2. Metabolic Enzyme/Protease
  3. HMG-CoA Reductase (HMGCR)
  4. CNP7

CNP7 is a covalent, selective HMGCS1 inhibitor. CNP7 reduces intracellular HMG-CoA levels. CNP7 induces global protein deisoprenylation. CNP7 exhibits a cell line-specific pattern of anticancer activity. CNP7 is applicable for cancer research.

For research use only. We do not sell to patients.

CNP7

CNP7 Chemical Structure

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CNP7 Related Antibodies

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Description

CNP7 is a covalent, selective HMGCS1 inhibitor. CNP7 reduces intracellular HMG-CoA levels. CNP7 induces global protein deisoprenylation. CNP7 exhibits a cell line-specific pattern of anticancer activity. CNP7 is applicable for cancer research[1].

In Vitro

CNP7 (2.5-20 μM; 72 h) exhibits cell line-specific antiproliferative activity across 18 cancer and non-cancer cell lines, with resistance correlated to higher baseline and CNP7-induced HMGCS1 expression in HCT116, HT29, and HepG2 cells, and sensitivity observed in RPE1, MFE296, and MOLM13 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CNP7 Related Antibodies

Cell Viability Assay[1]

Cell Line: HCT116, HT29, HepG2, MCF7, PANC05.04, BT474, PC3, DU145, DLD1, Hela, U2OS, LnCap, RPE1, MFE296, MOLM13, JURKAT, MM.1S, SNU449
Concentration: 2.5-20 μM (cell viability assay); 1 μM (HMGCS1 expression analysis)
Incubation Time: 72 h (cell viability assay); 24 h (HMGCS1 expression analysis)
Result: Exhibited cell line-specific antiproliferative activity.
Showed high viability across all tested concentrations in resistant cell lines (HCT116, HT29, HepG2).
Caused significant dose-dependent viability reduction in sensitive cell lines (RPE1, MFE296, MOLM13).
Induced similar sensitivity curves that saturated at earlier doses in MM1.S and SNU449 cells (compared to simvastatin).
Demonstrated higher sensitivity in RPE1 and MFE296 cells than simvastatin.
Revealed higher baseline HMGCS1 expression in resistant cell lines, which was further elevated by treatment.
Showed lower baseline HMGCS1 expression and less pronounced increase upon treatment in sensitive cell lines.
Molecular Weight

386.45

Formula

C23H22N4O2
SMILES

N#CN1C[C@@H](C(NCC2=CC=CC(C3=CC(C(NCC#C)=O)=CC=C3)=C2)=O)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CNP7 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CNP7CNP 7CNP-7HMG-CoA Reductase (HMGCR)HMG-CoA synthase 1RPE1HMG-CoAHMGCS1HepG2MFE296HCT116protein deprenylationHT29catalytic cysteineInhibitorinhibitorinhibit

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