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Cat. No.: HY-190882

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SBI-2771

SBI-2771 is an LRP1-BD4 inhibitor that blocks the interaction between the LRP1 ligand-binding domain and tau and L57 peptide. SBI-2771 reduces tau uptake in glioma cells. SBI-2771 can be used for research on Alzheimer's disease.

For research use only. We do not sell to patients.

CAS No.: 354536-59-7
Formula: C₁₁H₅Cl₂F₄N₃O₂S
Molecular Weight:390.14

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

SBI-2771 Chemical Structure

CAS No.: 354536-59-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

LRP1-BD4

In Vitro

Aβ/Tau/α-Synuclein AggregationLysosomal MetabolismAnti-cancerOthers

Aβ/Tau/α-Synuclein Aggregation

SBI-2771 (0.01-100 μM) inhibits LRP1-BD4-tau NanoLuc complementation with an IC₅₀ of 6.9 μM^[1].

Aβ/Tau/α-Synuclein Aggregation

Lysosomal Metabolism

Anti-cancer

SBI-2771 (0.01-100 μM; 1 h) reduces tau-647 uptake in H4 glioma cells with an IC₅₀ of 54 μM^[1].

Others

SBI-2771 (0.01-100 μM) inhibits the LRP1-BD4-Biotin-L57 TR-FRET interaction with an IC₅₀ of 4.5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Alzheimer’s Disease Modeling

Chemical Information

CAS No. 354536-59-7
Molecular Weight 390.14
Formula C₁₁H₅Cl₂F₄N₃O₂S
SMILES

ClC1=C(Cl)C=C(NC(NC(SC2(C(F)(F)F)F)=NC2=O)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang C, et al. High-Throughput Screening Identifies Small-Molecule Inhibitors of the Tau-LRP1 Interaction. bioRxiv [Preprint]. 2026 Sep 2:2026.06.24.733881.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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