NOXA Antibody (YA9675)
(Synonyms: Adult T cell leukemia derived PMA responsive, APR, APR_HUMAN, ATL-derived, Immediate early response protein APR, Immediate-early-response protein APR, NOXA, Phorbol 12 myristate 13 acetate induced protein 1, Phorbol-12-myristate-13-acetate-induced protein 1, PMA induced protein 1)NOXA Antibody (YA9675) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to NOXA.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500 | 1:8000 |
Product Details
NOXA Antibody (YA9675) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to NOXA.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 6 kDa;
Synthetic peptide of Human Noxa (aa 5-54).
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NOXA promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1
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Subcellular Localization
Mitochondrion
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Expression
Tissue_Specificity: Highly expressed in adult T-cell leukemia cell line.
Induction: Up-regulated by p53/TP53, phorbol esters, double-stranded RNA, IFNB1/IFN-beta and viruses. -
Isoforms & Post-Translational Modification
NOXA has 2 isoforms, Q13794-1: amino acid length is 54, molecular weight is 6030 Da (predicted); Q13794-2: amino acid length is 136, molecular weight is 14955 Da (predicted).
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Subunit
Interacts with MCL1.
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SwissProt ID
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Synonyms
Adult T cell leukemia derived PMA responsive, APR, APR_HUMAN, ATL-derived, Immediate early response protein APR, Immediate-early-response protein APR, NOXA, Phorbol 12 myristate 13 acetate induced protein 1, Phorbol-12-myristate-13-acetate-induced protein 1, PMA induced protein 1
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