AChE-IN-116
AChE-IN-116 is a selective acetylcholinesterase (AChE) inhibitor with an electric eel AChE IC50 of 1.60 μM and Ki of 1.72 μM. AChE-IN-116 exhibits weak ability to scavenge DPPH radical. AChE-IN-116 can be used for the research of Alzheimer's disease.
For research use only. We do not sell to patients.
- Formula: C29H34N6O3
- Molecular Weight:514.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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eel AChE 1.60 μM (IC50) |
eel AChE 1.72 μM (Ki) |
equine serum BChE >100 μM (IC50) |
AChE-IN-116 (Compound 9 s) potently and selectively inhibits electric eel AChE with an IC50 of 1.60 μM, showing 29.85-fold greater selectivity for AChE over equine serum BuChE[1].
AChE-IN-116 (0.80-3.20 μM) acts as a mixed-type inhibitor of electric eel AChE with an inhibition constant (Ki) of 1.72 μM[1].
AChE-IN-116 binds simultaneously to the catalytic active site (CAS) and peripheral anionic site (PAS) of human AChE, but only binds to the CAS of human BuChE, consistent with its selective AChE inhibition[1].
AChE-IN-116 exhibits an IC50 of 419.24 μM against DPPH radical[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 514.62
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Formula C29H34N6O3
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SMILES
COC1=CC(CN2CCC(C2)NC3=NC=C(C=N3)C(NC4=CC=C(C=C4)C(N5CCCCC5)=O)=O)=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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