1. Anti-infection
  2. SARS-CoV
    Virus Protease
  3. CCF0058981

CCF0058981 (Synonyms: CCF981)

Cat. No.: HY-132306
Handling Instructions

CCF0058981 (CCF981), 3-chlorophenyl analogue, is a noncovalent SARS-CoV-2 3CLpro (SC2) inhibitor with an IC50 of 68 nM. CCF0058981 inhibits SC1 (SARS-CoV-1 3CLpro) with an IC50 of 19 nM. CCF0058981 has antiviral efficacy and has the potential for COVID-19 research.

For research use only. We do not sell to patients.

CCF0058981 Chemical Structure

CCF0058981 Chemical Structure

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Description

CCF0058981 (CCF981), 3-chlorophenyl analogue, is a noncovalent SARS-CoV-2 3CLpro (SC2) inhibitor with an IC50 of 68 nM. CCF0058981 inhibits SC1 (SARS-CoV-1 3CLpro) with an IC50 of 19 nM. CCF0058981 has antiviral efficacy and has the potential for COVID-19 research[1].

IC50 & Target

IC50: 68 nM (SC2) and 19 nM (SC1)[1]

In Vitro

CCF0058981 (CCF981) has cytopathic effect (CPE) inhibition (EC50=497 nM) and plaque reduction (EC50=558 nM) in vitro viral replication[1].
CCF0058981 has the 50% cytotoxic concentration (CC50) in the CPE antiviral assay of >50 μM[1].
CCF0058981 has a T1/2 of 21.1 min, a CLlnt of 141 mL/min•kg in Human liver microsomes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

442.90

Formula

C₂₄H₁₉ClN₆O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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This equation is commonly abbreviated as: C1V1 = C2V2

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CCF0058981
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HY-132306
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