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  2. Vasonatrin Peptide (VNP) (TFA)

Vasonatrin Peptide (VNP) (TFA) 

Cat. No.: HY-P1556A Purity: 98.79%
Handling Instructions

Vasonatrin Peptide (VNP) TFA is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Vasonatrin peptide TFA possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide TFA protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway.

For research use only. We do not sell to patients.

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Vasonatrin Peptide (VNP) (TFA) Chemical Structure

Vasonatrin Peptide (VNP) (TFA) Chemical Structure

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500 μg USD 200 In-stock
Estimated Time of Arrival: December 31
1 mg USD 360 In-stock
Estimated Time of Arrival: December 31
5 mg USD 990 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Vasonatrin Peptide (VNP) TFA is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Vasonatrin peptide TFA possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide TFA protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway[1][2][3].

In Vitro

Vasonatrin Peptide (VNP) markedly enhances adiponectin mRNA expression, as well as protein secretion, however, suppresses IL-6 production in mature adipocytes. In addition, VNP significantly increases the intracellular levels of cGMP. The effects of VNP are mimicked by 8-br-cGMP, whereas inhibits by HS-142-1, or KT-5823[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Vasonatrin peptide (100 μg/kg; i.v. ; 10 min before reperfusion) attenuates myocardial ischemia-reperfusion injury in diabetic rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: High-fat diet-fed streptozotocin-induced diabetic Sprague-Dawley rats[3]
Dosage: 100 μg/kg
Administration: I.v. ; 10 min before reperfusion
Result: Significantly improved the instantaneous first derivation of left ventricle pressure (±LV dP/dtmax) and LV systolic pressure and reduced LV end-diastolic pressure, apoptosis index, caspase-3 activity, plasma creatine kinase (CK), and lactate dehydrogenase (LDH) activities. Inhibited endoplasmic reticulum (ER) stress by suppressing glucose-regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP).
Molecular Weight

2979.39

Formula

C₁₂₆H₁₉₉N₃₆O₃₈S₃F₃

Sequence

Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Disulfide bridge: Cys6-Cys22)

Sequence Shortening

GLSKGCFGLKLDRIGSMSGLGCNSFRY (Disulfide bridge: Cys6-Cys22)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

References
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Keywords:

Vasonatrin Peptide (VNP) (TFA)OtherssyntheticnatriureticvasorelaxingpeptideANPCNPadipocytesdiabeticratsmyocardial ischemia-reperfusioninjuryInhibitorinhibitorinhibit

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Product Name:
Vasonatrin Peptide (VNP) (TFA)
Cat. No.:
HY-P1556A
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