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Results for "

CNP

" in MedChemExpress (MCE) Product Catalog:

24

Inhibitors & Agonists

1

Fluorescent Dyes

3

Biochemical Assay Reagents

9

Peptides

1

Natural
Products

2

Antibodies

1

Click Chemistry

5

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P1237
    C-Type Natriuretic Peptide (CNP) (1-22), human
    2 Publications Verification

    		 Histamine Receptor Cardiovascular Disease Neurological Disease Metabolic Disease
    C-Type Natriuretic Peptide (CNP) (1-22), human, a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor .
    C-Type Natriuretic Peptide (CNP) (1-22), human
  • HY-P3503
    Vosoritide

    BMN 111

    		 FGFR Others
    Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research .
    Vosoritide
  • HY-153102
    G3-CNP

    		Biochemical Assay Reagents Others
    G3-CNP is an α-amylase substrate. The absorbance of G3-CNP cleavage product 2-chloro-4-nitrophenol is measured at 405 nm, which can be used to detect enzyme activity .
    G3-CNP
  • HY-119689
    Umibecestat
    1 Publications Verification

    CNP520

    		 Beta-secretase Neurological Disease
    Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively . Umibecestat can be used for the research of alzheimer's disease.
    Umibecestat
  • HY-P5127
    CNP-38

    		Angiotensin Receptor Cardiovascular Disease
    CNP-38 is a C-type natriuretic peptide .
    CNP-38
  • HY-P1237A
    C-Type Natriuretic Peptide (CNP) (1-22), human TFA
    2 Publications Verification

    		 Histamine Receptor Endothelin Receptor Cardiovascular Disease Neurological Disease Metabolic Disease
    C-Type Natriuretic Peptide (CNP) (1-22), human (TFA),a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor .
    C-Type Natriuretic Peptide (CNP) (1-22), human TFA
  • HY-112411
    PD 174265

    		EGFR ERK PDGFR FGFR Neurological Disease Inflammation/Immunology
    PD 174265 is a highly selective, reversible EGFR/ErbB2 tyrosine kinase inhibitor (IC50=0.45 nM) and cell differentiation inducer. By blocking receptor autophosphorylation and the downstream ERK signaling pathway (with an IC50 of 0.45 μM for full-length ERK), PD 174265 effectively inhibits tumor growth and exhibits antitumor activity without obvious toxicity in in vivo models. PD 174265 drives oligodendrocyte precursor cells to switch from a proliferative state to a differentiated state, significantly upregulates the expression of myelin proteins such as CNP, PLP and MBP, and induces neurite branching. PD 174265 shows no inhibitory effect on other kinases including insulin, PDGF and basic FGF receptors, and serves as a crucial tool molecule for investigating the treatment of human epidermoid carcinoma and the mechanism of myelin repair in multiple sclerosis .
    PD 174265
  • HY-137672A
    2',3'-Cyclic NADP disodium

    2',3'-cNADP+; β-Nicotinamide adenine dinucleotide-2',3'-cyclic phosphate

    		 Phosphodiesterase (PDE) Calcium Channel Neurological Disease
    2',3'-Cyclic NADP disodium (2',3'-cNADP+; β-Nicotinamide adenine dinucleotide-2',3'-cyclic phosphate) is a substrate for 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), an enzyme abundant in myelin. It has been used in a coupled enzyme assay to quantify CNP activity. 2',3'-Cyclic NADP disodium (5 μM) increases calcium overload-induced calcium release and prevents calcium-induced swelling in rat brain mitochondria.
    2',3'-Cyclic NADP disodium
  • HY-P3624
    Cenderitide

    		Guanylate Cyclase Cardiovascular Disease
    Cenderitide is a potent agonist of particulate guanylyl cyclase receptor (pGC). Cenderitide is a natriuretic peptide (NP) composed of C-type natriuretic peptide (CNP) fused to the C-terminus of Dendroaspis natriuretic peptide (DNP). Cenderitide activates both pGC-A and pGC-B, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure. Cenderitide can be used for heart failure research .
    Cenderitide
  • HY-153101
    Gal-G2-CNP

    		Biochemical Assay Reagents Others
    Gal-G2-CNP is a galactopyranosyl maltoside. Gal-G2-CNP is an amylase substrate specific to salivary amylase, which produces a yellow hydrolyzate upon decomposition. Gal-G2-CNP can serve as a matrix for the assays of novel amylases and pancreatic amylases .
    Gal-G2-CNP
  • HY-143316
    NPR-C activator 1

    		Guanylate Cyclase Neurological Disease
    NPR-C activator 1 (Compound 1) is a potent activator of natriuretic peptide receptor C (NPR-C). C-type natriuretic peptide (CNP) is involved in the regulation of vascular homeostasis. NPR-C activator 1 is identified as a potent agonist (EC50 ∼ 1 μM) with promising in vivo pharmacokinetic properties .
    NPR-C activator 1
  • HY-15911
    CNP-AFU

    2-Chloro-4-nitrophenyl α-L-fucopyranoside

    		 Biochemical Assay Reagents Others
    CNP-AFU (2-Chloro-4-nitrophenyl α-L-fucopyranoside) is a substrate for alpha-L-fucosidase(AFU).
    CNP-AFU
  • HY-P1556
    Vasonatrin Peptide (VNP)

    		PKG Cardiovascular Disease
    Vasonatrin Peptide (VNP) is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Vasonatrin peptide possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway .
    Vasonatrin Peptide (VNP)
  • HY-N12612
    CNP0296775

    		DNA Methyltransferase Dengue Virus Infection
    CNP0296775 is an inhibitor of dengue virus methyltransferase (DENV MTase) that has the potential to disrupt the viral replication process .
    CNP0296775
  • HY-W330621
    2-Chloro-4-nitrophenyl-α-D-glucopyranoside

    CNP-α-D-Glucopyaoside

    		 Fluorescent Dye Others
    2-Chloro-4-nitrophenyl-α-D-glucopyranoside (CNP-α-D-Glucopyaoside) as a chromogenic substrate for the enzymatic activity assay of the enzyme that releases CNP from conjugated carbohydrates .
    2-Chloro-4-nitrophenyl-α-D-glucopyranoside
  • HY-175340
    Kv7.2/Kv7.3 activator-3

    		Potassium Channel TSPO Neurological Disease
    Kv7.2/Kv7.3 activator-3 (GRT-X) is an orally active Kv7.2/Kv7.3 and TSPO activator. Kv7.2/Kv7.3 activator-3 activates Kv7.2/Kv7.3, Kv7.4, and Kv7.5 with EC50 values of 0.37, 2.06, and 0.75 μM, respectively, and binds to TSPO with Ki values of 0.07 μM (rat membrane) and 4.60 μM (human U-118 MG cells). Kv7.2/Kv7.3 activator-3 prevents motor neuron degeneration in mice and humans conditioned by ALS/FTD astrocytes. Kv7.2/Kv7.3 activator-3 stimulates dorsal root ganglion axonal growth through TSPO and Kv7.2/3 activation. Kv7.2/Kv7.3 activator-3 has anti-epileptic effects in epileptic seizure models. Kv7.2/Kv7.3 activator-3 reduces pain hypersensitivity in patients with diabetic neuropathy, promotes neuronal survival and regeneration after cervical neuropathy in rats, and accelerates the recovery of normal function of sensory and motor neurons .
    Kv7.2/Kv7.3 activator-3
  • HY-RS02910
    CNP Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CNP Human Pre-designed siRNA Set A contains three designed siRNAs for CNP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CNP Human Pre-designed siRNA Set A
    CNP Human Pre-designed siRNA Set A
  • HY-RS17182
    Cnp Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Cnp Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cnp gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cnp Mouse Pre-designed siRNA Set A
    Cnp Mouse Pre-designed siRNA Set A
  • HY-RS23633
    Cnp Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Cnp Rat Pre-designed siRNA Set A contains three designed siRNAs for Cnp gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cnp Rat Pre-designed siRNA Set A
    Cnp Rat Pre-designed siRNA Set A
  • HY-P1556A
    Vasonatrin Peptide (VNP) TFA

    		PKG Metabolic Disease
    Vasonatrin Peptide (VNP) TFA is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Vasonatrin peptide TFA possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide TFA protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway .
    Vasonatrin Peptide (VNP) TFA
  • HY-RS09496
    NPPC Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    NPPC Human Pre-designed siRNA Set A contains three designed siRNAs for NPPC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    NPPC Human Pre-designed siRNA Set A
    NPPC Human Pre-designed siRNA Set A
  • HY-RS20311
    Nppc Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Nppc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nppc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Nppc Mouse Pre-designed siRNA Set A
    Nppc Mouse Pre-designed siRNA Set A
  • HY-183967
    CNP7

    		HMG-CoA Reductase (HMGCR) Cancer
    CNP7 is a covalent, selective HMGCS1 inhibitor. CNP7 reduces intracellular HMG-CoA levels. CNP7 induces global protein deisoprenylation. CNP7 exhibits a cell line-specific pattern of anticancer activity. CNP7 is applicable for cancer research .
    CNP7
  • HY-P11861
    CNP analogue-1

    		Natriuretic Peptide Receptor (NPR) Drug Derivative Cardiovascular Disease
    CNP analogue-1 is a long-acting, low-isoelectric point C-type natriuretic peptide (CNP) analog. CNP analogue-1 activates human natriuretic peptide receptor 2 (hNPR2) with an EC50 of 0.18 nM. CNP analogue-1 stimulates cGMP production and is resistant to neprilysin-mediated degradation. CNP analogue-1 induces baroreceptor-mediated heart rate elevation and enhances the maximal rates of cardiac contraction and relaxation. CNP analogue-1 can be used in the research of heart failure with preserved ejection fraction .
    CNP analogue-1

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