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Results for "

BF

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (2) Androgen Receptor (3) Apoptosis (1) Aurora Kinase (2) Autophagy (2) Bacterial (1) COX (1) Histamine Receptor (1) Influenza Virus (2) Lipoxygenase (1) Microtubule/Tubulin (1) Parasite (2) PI4K (1) Reverse Transcriptase (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Endocrinology (1) Infection (2) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (3)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112830

BF-168

Amyloid-β Neurological Disease

BF-168, a candidate probe for PET, is found to specifically recognize both neuritic and diffuse plaques, with a K_i of 6.4 nM for Aβ1-42.
HY-105252A

BF 227

Amyloid-β Neurological Disease

BF 227 is a candidate for an amyloid imaging probe for PET, with a K_i of 4.3 nM for Aβ1-42 fibrils.
HY-U00426

BF738735

2 Publications Verification

PI4K Reverse Transcriptase Infection

BF738735 is a phosphatidylinositol 4-kinase III beta (PI4KIIIβ) inhibitor with an IC₅₀ of 5.7 nM.

BF-168	Amyloid-β	Neurological Disease
BF-168, a candidate probe for PET, is found to specifically recognize both neuritic and diffuse plaques, with a K_i of 6.4 nM for Aβ1-42.

BF 227	Amyloid-β	Neurological Disease
BF 227 is a candidate for an amyloid imaging probe for PET, with a K_i of 4.3 nM for Aβ1-42 fibrils.

BF738735 2 Publications Verification	PI4K Reverse Transcriptase	Infection
BF738735 is a phosphatidylinositol 4-kinase III beta (PI4KIIIβ) inhibitor with an IC₅₀ of 5.7 nM.

HY-120726

BF844	Others	Others
BF844 mitigate hearing loss associated with USH3 (usher syndrome type III) mutation CLRN1 (clarin-1) ^N48K. BF844 induces CLRN1 ^N48K transportes to the plasma membrane. BF844 shows significantly preserves hearing in vivo .

HY-106897

BF389 Biofor 389	COX Lipoxygenase	Inflammation/Immunology
BF389 (Biofor 389) is an orally active anti-inflammatory and analesis agent. BF389 is also an inhibitor of cyclooxygenase and 5-lipoxygenase, with IC₅₀s of 4 and 8 ug/mL for COX-1 and COX-2 respectively. BF389 can be used for arthritis research .

HY-12199B

Pitolisant hydrochloride 1 Publications Verification Ciproxidine; BF 2649	Histamine Receptor	Neurological Disease Endocrinology
Pitolisant hydrochloride is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (K_i=0.16 nM).

HY-P3350

LS-BF1	Bacterial	Infection
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].

HY-N3009

Secoxyloganin	Others	Cardiovascular Disease
Secoxyloganin, isolated from Lonicera japonica Thunb, inhibits the blood flow (BF) decrease. Secoxyloganin has allergy-preventive activity .

HY-157464

[Ru(phen)2(4-Me-Sal)]BF4	Others	Cancer
[Ru(phen)2(4-Me-Sal)]BF4 (compound 10), a Ru(II)-based polypyridyl complexe, displays outstanding antiproliferative activity against drug-sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cells (IC₅₀=0.52 μM and 5.56 μM, respectively) .

HY-163356

Tubulin polymerization-IN-60	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-60 (BF3) is a tubulin polymerization inhibitor with anticancer activity. Tubulin polymerization-IN-60 (BF3) belongs to the colchicine binding site inhibitors (CBSIs) and disturbs cell cycle progression leading to G2/M arrest and apoptosis .

HY-120018

VPC-13566	Androgen Receptor	Cancer
VPC-13566, a BF3-specific small molecule, is an androgen receptor (AR) inhibitor. VPC-13566 is effective in inhibiting AR transcriptional activity in vitro as well as the growth of AR-dependent PCa cell lines. VPC-13566 can be used as a chemical probe to help identify unknown AR partners.VPC-13566 can be used for the research of cancer.

HY-123308

VPC13163

Androgen Receptor Cancer

VPC13163 is a potent androgen receptor (AR) BF3 inhibitor with an IC₅₀ of 0.31 µM. VPC13163 has anticancer effects .

VPC13163	Androgen Receptor	Cancer
VPC13163 is a potent androgen receptor (AR) BF3 inhibitor with an IC₅₀ of 0.31 µM. VPC13163 has anticancer effects .

HY-141487

CLP-3094 2 Publications Verification	Androgen Receptor	Metabolic Disease Inflammation/Immunology
CLP-3094 is a potent *BF3* (binding function 3)-directed inhibitor of the androgen receptor (AR). CLP-3094 inhibits AR transcriptional activity (IC₅₀=4 μM) . CLP-3094 is a selective, potent GPR142 antagonist .

