2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. AChE-IN-107

AChE-IN-107 is a selective acetylcholinesterase (AChE) inhibitor with an IC50 of 0.22 μM and a Ki of 0.207 μM. AChE-IN-107 shows no inhibitory effect on equine serum BChE at 10 μM. AChE-IN-107 exhibits mixed-type inhibition of electric eel acetylcholinesterase, binding to both free enzyme and enzyme-substrate complex. AChE-IN-107 acts as a cytotoxin, reduces cell viability in hepatocellular carcinoma HepG2 cells.AChE-IN-107 can be used for the research of alzheimer's disease.

For research use only. We do not sell to patients.

AChE-IN-107

AChE-IN-107 Chemical Structure

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AChE-IN-107 Related Antibodies

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Description

AChE-IN-107 is a selective acetylcholinesterase (AChE) inhibitor with an IC50 of 0.22 μM and a Ki of 0.207 μM. AChE-IN-107 shows no inhibitory effect on equine serum BChE at 10 μM. AChE-IN-107 exhibits mixed-type inhibition of electric eel acetylcholinesterase, binding to both free enzyme and enzyme-substrate complex. AChE-IN-107 acts as a cytotoxin, reduces cell viability in hepatocellular carcinoma HepG2 cells.AChE-IN-107 can be used for the research of alzheimer's disease[1].

IC50 & Target[1]

AChE

0.22 μM (IC50)

AChE

0.207 μM (Ki)

In Vitro

AChE-IN-107 (compound 22) binds to the CAS of hAChE with favorable energy and key interactions with Trp86, Tyr133, and Tyr337[1].
AChE-IN-107 has favorable ADMET properties including predicted blood-brain barrier penetration and low liver injury risk (class I)[1].
AChE-IN-107 (0.005-100.0 μM; 48 h) exhibits moderate cytotoxicity against HepG2 cells with an IC50 of 34.5 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AChE-IN-107 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Human hepatocellular carcinoma HepG2 cell line
Concentration: 0.005-100.0 μM
Incubation Time: 48 h
Result: Exhibited an IC50 of 34.5 μM for inhibiting HepG2 cell viability, indicating moderate cytotoxicity (1 μM < IC50 < 100 μM).
Molecular Weight

257.29

Formula

C13H15N5O
SMILES

O=C1N(C)C(C)=CN2C1=CC3=C(N(C)C)N=CN=C32
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AChE-IN-107 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE-IN-107Cholinesterase (ChE)peripheral anionic sitehepatocellular carcinoma HepG2 cellsTrp86catalytic anionic sitealzheimer's diseaseelectric eel acetylcholinesterasehuman acetylcholinesteraseTyr133Tyr337equine serum butyrylcholinesteraseInhibitorinhibitorinhibit

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