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CCF

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By Targets:	Apoptosis (2) Bacterial (1) Endogenous Metabolite (1) Fluorescent Dye (2) PDI (2) Reference Standards (1) SARS-CoV (1) Small Interfering RNA (siRNA) (1) Virus Protease (1)
By Research Areas:	Cancer (2) Infection (3) Metabolic Disease (1) Neurological Disease (2)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100430

CCF642 1 Publications Verification	Apoptosis PDI	Cancer
CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC₅₀ of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity .

HY-132306

CCF0058981 1 Publications Verification CCF981	SARS-CoV Virus Protease	Infection
CCF0058981 (CCF981), 3-chlorophenyl analogue, is a noncovalent SARS-CoV-2 3CL ^pro (SC2) inhibitor with an IC₅₀ of 68 nM. CCF0058981 inhibits SC1 (SARS-CoV-1 3CL ^pro) with an IC₅₀ of 19 nM. CCF0058981 has antiviral efficacy and has the potential for COVID-19 research .

HY-P11106

cCF10	Bacterial	Infection
cCF10 is a peptide sex pheromone. cCF10 induces transfer of the conjugative plasmid pCF10 from plasmid-containing donor cells to plasmid-free recipient cells. cCF10 induces Opp system and enters bacterial cells to inhibit (p)ppGpp accumulation. cCF10 reduces persister cell generation via maintaining the metabolically active state of bacteria .

HY-N16576

Ethyl lecanorate	Others	Neurological Disease
Ethyl lecanorate is a main secondary metabolite of Claviceps purpurea. Ethyl lecanorate shows neurotoxic effect with an IC₅₀ of 54 µM on CCF-STTG1 cells. Ethyl lecanorate can be used for neurological disease research .

HY-RS10581

PITX1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PITX1 Human Pre-designed siRNA Set A contains three designed siRNAs for PITX1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PITX1 Human Pre-designed siRNA Set A PITX1 Human Pre-designed siRNA Set A

HY-100430R

CCF642 (Standard)	Apoptosis Reference Standards PDI	Cancer
CCF642 (Standard) is the analytical standard of CCF642 (HY-100430). This product is intended for research and analytical applications. CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC50 of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity .

HY-D3282

CCF1	Fluorescent Dye	Metabolic Disease
CCF1 is a carbon-rhodol-based turn-on fluorescent copper sensor with high selectivity for Cu ⁺ over other biologically relevant metal ions. CCF1 detects changes in labile copper pools in living cells upon copper supplementation and/or depletion. CCF1 identifies elevations in labile copper pools in Atp7a ^-/ ^- fibroblast cell models. CCF1 can be used for the research of Menkes disease .

HY-D3283

*Ctrl-CCF1*	Fluorescent Dye	Others
Ctrl-CCF1 is a control probe for CCF1. Ctrl-CCF1 can be used to distinguish copper-dependent responses from potential dye-dependent variations, such as cellular uptake, retention, subcellular accumulation, and changes in pH, redox or hydrophobic/hydrophilic environments .

HY-103338

AM1172	Others	Neurological Disease
AM1172 is metabolically stable anandamide uptake inhibitor. AM1172 inhibits [ ³H] anandamide transport in rat cortical neurons and human CCF-STTG1 astrocytoma cells with IC₅₀ values of 2.1 μM and 2.5 μM, respectively. AM1172 can significantly inhibit AEA hydrolysis and concurrently decrease AEA uptake. AM1172 can be used for the study of endocannabinoid system regulation .

HY-P10830

AT1R epitope	Endogenous Metabolite	Infection
AT1R epitope (iCF10), a heptapeptide, is a competitive *cCF10* (a peptide pheromone) inhibitor .

Cat. No.	Product Name	Type

HY-D3282

CCF1	Fluorescent Dye
CCF1 is a carbon-rhodol-based turn-on fluorescent copper sensor with high selectivity for Cu ⁺ over other biologically relevant metal ions. CCF1 detects changes in labile copper pools in living cells upon copper supplementation and/or depletion. CCF1 identifies elevations in labile copper pools in Atp7a ^-/ ^- fibroblast cell models. CCF1 can be used for the research of Menkes disease .

HY-D3283

*Ctrl-CCF1*	Fluorescent Dye
Ctrl-CCF1 is a control probe for CCF1. Ctrl-CCF1 can be used to distinguish copper-dependent responses from potential dye-dependent variations, such as cellular uptake, retention, subcellular accumulation, and changes in pH, redox or hydrophobic/hydrophilic environments .

Cat. No.	Product Name	Target	Research Area

HY-P11106

cCF10	Bacterial	Infection
cCF10 is a peptide sex pheromone. cCF10 induces transfer of the conjugative plasmid pCF10 from plasmid-containing donor cells to plasmid-free recipient cells. cCF10 induces Opp system and enters bacterial cells to inhibit (p)ppGpp accumulation. cCF10 reduces persister cell generation via maintaining the metabolically active state of bacteria .

HY-P10830

AT1R epitope	Endogenous Metabolite	Infection
AT1R epitope (iCF10), a heptapeptide, is a competitive *cCF10* (a peptide pheromone) inhibitor .

Ethyl lecanorate	Structural Classification Alkaloids Microorganisms Other Alkaloids Indole Alkaloids Source Classification	Others
Ethyl lecanorate is a main secondary metabolite of Claviceps purpurea. Ethyl lecanorate shows neurotoxic effect with an IC₅₀ of 54 µM on CCF-STTG1 cells. Ethyl lecanorate can be used for neurological disease research .

PITX1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PITX1 Human Pre-designed siRNA Set A contains three designed siRNAs for PITX1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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