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United States

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製品番号: HY-181161

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AChE-IN-107

AChE-IN-107 is a selective acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 0.22 μM and a K_i of 0.207 μM. AChE-IN-107 shows no inhibitory effect on equine serum BChE at 10 μM. AChE-IN-107 exhibits mixed-type inhibition of electric eel acetylcholinesterase, binding to both free enzyme and enzyme-substrate complex. AChE-IN-107 acts as a cytotoxin, reduces cell viability in hepatocellular carcinoma HepG2 cells.AChE-IN-107 can be used for the research of alzheimer's disease.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₃H₁₅N₅O
分子量:257.29

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

AChE-IN-107 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

AChE

0.22 μM (IC₅₀)

AChE

0.207 μM (Ki)

Cholinesterase (ChE) アイソフォーム固有の製品をすべて表示 :

AChE
BChE

体外実験

AChE-IN-107 (compound 22) binds to the CAS of hAChE with favorable energy and key interactions with Trp86, Tyr133, and Tyr337^[1].
AChE-IN-107 has favorable ADMET properties including predicted blood-brain barrier penetration and low liver injury risk (class I)^[1].
AChE-IN-107 (0.005-100.0 μM; 48 h) exhibits moderate cytotoxicity against HepG2 cells with an IC₅₀ of 34.5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

Human hepatocellular carcinoma HepG2 cell line
Concentration:

0.005-100.0 μM
Incubation Time:

48 h
Result:

Exhibited an IC₅₀ of 34.5 μM for inhibiting HepG2 cell viability, indicating moderate cytotoxicity (1 μM < IC50 < 100 μM).

化学情報

分子量 257.29
分子式 C₁₃H₁₅N₅O
SMILES

O=C1N(C)C(C)=CN2C1=CC3=C(N(C)C)N=CN=C32
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (275 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Muzychka LV, et al. Design, synthesis and evaluation of new pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidines as tacrine-like acetylcholinesterase inhibitors. RSC Adv. 2026;16(3):2417-2427. Published 2026 Jan 12. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
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AChE-IN-107

Cholinesterase (ChE) アイソフォーム固有の製品をすべて表示