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Cat. No.: HY-183967

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CNP7

CNP7 is a covalent, selective HMGCS1 inhibitor. CNP7 reduces intracellular HMG-CoA levels. CNP7 induces global protein deisoprenylation. CNP7 exhibits a cell line-specific pattern of anticancer activity. CNP7 is applicable for cancer research.

For research use only. We do not sell to patients.

Formula: C₂₃H₂₂N₄O₂
Molecular Weight:386.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CNP7 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

CNP7 (2.5-20 μM; 72 h) exhibits cell line-specific antiproliferative activity across 18 cancer and non-cancer cell lines, with resistance correlated to higher baseline and CNP7-induced HMGCS1 expression in HCT116, HT29, and HepG2 cells, and sensitivity observed in RPE1, MFE296, and MOLM13 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HCT116, HT29, HepG2, MCF7, PANC05.04, BT474, PC3, DU145, DLD1, Hela, U2OS, LnCap, RPE1, MFE296, MOLM13, JURKAT, MM.1S, SNU449
Concentration:

2.5-20 μM (cell viability assay); 1 μM (HMGCS1 expression analysis)
Incubation Time:

72 h (cell viability assay); 24 h (HMGCS1 expression analysis)
Result:

Exhibited cell line-specific antiproliferative activity.
Showed high viability across all tested concentrations in resistant cell lines (HCT116, HT29, HepG2).
Caused significant dose-dependent viability reduction in sensitive cell lines (RPE1, MFE296, MOLM13).
Induced similar sensitivity curves that saturated at earlier doses in MM1.S and SNU449 cells (compared to simvastatin).
Demonstrated higher sensitivity in RPE1 and MFE296 cells than simvastatin.
Revealed higher baseline HMGCS1 expression in resistant cell lines, which was further elevated by treatment.
Showed lower baseline HMGCS1 expression and less pronounced increase upon treatment in sensitive cell lines.

Chemical Information

Molecular Weight 386.45
Formula C₂₃H₂₂N₄O₂
SMILES

N#CN1C[C@@H](C(NCC2=CC=CC(C3=CC(C(NCC#C)=O)=CC=C3)=C2)=O)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sun L, et al. Comprehensive Chemoproteomics Unveils Selective HMG-CoA Synthase 1 Inhibitors for Targeting Mevalonate Metabolism in Cancer. J Am Chem Soc. 2026;148(20):20705-20719. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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