Rfv - [Rift Valley Fever]
Cerebral Amyloid Angiopathy, Cst3-Related	Cerebral Amyloid Angiopathy Hereditary Cerebral Hemorrhage With Amyloidosis Hchwa Hereditary Cystatin C Amyloid Angiopathy Cerebral Amyloid Angiopathy, Familial Amyloidosis, Cerebroarterial, Icelandic Type Amyloidosis Vi Cerebral Hemorrhage, Hereditary, With Amyloidosis Cst3-Related Cerebral Amyloid Angiopathy Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant Caa, Familial Cerebral Amyloid Angiopathy, Genetic Acys Amyloidosis Cst3-Related Amyloidosis Cystatin Amyloidosis Hchwa, Icelandic Type Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type Amyloidosis 6 AMYL6 Acys Caa Cerebral Amyloid Angiopathy Cst3-Related Cerebroarterial Amyloidosis Icelandic Type Cystatin C Amyloidosis Hccaa Hchwai Hchwa-I Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type Cerebral Amyloid Angiopathy Familial Angiopathy, Amyloid, Cerebral, Cst3-Related Hereditary Cerebral Amyloid Angiopathy, Icelandic Type Familial Cerebral Amyloid Angiopathy Cerebral Amyloid Angiopathy, Hereditary
Keratosis	Actinic Keratosis Hyperkeratosis
Familial Hyperlipidemia	Familial Hyperlipoproteinemia Hyperlipidaemia Hyperlipoproteinemias Hyperlipidemia Hyperlipemia Hyperlipidemias
Migraine Without Aura	Common Migraine Migraine With Or Without Aura, Susceptibility To Migraine Without Aura, Susceptibility To Acute Migraine Without Aura
Liposarcoma	Lipomatous Cancer
Amyloidosis	Amyloid Disease Amyloid Amyloid Degeneration Amyloidosis Nos Amyloid Deposition Amyloid Infiltration Idiopathic Amyloidosis Hyaloid Degeneration Lardaceous Degeneration
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Familial Hypercholesterolemia	Hyperlipoproteinemia Type Iia Familial Hyperbetalipoproteinaemia Familial Hypercholesteremia Fredrickson Type Iia Hyperlipoproteinemia Fredrickson Type Iia Lipidaemia Hyperbetalipoproteinemia Type Ii Hyperlipidemia Familial Hypercholesterolæmia Familial Hypercholesterolaemia Fh Hypercholesterolemia Familial Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial
Aortic Aneurysm	Aortic Rupture Thoracoabdominal Aortic Aneurysm, Ruptured Ruptured Aortic Aneurysm Aortic Aneurysms Aortic Aneurysm Without Mention Of Rupture Nos Ruptured Abdominal Aortic Aneurysm Aortic Aneurysm, Ruptured Ruptured Thoracic Aortic Aneurysm
Cerebral Amyloid Angiopathy, App-Related	Hchwad Amyloidosis, Cerebroarterial, App-Related Amyloidosis, Hereditary, With Cerebral Hemorrhage, Dutch Variant Cerebral Amyloid Angiopathy, App-Related, Dutch Variant Cerebral Amyloid Angiopathy, App-Related, Iowa Variant Cerebral Amyloid Angiopathy, App-Related, Italian Variant Cerebral Amyloid Angiopathy, App-Related, Flemish Variant Cerebral Amyloid Angiopathy, App-Related, Arctic Variant Cerebral Amyloid Angiopathy, Dutch, Italian, Iowa, Flemish, Arctic Variants App-Related Cerebral Amyloid Angiopathy Abetaa21g Amyloidosis Abeta Amyloidosis, Italian Type Abeta Amyloidosis, Arctic Type Abeta Amyloidosis, Iowa Type Abeta Amyloidosis, Dutch Type Hchwa-D Abeta Amyloidosis, Flemish Type Abetaa21g-Related Amyloidosis Hchwa, Flemish Type Hereditary Cerebral Hemorrhage With Amyloidosis, Flemish Type Abetae22k Amyloidosis Hchwa, Italian Type Hereditary Cerebral Hemorrhage With Amyloidosis, Italian Type Abetae22g Amyloidosis Hchwa, Arctic Type Hereditary Cerebral Hemorrhage With Amyloidosis, Arctic Type Abetad23n Amyloidosis Hchwa, Iowa Type Hereditary Cerebral Hemorrhage With Amyloidosis, Iowa Type Abetal34v Amyloidosis Abeta Amyloidosis, Piedmont Type Abetal34v-Related Amyloidosis Hchwa, Piedmont Type Hereditary Cerebral Hemorrhage With Amyloidosis, Piedmont Type Abetae22q Amyloidosis Hchwa, Dutch Type Hereditary Cerebral Hemorrhage With Amyloidosis, Dutch Type CAA-APP Amyloidosis Cerebroarterial App-Related Amyloidosis Hereditary With Cerebral Hemorrhage Dutch Variant Cerebral Amyloid Angiopathy App-Related Arctic Variant Cerebral Amyloid Angiopathy App-Related Dutch Variant Cerebral Amyloid Angiopathy App-Related Flemish Variant Cerebral Amyloid Angiopathy App-Related Iowa Variant Cerebral Amyloid Angiopathy App-Related Italian Variant Familial Occipital Calcifications With Hemorrhagic Strokes Leukoencephalopathy Arterial Dysplasia Dementia Fochs-Ladd Hereditary Cerebral Amyloid Angiopathy Dutch Type Hereditary Cerebral Hemorrhage With Amyloidosis Dutch Type Hereditary Cerebral Hemorrhage With Amyloidosis Italian Type Cerebral Hemorrhage With Amyloidosis, Hereditary, Dutch Type
Marfan Syndrome	MFS Mfs1 Marfan'S Syndrome Marfan Syndrome Type 1 Marfan Syndrome, Type I Mass Phenotype Contractural Arachnodactyly Mass Syndrome Octd Overlap Connective Tissue Disease Marfanoid Hypermobility Syndrome Marfan Disease
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Familial Thoracic Aortic Aneurysm Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P4073	ANG1005		98.83%	Phase 3

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100447	TM5275 sodium	Inhibitor	98.97%	Unkown
HY-P10502A	L57 acetate		99.01%	Unkown
HY-P10502	L57		99.44%	Unkown
HY-172699A	DSPE-PEG3400-ANG		95.0%	Unkown
HY-165426	HB-230		/	Unkown
HY-N9454	Garcinoic acid		/	Unkown
HY-RS23105	Lrp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-183626	PAI-1-IN-1		99.45%	Unkown
HY-172698	DSPE-PEG1000-ANG		/	Unkown
HY-172699	DSPE-PEG2000-ANG		/	Unkown
HY-172700	DSPE-PEG5000-ANG		/	Unkown
HY-179459	SJ-300	Inhibitor	/	Unkown
HY-P10911	IETP2	Ligand	/	Unkown
HY-RS01706	C1D Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07792	LRP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07796	LRP1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-183877	YO-2		/	Unkown
HY-RS16670	Lrp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29133	Lrp1b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990202	Anti-Mouse/Rat/Human LRP1/CD91 Antibody (11H4)	Inhibitor	≥95.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LRP1	VGNC	VGNC:42771
Rattus norvegicus	LRP1	RGD	RGD:1307535
Felis catus	LRP1	VGNC	VGNC:68087
Macaca mulatta	LRP1	VGNC	VGNC:74442
Bos taurus	LRP1	VGNC	VGNC:30986
Mus musculus	LRP1	MGD	MGI:96828
Others	LRP1	NCBI