AChE-IN-116 

AChE-IN-116 is a selective acetylcholinesterase (AChE) inhibitor with an electric eel AChE IC₅₀ of 1.60 μM and K_i of 1.72 μM. AChE-IN-116 exhibits weak ability to scavenge DPPH radical. AChE-IN-116 can be used for the research of Alzheimer's disease^[1].

AChE-IN-116 (Compound 9 s) potently and selectively inhibits electric eel AChE with an IC₅₀ of 1.60 μM, showing 29.85-fold greater selectivity for AChE over equine serum BuChE^[1].
AChE-IN-116 (0.80-3.20 μM) acts as a mixed-type inhibitor of electric eel AChE with an inhibition constant (K_i) of 1.72 μM^[1].
AChE-IN-116 binds simultaneously to the catalytic active site (CAS) and peripheral anionic site (PAS) of human AChE, but only binds to the CAS of human BuChE, consistent with its selective AChE inhibition^[1].
AChE-IN-116 exhibits an IC₅₀ of 419.24 μM against DPPH radical^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

514.62

C₂₉H₃₄N₆O₃

COC1=CC(CN2CCC(C2)NC3=NC=C(C=N3)C(NC4=CC=C(C=C4)C(N5CCCCC5)=O)=O)=CC=C1

Room temperature in continental US; may vary elsewhere.

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• [1]. Wang YX, et al. Novel 2-aminopyrimidine carboxamide derivatives as potential anti-Alzheimer's disease agents: Design, synthesis, biological activity and computational simulation evaluation. Bioorg Med Chem Lett. 2026;137:130650.