AChE-IN-107
AChE-IN-107 is a selective acetylcholinesterase (AChE) inhibitor with an IC50 of 0.22 μM and a Ki of 0.207 μM. AChE-IN-107 shows no inhibitory effect on equine serum BChE at 10 μM. AChE-IN-107 exhibits mixed-type inhibition of electric eel acetylcholinesterase, binding to both free enzyme and enzyme-substrate complex. AChE-IN-107 acts as a cytotoxin, reduces cell viability in hepatocellular carcinoma HepG2 cells.AChE-IN-107 can be used for the research of alzheimer's disease.
For research use only. We do not sell to patients.
- Formula: C13H15N5O
- Molecular Weight:257.29
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
AChE 0.22 μM (IC50) |
AChE 0.207 μM (Ki) |
AChE-IN-107 (compound 22) binds to the CAS of hAChE with favorable energy and key interactions with Trp86, Tyr133, and Tyr337[1].
AChE-IN-107 has favorable ADMET properties including predicted blood-brain barrier penetration and low liver injury risk (class I)[1].
AChE-IN-107 (0.005-100.0 μM; 48 h) exhibits moderate cytotoxicity against HepG2 cells with an IC50 of 34.5 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Human hepatocellular carcinoma HepG2 cell line
-
Concentration:0.005-100.0 μM
-
Incubation Time:48 h
-
Result:Exhibited an IC50 of 34.5 μM for inhibiting HepG2 cell viability, indicating moderate cytotoxicity (1 μM < IC50 < 100 μM).
Chemical Information
-
Molecular Weight 257.29
-
Formula C13H15N5O
-
SMILES
O=C1N(C)C(C)=CN2C1=CC3=C(N(C)C)N=CN=C32
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz