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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
CNP
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "CNP" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-P1237
CAS No.: 127869-51-6
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
2
2 Cited Publications
Cat. No.: HY-P1237A
CAS No.: 1966153-17-2
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
1
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Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively . Umibecestat can be used for the research of alzheimer's disease.
Cat. No.: HY-P3503
CAS No.: 1480724-61-5
Synonyms: BMN 111
Cat. No.: HY-P5127
CAS No.: 2413551-27-4
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PD 174265 is a highly selective, reversible EGFR/ErbB2 tyrosine kinase inhibitor (IC50=0.45 nM) and cell differentiation inducer. By blocking receptor autophosphorylation and the downstream ERK signaling pathway (with an IC50 of 0.45 μM for full-length ERK), PD 174265 effectively inhibits tumor growth and exhibits antitumor activity without obvious toxicity in in vivo models. PD 174265 drives oligodendrocyte precursor cells to switch from a proliferative state to a differentiated state, significantly upregulates the expression of myelin proteins such as CNP, PLP and MBP, and induces neurite branching. PD 174265 shows no inhibitory effect on other kinases including insulin, PDGF and basic FGF receptors, and serves as a crucial tool molecule for investigating the treatment of human epidermoid carcinoma and the mechanism of myelin repair in multiple sclerosis .
Cat. No.: HY-137672A
CAS No.: 100929-77-9
Synonyms: 2',3'-cNADP+; β-Nicotinamide adenine dinucleotide-2',3'-cyclic phosphate
Research Areas:
2',3'-Cyclic NADP disodium (2',3'-cNADP+; β-Nicotinamide adenine dinucleotide-2',3'-cyclic phosphate) is a substrate for 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), an enzyme abundant in myelin. It has been used in a coupled enzyme assay to quantify CNP activity. 2',3'-Cyclic NADP disodium (5 μM) increases calcium overload-induced calcium release and prevents calcium-induced swelling in rat brain mitochondria.
Cat. No.: HY-153101
CAS No.: 157381-11-8
Cat. No.: HY-P3624
CAS No.: 507289-11-4
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NPR-C activator 1 (Compound 1) is a potent activator of natriuretic peptide receptor C (NPR-C). C-type natriuretic peptide (CNP) is involved in the regulation of vascular homeostasis. NPR-C activator 1 is identified as a potent agonist (EC50 ∼ 1 μM) with promising in vivo pharmacokinetic properties .
Synonyms: 2-Chloro-4-nitrophenyl α-L-fucopyranoside
Cat. No.: HY-P1556
CAS No.: 141676-35-9
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Cat. No.: HY-N12612
CAS No.: 59204-62-5
Category:
Target:
Cat. No.: HY-W330621
CAS No.: 119047-14-2
Synonyms: CNP-α-D-Glucopyaoside
Cat. No.: HY-175340
CAS No.: 1361107-81-4
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Kv7.2/Kv7.3 activator-3 (GRT-X) is an orally active Kv7.2/Kv7.3 and TSPO activator. Kv7.2/Kv7.3 activator-3 activates Kv7.2/Kv7.3, Kv7.4, and Kv7.5 with EC50 values of 0.37, 2.06, and 0.75 μM, respectively, and binds to TSPO with Ki values of 0.07 μM (rat membrane) and 4.60 μM (human U-118 MG cells). Kv7.2/Kv7.3 activator-3 prevents motor neuron degeneration in mice and humans conditioned by ALS/FTD astrocytes. Kv7.2/Kv7.3 activator-3 stimulates dorsal root ganglion axonal growth through TSPO and Kv7.2/3 activation. Kv7.2/Kv7.3 activator-3 has anti-epileptic effects in epileptic seizure models. Kv7.2/Kv7.3 activator-3 reduces pain hypersensitivity in patients with diabetic neuropathy, promotes neuronal survival and regeneration after cervical neuropathy in rats, and accelerates the recovery of normal function of sensory and motor neurons .
Cat. No.: HY-RS02910
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Research Areas:
CNP Human Pre-designed siRNA Set A contains three designed siRNAs for CNP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17182
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Cnp Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cnp gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23633
Target:
Research Areas:
Cnp Rat Pre-designed siRNA Set A contains three designed siRNAs for Cnp gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
