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Acetylcholinesterase, Electric eel

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製品番号 製品名 Target 研究分野 構造式
  • HY-P2860A
    Acetylcholinesterase, Electric eel

    		Cholinesterase (ChE) Neurological Disease
    Acetylcholinesterase, Electric eel is a cholinergic enzyme that is mainly found in neuromuscular junctions and cholinergic chemical synapses and is often used in biochemical research. Acetylcholinesterase, Electric eel can catalyze the decomposition or hydrolysis of acetylcholine and some other choline esters that act as neurotransmitters into acetic acid and choline. The main function of Acetylcholinesterase, Electric eel is to terminate neuronal transmission and signal conduction between synapses to prevent ACh diffusion and activation of nearby receptors .
    Acetylcholinesterase, Electric eel
  • HY-110389
    Pitofenone hydrochloride

    		Cholinesterase (ChE) Neurological Disease
    Pitofenone hydrochloride, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 36 and 45 μM, respectively .
    Pitofenone hydrochloride
  • HY-105853
    Pitofenone

    		Cholinesterase (ChE) Neurological Disease
    Pitofenone, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 36 and 45 μM, respectively .
    Pitofenone
  • HY-105853S
    Pitofenone-d4

    		Isotope-Labeled Compounds Neurological Disease
    Pitofenone-d4 is deuterium labeled Pitofenone (HY-105853). Pitofenone, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 36 and 45 μM, respectively .
    Pitofenone-d4
  • HY-N7263
    Galanthamine N-Oxide

    		Cholinesterase (ChE) Neurological Disease
    Galanthamine N-Oxide is an alkaloid obtained from the bulbs of Zephyranthes concolor. Galanthamine N-Oxide inhibits electric eel acetylcholinesterase (AChE) with an EC50 of 26.2 μM. Galanthamine N-Oxide is a prominent inhibitor of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes .
    Galanthamine N-Oxide
  • HY-146035
    AChE-IN-14

    		Cholinesterase (ChE) Histamine Receptor Neurological Disease
    AChE-IN-14 (compound 5) is a potent cholinesterase inhibitor with IC50s of 0.46 , 0.48, and 0.44 μM for electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hAChE), and equine serum butyrylcholinesterase (eqBuChE), respectively. AChE-IN-14 exhibits high affinity toward human H3 receptor (H3R; Ki= 159.8 nM). AChE-IN-14 can be used for the research of Alzheimer’s disease .
    AChE-IN-14
  • HY-144790
    AChE-IN-12

    		Amyloid-β Cholinesterase (ChE) Monoamine Oxidase Neurological Disease
    AChE-IN-12 is a potent and blood-brain barrier (BBB) penetrant acetylcholinesterase (AChE) with IC50s of 0.41 μM and 1.88 μM for rat AChE and electric eel AChE. AChE-IN-12 is also a good antioxidant (ORAC = 3.3 eq), selective metal chelator and huMAO-B inhibitor (IC50 = 8.8 μM). AChE-IN-12 has remarkable inhibition of self- and Cu 2+-induced Aβ1-42 aggregation, as well as exhibits a good neuroprotective effect. AChE-IN-12 can be used for researching Alzheimer’s disease .
    AChE-IN-12
  • HY-185346
    AChE-IN-113

    		Cholinesterase (ChE) Neurological Disease
    AChE-IN-113 is a selective acetylcholinesterase inhibitor with a Ki value of 8.3 μM against electric eel acetylcholinesterase. AChE-IN-113 can be used for the research of Alzheimer's disease .
    AChE-IN-113
  • HY-N19855
    Merulinic acid

    Geranicardic acid

    		 Cholinesterase (ChE) Neurological Disease
    Merulinic acid (Geranicardic acid) is an acetylcholinesterase (AChE) inhibitor with an IC50 >94 μM against electric eel-derived AChE. Merulinic acid can be used for the research of alzheimer’s disease .
    Merulinic acid
  • HY-183303
    AChE-IN-116

    		Cholinesterase (ChE) Reactive Oxygen Species (ROS) Neurological Disease
    AChE-IN-116 is a selective acetylcholinesterase (AChE) inhibitor with an electric eel AChE IC50 of 1.60 μM and Ki of 1.72 μM. AChE-IN-116 exhibits weak ability to scavenge DPPH radical. AChE-IN-116 can be used for the research of Alzheimer's disease .
    AChE-IN-116
  • HY-181161
    AChE-IN-107

    		Cholinesterase (ChE) Neurological Disease
    AChE-IN-107 is a selective acetylcholinesterase (AChE) inhibitor with an IC50 of 0.22 μM and a Ki of 0.207 μM. AChE-IN-107 shows no inhibitory effect on equine serum BChE at 10 μM. AChE-IN-107 exhibits mixed-type inhibition of electric eel acetylcholinesterase, binding to both free enzyme and enzyme-substrate complex. AChE-IN-107 acts as a cytotoxin, reduces cell viability in hepatocellular carcinoma HepG2 cells.AChE-IN-107 can be used for the research of alzheimer's disease .
    AChE-IN-107

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