1. Cell Cycle/DNA Damage
    Epigenetics
    Autophagy
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  2. Aurora Kinase
    Autophagy
    Influenza Virus
    Parasite
  3. Hesperadin hydrochloride

Hesperadin hydrochloride 

Cat. No.: HY-12054A
Handling Instructions

Hesperadin hydrochloride is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin hydrochloride inhibits Aurora B with an IC50 of 250 nM.

For research use only. We do not sell to patients.

Hesperadin hydrochloride Chemical Structure

Hesperadin hydrochloride Chemical Structure

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Top Publications Citing Use of Products

Publications Citing Use of MCE Hesperadin hydrochloride

    Hesperadin hydrochloride purchased from MCE. Usage Cited in: Behav Neurol. 2020 Feb 3;2020:2476861.

    Administration of hesperadin influences endogenous expression of MST4, pAKT, AKT, and LC3 12 h following ICH. Representative western blot bands for MST4, pAKT, AKT, and LC3 expression in sham and ICH mice 12 h following ICH.

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    Description

    Hesperadin hydrochloride is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin hydrochloride inhibits Aurora B with an IC50 of 250 nM[1].

    IC50 & Target[1]

    Aurora B

    250 nM (IC50)

    In Vitro

    Hesperadin (10-100 nM) inhibits the Aurora kinase-1 (TbAUK1)-mediated phosphoryation of trypanosome histone H3 (TbH3) in a dose dependent manner, with an IC50 of 40 nM[1].
    Hesperadin (0.01-10 μM; 24 or 48 hours) inhibits growth of bloodstream forms (BF) and procyclic forms (PF) cultures[1].
    Hesperadin (100-200 nM; 24-72 hours) alters cell morphology and inhibits cell cycle progression similar to the RNAi knockdown of TbAUK1[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1]

    Cell Line: M110 cells
    Concentration: 0.01, 0.1, 1, 10 μM
    Incubation Time: 24 hours or 48 hours
    Result: Inhibiting growth of BF cultures with an IC50 of 50 nM, while the inhibition of PF growth required approximately 11-fold more Hesperadin, with an IC50 of 550 nM.

    Cell Cycle Analysis[1]

    Cell Line: M110 cells
    Concentration: 100, 200 nM
    Incubation Time: 24, 48, 72 hours
    Result: Had a strong effect on cell growth and mitotic progression at 100-200 nM.
    In Vivo

    Hesperadin (20 mg/kg/d; i.v.) prolongs the survival of xenograft mice via synergistic effect with Temozolomide (TMZ)[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 6-week-old female nude mice injected GBM cells[2]
    Dosage: 20 mg/kg/d
    Administration: I.v. injection
    Result: Increased the survival of xenograft mice models.
    Molecular Weight

    553.12

    Formula

    C₂₉H₃₃ClN₄O₃S

    SMILES

    O=C1NC2=CC=C(C=C2/C1=C(NC3=CC=C(C=C3)CN4CCCCC4)\C5=CC=CC=C5)NS(CC)(=O)=O.[H]Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
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    Keywords:

    HesperadinAurora KinaseAutophagyInfluenza VirusParasiteAuroraABbloodstreamprocyclicformsBFPFInhibitorinhibitorinhibit

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    Product Name:
    Hesperadin hydrochloride
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