Hesperadin hydrochloride
Based on 12 publication(s) in Google Scholar
Hesperadin hydrochloride is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin hydrochloride inhibits Aurora B with an IC50 of 250 nM.
For research use only. We do not sell to patients.
- Formula: C29H33ClN4O3S
- Molecular Weight:553.12
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Hesperadin hydrochloride
More- Nat Commun. 2025 Sep 29;16(1):8598. [Abstract]
- Adv Sci (Weinh). 2025 Mar;12(11):e2414518. [Abstract]
- Adv Sci (Weinh). 2022 Oct 30;e2205091. [Abstract]
- Cell Commun Signal. 2025 Oct 2;23(1):409. [Abstract]
- Sci Signal. 2025 Feb 18;18(874):eadg4626. [Abstract]
- Antioxid Redox Signal. 2025 Jan;42(1-3):115-132. [Abstract]
- Int J Mol Sci. 2025 Aug 20;26(16):8052. [Abstract]
- Sci Rep. 2021 Jan 27;11(1):2283. [Abstract]
- Brain Res Bull. 2021 Dec:177:31-38. [Abstract]
- Behav Neurol. 2020 Feb 3:2020:2476861. [Abstract]
- Exp Cell Res. 2021 Sep 1;406(1):112741. [Abstract]
- bioRxiv. 2024 May 31.
Customer Validation & Images
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All Aurora Kinase Isoforms
MoreAll Parasite Isoforms
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Biological Activity
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Aurora B 250 nM (IC50) |
Hesperadin (10-100 nM) inhibits the Aurora kinase-1 (TbAUK1)-mediated phosphoryation of trypanosome histone H3 (TbH3) in a dose dependent manner, with an IC50 of 40 nM[1].
Hesperadin (0.01-10 μM; 24 or 48 hours) inhibits growth of bloodstream forms (BF) and procyclic forms (PF) cultures[1].
Hesperadin (100-200 nM; 24-72 hours) alters cell morphology and inhibits cell cycle progression similar to the RNAi knockdown of TbAUK1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:M110 cells
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Concentration:0.01, 0.1, 1, 10 μM
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Incubation Time:24 hours or 48 hours
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Result:Inhibiting growth of BF cultures with an IC50 of 50 nM, while the inhibition of PF growth required approximately 11-fold more Hesperadin, with an IC50 of 550 nM.
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Cell Line:M110 cells
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Concentration:100, 200 nM
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Incubation Time:24, 48, 72 hours
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Result:Had a strong effect on cell growth and mitotic progression at 100-200 nM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-week-old female nude mice injected GBM cells[2]
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Dosage:20 mg/kg/d
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Administration:I.v. injection
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Result:Increased the survival of xenograft mice models.
Chemical Information
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Molecular Weight 553.12
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Formula C29H33ClN4O3S
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SMILES
O=C1NC2=CC=C(C=C2/C1=C(NC3=CC=C(C=C3)CN4CCCCC4)\C5=CC=CC=C5)NS(CC)(=O)=O.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (12)
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Journal Impact Factor
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Most Recent
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Nat Commun
Cytoplasmic TRIM24 promotes colorectal cancer cell proliferation by activating Wnt/β-catenin signaling. [Abstract]2025 Sep 29;16(1):8598. PMID: 41022821 -
Adv Sci (Weinh)
Ischemic Area-Targeting and Self-Monitoring Nanoprobes Ameliorate Myocardial Ischemia/Reperfusion Injury by Scavenging ROS and Counteracting Cardiac Inflammation. [Abstract]2025 Mar;12(11):e2414518. PMID: 39840521 -
Adv Sci (Weinh)
N6 -Methyladenosine-Modified CBX1 Regulates Nasopharyngeal Carcinoma Progression Through Heterochromatin Formation and STAT1 Activation. [Abstract]2022 Oct 30;e2205091. PMID: 36310139 -
Cell Commun Signal
2025 Oct 2;23(1):409. PMID: 41039590 -
Sci Signal
Sustained chromosomal passenger complex activity preserves the pluripotency of human embryonic carcinoma cells. [Abstract]2025 Feb 18;18(874):eadg4626. PMID: 40136047 -
Antioxid Redox Signal
CARD11-BCL10-MALT1 complex-dependent MALT1 activation facilitates myocardial oxidative stress in doxorubicin-treated mice via enhancing k48-linked ubiquitination of Nrf2. [Abstract]2025 Jan;42(1-3):115-132. PMID: 38814831 -
Int J Mol Sci
STK26 Promotes the Stabilization of ATF6 to Facilitate the Progression of Colorectal Cancer. [Abstract]2025 Aug 20;26(16):8052. PMID: 40869379 -
Sci Rep
Depletion of Survivin suppresses docetaxel-induced apoptosis in HeLa cells by facilitating mitotic slippage. [Abstract]2021 Jan 27;11(1):2283. PMID: 33504817 -
Brain Res Bull
MST4 attenuates NLRP3 inflammasome-mediated neuroinflammation and affects the prognosis after intracerebral hemorrhage in mice. [Abstract]2021 Dec:177:31-38. PMID: 34534636 -
Behav Neurol
MST4 Kinase Inhibitor Hesperadin Attenuates Autophagy and Behavioral Disorder via the MST4/AKT Pathway in Intracerebral Hemorrhage Mice. [Abstract]2020 Feb 3:2020:2476861. PMID: 32089749
Hesperadin hydrochloride purchased from MedChemExpress. Usage Cited in: Behav Neurol. 2020 Feb 3:2020:2476861. [Abstract]
Administration of hesperadin influences endogenous expression of MST4, pAKT, AKT, and LC3 12 h following ICH. Representative western blot bands for MST4, pAKT, AKT, and LC3 expression in sham and ICH mice 12 h following ICH.
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Exp Cell Res
RNA-binding protein RNPC1 acts as an oncogene in gastric cancer by stabilizing aurora kinase B mRNA. [Abstract]2021 Sep 1;406(1):112741. PMID: 34302858 -
Purity & Documentation
References
[1]. Neal J, et, al. The cell cycle as a therapeutic target against Trypanosoma brucei: Hesperadin inhibits Aurora kinase-1 and blocks mitotic progression in bloodstream forms. Mol Microbiol. 2009 Apr; 72(2): 442-58. [Content Brief]
[2]. Wahafu A, et, al. Targeting Aurora kinase B attenuates chemoresistance in glioblastoma via a synergistic manner with temozolomide. Pathol Res Pract. 2019 Nov; 215(11): 152617. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hesperadin hydrochloride Related Classifications
HY-12054A Related Classifications
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