NOXA Antibody (YA2553)(PBS only)

Cat. No.: HY-P82808A: Data Sheet User Guide for Antibodies
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NOXA Antibody (YA2553) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NOXA.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

NOXA Antibody (YA2553) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NOXA.

Host

Rabbit

Molecular Weight

Predicted band size: 6 kDa;

Observed band size: 10 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q13794

Gene ID

5366 [NCBI]

Immunogen

A synthetic peptide of human Noxa

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-1:5000

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1

Subcellular Localization：Mitochondrion

Expression：
Tissue_specificity:Highly expressed in adult T-cell leukemia cell line

Induction:Up-regulated by p53/TP53, phorbol esters, double-stranded RNA, IFNB1/IFN-beta and viruses

Isoforms & Post-Translational Modification：Q13794 has 2 isomers: Q13794-1: 6030 Da (predicted); Q13794-2: 14955 Da (predicted).

Subunit：Interacts with MCL1 (PubMed:15694340, PubMed:17374615, PubMed:17389404). Interacts with BCL2A1 (Ref.11). Interacts with BAX (PubMed:15705586). Interacts with BCL2L10 (PubMed:23563182)

Research Field

Cell Biology

Synonyms

APR; ATL-derived; NOXA; Pmaip1; Protein Noxa

Documentation

User Guide for Antibodies (1077 KB)