1. Cell Cycle/DNA Damage Epigenetics Autophagy Anti-infection
  2. Aurora Kinase Autophagy Influenza Virus Parasite
  3. Hesperadin hydrochloride

Hesperadin hydrochloride is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin hydrochloride inhibits Aurora B with an IC50 of 250 nM.

For research use only. We do not sell to patients.

Hesperadin hydrochloride Chemical Structure

Hesperadin hydrochloride Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Hesperadin hydrochloride:

Other Forms of Hesperadin hydrochloride:

Top Publications Citing Use of Products

    Hesperadin hydrochloride purchased from MedChemExpress. Usage Cited in: Behav Neurol. 2020 Feb 3;2020:2476861.  [Abstract]

    Administration of hesperadin influences endogenous expression of MST4, pAKT, AKT, and LC3 12 h following ICH. Representative western blot bands for MST4, pAKT, AKT, and LC3 expression in sham and ICH mice 12 h following ICH.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Hesperadin hydrochloride is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin hydrochloride inhibits Aurora B with an IC50 of 250 nM[1].

    IC50 & Target[1]

    Aurora B

    250 nM (IC50)

    In Vitro

    Hesperadin (10-100 nM) inhibits the Aurora kinase-1 (TbAUK1)-mediated phosphoryation of trypanosome histone H3 (TbH3) in a dose dependent manner, with an IC50 of 40 nM[1].
    Hesperadin (0.01-10 μM; 24 or 48 hours) inhibits growth of bloodstream forms (BF) and procyclic forms (PF) cultures[1].
    Hesperadin (100-200 nM; 24-72 hours) alters cell morphology and inhibits cell cycle progression similar to the RNAi knockdown of TbAUK1[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1]

    Cell Line: M110 cells
    Concentration: 0.01, 0.1, 1, 10 μM
    Incubation Time: 24 hours or 48 hours
    Result: Inhibiting growth of BF cultures with an IC50 of 50 nM, while the inhibition of PF growth required approximately 11-fold more Hesperadin, with an IC50 of 550 nM.

    Cell Cycle Analysis[1]

    Cell Line: M110 cells
    Concentration: 100, 200 nM
    Incubation Time: 24, 48, 72 hours
    Result: Had a strong effect on cell growth and mitotic progression at 100-200 nM.
    In Vivo

    Hesperadin (20 mg/kg/d; i.v.) prolongs the survival of xenograft mice via synergistic effect with Temozolomide (TMZ)[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 6-week-old female nude mice injected GBM cells[2]
    Dosage: 20 mg/kg/d
    Administration: I.v. injection
    Result: Increased the survival of xenograft mice models.
    Molecular Weight

    553.12

    Formula

    C29H33ClN4O3S

    SMILES

    O=C1NC2=CC=C(C=C2/C1=C(NC3=CC=C(C=C3)CN4CCCCC4)\C5=CC=CC=C5)NS(CC)(=O)=O.[H]Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Purity & Documentation
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

     

    Salutation

    Applicant Name *

     

    Email Address *

    Phone Number *

     

    Organization Name *

    Department *

     

    Requested quantity *

    Country or Region *

         

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Hesperadin hydrochloride
    Cat. No.:
    HY-12054A
    Quantity:
    MCE Japan Authorized Agent: