Jag1 - jagged canonical Notch ligand 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29146

Summary

Enables Notch binding activity and receptor ligand activity. Involved in several processes, including animal organ regeneration; inner ear auditory receptor cell differentiation; and positive regulation of cardiac epithelial to mesenchymal transition. Located in plasma membrane. Human ortholog(s) of this gene implicated in Alagille syndrome; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1). [provided by Alliance of Genome Resources, Apr 2022]

Jag1 Products (1)

mRNA Protein Name
NM_019147.2 NP_062020.2 protein jagged-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables Notch binding IPI
IPI: Inferred from physical interaction
28089369 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
20145246 RGD
enables receptor ligand activity IDA
IDA: Inferred from direct assay
7697721 RGD
Biological Process GO Annotation Evidence References Source
involved in Notch signaling pathway IDA
IDA: Inferred from direct assay
7697721 RGD
involved in Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
15057910 RGD
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
15057910 RGD
involved in inner ear auditory receptor cell differentiation IMP
IMP: Inferred from mutant phenotype
10887092 RGD
involved in negative regulation of cell differentiation IDA
IDA: Inferred from direct assay
7697721 RGD
involved in positive regulation of cardiac epithelial to mesenchymal transition IGI
IGI: Inferred from genetic interaction
20951801 RGD
involved in positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
20951801 RGD
involved in regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15057910 RGD
involved in wound healing IEP
IEP: Inferred from expression pattern
11549580 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein jagged-1

  • jagged 1

Jag1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Jag1 Q63722 LRP1 Homo sapiens Q07954
Anti Tag CoIP
20472562
Cross
Jag1 Q63722 Thbs2 Mus musculus Q03350
Anti Tag CoIP
20472562
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1846A Jagged-1 (188-204) TFA Agonist 99.89% Unkown
HY-P1846 Jagged-1 (188-204) Agonist 99.72% Unkown
HY-P1849A JAG-1, scrambled TFA Control 99.75% Unkown
HY-RS16717 Jag1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07012 JAG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23152 Jag1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991860 Anti-JAG1/CD339 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jag1 NCBI NCBI:182