HY-12054

Hesperadin Maximum Cited Publications 6 Publications Verification	Aurora Kinase Autophagy Influenza Virus Parasite	Cancer
Hesperadin is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin inhibits Aurora B with an IC₅₀ of 250 nM. Hesperadin inhibits the growth of Trypanosoma brucei by blocking nuclear division and cytokinesis. Hesperadin also is a broad-spectrum influenza antiviral .

HY-12054A

Hesperadin hydrochloride	Aurora Kinase Autophagy Influenza Virus Parasite	Cancer
Hesperadin hydrochloride is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin hydrochloride inhibits Aurora B with an IC₅₀ of 250 nM .

Cat. No.	Product Name	Target	Research Area

HY-P3350

LS-BF1	Bacterial	Infection
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].

Secoxyloganin	Cardiovascular Disease Caprifoliaceae Iridoids Classification of Application Fields Lonicera japonica Thunb. Terpenoids Source classification Plants Disease Research Fields	Others
Secoxyloganin, isolated from Lonicera japonica Thunb, inhibits the blood flow (BF) decrease. Secoxyloganin has allergy-preventive activity .

Species:	Human (3) Mouse (1)
Tag:	His (4) Avi (2)
Source:	HEK293 (3) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P7813

	Complement Factor B/CFB Protein, Human (HEK293, His) rHuComplement Factor B, His; Complement Factor B; C3/C5 Convertase; Glycine-Rich Beta Glycoprotein; GBG; PBF2; Properdin Factor B; CFB; BF; BFD	Human	HEK293

HY-P72137

	CFB Protein, Mouse (His) 1 Publications Verification Cfb; BF; H2-BFComplement factor B; EC 3.4.21.47; C3/C5 convertase; Complement factor B Ba fragment; Complement factor B Bb fragment	Mouse	E. coli
	CFB is an important component of the alternative pathway of the complement system and is cleaved by factor D, producing two fragments: Ba and Bb. The Bb fragment is characterized as a serine protease and subsequently forms a complex with complement factor 3b, ultimately producing a C3 or C5 convertase. CFB Protein, Mouse (His) is the recombinant mouse-derived CFB protein, expressed by E. coli , with N-6*His labeled tag. The total length of CFB Protein, Mouse (His) is 739 a.a., with molecular weight of ~87 kDa.

HY-P701281

	FITC-labeled HER3 Protein, Human (HEK293, His) ERBB3; HER3; LCCS2; MDA-BF-1; MGC88033; c-erbB3; erbB3-S; p180-ErbB3; p45-sErbB3; p85-sErbB3	Human	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. FITC-labeled HER3 Protein, Human (HEK293, His) is the recombinant human-derived FITC-labeled HER3 protein, expressed by HEK293 , with C-His, C-Avi labeled tag. The total length of FITC-labeled HER3 Protein, Human (HEK293, His) is 624 a.a., with molecular weight of 72-75 kDa.

HY-P78452

	HER3 Protein, Human (HEK293, His-Avi) ErbB3; ErbB-3; HER3; HER3c-erbB-3; LCCS2; MDA-BF-1; MGC88033; p180-ErbB3; p45-sErbB3; p85-sErbB3; ERBB3	Human	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (HEK293, His-Avi) is the recombinant human-derived HER3 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of HER3 Protein, Human (HEK293, His-Avi) is 624 a.a., with molecular weight of 72-75 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P80641

DDB1 Antibody (YA785) XPE; DDBA; XAP1; XPCE; XPE-BF; UV-DDB1	WB	Human, Mouse, Rat, Monkey
DDB1 Antibody (YA785) is a non-conjugated and Mouse origined monoclonal antibody about 127 kDa, targeting to DDB1 (2D6). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat, Monkey.

HY-P80706

Histone H2B Antibody (YA737) H2BK5ac; H2B 1A; H2B; H2B histone family; H2B2f; H2Ba; H2BF; HIST2H2BF; histone H2B; histone H2B type 1; Histone H2B type 2-F	WB, IHC-P	Human, Mouse, Rat
Histone H2B Antibody (YA737) is a non-conjugated and Mouse origined monoclonal antibody about 14 kDa, targeting to Histone H2B (7E2). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P81356

PRDM1/Blimp1 Antibody (YA1101) PRDM1; BLIMP1; PR domain zinc finger protein 1; BLIMP-1; Beta-interferon gene positive regulatory domain I-binding factor; PR domain-containing protein 1; Positive regulatory domain I-binding factor 1 (PRDI-BF1; PRDI-binding factor 1)	IHC-P	Human

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BF

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