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BF844 mitigate hearing loss associated with USH3 (usher syndrome type III) mutation CLRN1 (clarin-1)N48K. BF844 induces CLRN1N48K transportes to the plasma membrane. BF844 shows significantly preserves hearing in vivo.

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BF844 Chemical Structure

BF844 Chemical Structure

CAS No. : 1404506-35-9

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BF844 Related Antibodies

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Description

BF844 mitigate hearing loss associated with USH3 (usher syndrome type III) mutation CLRN1 (clarin-1)N48K. BF844 induces CLRN1N48K transportes to the plasma membrane. BF844 shows significantly preserves hearing in vivo[1].

In Vitro

BF844 (compound 3) (0.846 µM) effectively inhibits HSP60 activity (87.07±27.70% inhibition) and moderately inhibited HSP90 (40.06±19.10% inhibition)[1].
BF844 (2.90 µM; 24 h) induces about 6% of total CLRN1N48K to be transported to the plasma membrane in C1, D1, D6 cells[1].
BF844 (2.90 µM; 24 h) effectively increases the amount of non-glycosylated CLRN1 and non-glycosylated CLRN1 is effectively transported to the plasma membrane in C1 and D1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BF844 Related Antibodies
In Vivo

BF844 shows good penetration into the retina and cochlea in vivo[1].
BF844 (10 mg/kg; i.p.) shows significantly preserves hearing in Tg;KI/KI mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Juvenile mice[1]
Dosage: 3, 10 mg/kg (3 mg/kg for P6 (post-natal day 6) mice, 10 mg/kg for P20 (post-natal day 20) mice)
Administration: I.p.
Result: Showed AUC values were determined to be 1.76 μM.h and 1.98 μM.h.
Animal Model: P30 Tg;KI/KI C57BL/6J mice[1]
Dosage: 30 mg/kg
Administration: I.p.; daily from P30 to P45
Result: Showed significantly preserves hearing with the median threshold of sound intensity in log scale was 57.5–67.5 dB SPL and about 1,000 times more sensitive hearing compared to untreated controls at P55.
Animal Model: P10 Tg;KI/KI C57BL/6J mice[1]
Dosage: 10 mg/kg
Administration: I.p.; 10 mg/kg every other day and gradually escalated the dose up to 20 mg/kg at P28. From P30 to P45, mice received 30 mg/kg daily
Result: Showd the median threshold of sound intensity in log scale was 55, 42.5 and 37.5 dB SPL lower at 8, 16 and 32 kHz at P55, respectively.
Molecular Weight

378.85

Formula

C21H19ClN4O
CAS No.
SMILES

CC(O)(C)CN1N=C(C2=CC=CC=C2)C3=C(Cl)C(C4=CC=CC=C4)=NN=C31
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References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BF8441404506-35-9BF 844BF-844OthersHEK293 cellshearing lossHSP60HSP90non-glycosylated CLRN1C57BL/6J miceInhibitorinhibitorinhibit

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