1. Neuronal Signaling
  2. Amyloid-β

BF 227 

Cat. No.: HY-105252A
Handling Instructions

BF 227 is a candidate for an amyloid imaging probe for PET, with a Ki of 4.3 nM for Aβ1-42 fibrils.

For research use only. We do not sell to patients.

BF 227 Chemical Structure

BF 227 Chemical Structure

CAS No. : 845647-80-5

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

BF 227 is a candidate for an amyloid imaging probe for PET, with a Ki of 4.3 nM for Aβ1-42 fibrils.

IC50 & Target

Ki: 4.3 nM (Aβ1-42)[1].

In Vitro

BF-227 has a high binding affinity for Aβ1-42 fibrils. The Ki value for Aβ1-42 fibrils in competitive binding assay using [125I]BF-180 is 4.3±1.3 nM in BF-227 (Kd value of [125I]BF-180: 10.8±1.5 nM)[1]. [11C]BF-227 is a PET tracer. The AUC for BF-227 (0.994) is much higher than that for FDG (0.839), indicating that BF-227 is more sensitive as well as more specific than FDG in diagnosing AD[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9996 mL 14.9979 mL 29.9958 mL
5 mM 0.5999 mL 2.9996 mL 5.9992 mL
10 mM 0.3000 mL 1.4998 mL 2.9996 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

333.38

Formula

C₁₆H₁₆FN₃O₂S

CAS No.

845647-80-5

SMILES

CN(C)C1=NC=C(S1)/C=C/C2=NC3=CC=C(OCCF)C=C3O2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
BF 227
Cat. No.:
HY-105252A
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BF 227

Cat. No.: HY-105252A