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NOXA Antibody (YA2553)(PBS only)

(Synonyms: APR; ATL-derived; NOXA; Pmaip1; Protein Noxa)

NOXA Antibody (YA2553) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NOXA.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • NOXA Antibody (YA2553)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:1000-1:5000

Product Details

Description

NOXA Antibody (YA2553) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NOXA.

  • Host Rabbit
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 10 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 6 kDa
Immunogen

A synthetic peptide of human Noxa

Purification

Affinity Purified

Conjugation

Non-conjugated

Isotype

IgG

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    NOXA promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1

  • Subcellular Localization

    Mitochondrion

  • Expression


    Tissue_specificity:Highly expressed in adult T-cell leukemia cell line

    Induction:Up-regulated by p53/TP53, phorbol esters, double-stranded RNA, IFNB1/IFN-beta and viruses

  • Isoforms & Post-Translational Modification

    Q13794 has 2 isomers: Q13794-1: 6030 Da (predicted); Q13794-2: 14955 Da (predicted).

  • Subunit

    Interacts with MCL1 (PubMed:15694340, PubMed:17374615, PubMed:17389404). Interacts with BCL2A1 (Ref.11). Interacts with BAX (PubMed:15705586). Interacts with BCL2L10 (PubMed:23563182)

  • SwissProt ID

    Q13794

  • Gene ID
    5366 [NCBI]
  • Synonyms

    APR; ATL-derived; NOXA; Pmaip1; Protein Noxa

  • Research Field

    Cell Biology

NOXA Antibody (YA2553)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • NOXA Antibody (YA2553)(PBS only) Product Image