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Results for "

CXC+chemokine+receptor

" in MedChemExpress (MCE) Product Catalog:

15

Inhibitors & Agonists

3

Peptides

5

Antibodies

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15319
    AMG 487
    35+ Cited Publications

    		 CXCR Inflammation/Immunology Endocrinology Cancer
    AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively .
    AMG 487
  • HY-145640
    Vimnerixin

    AZD4721; RIST4721

    		 CXCR Inflammation/Immunology
    Vimnerixin (AZD4721) is the potent and orally active antagonist of acidic CXC chemokine receptor 2 (CXCR2). Vimnerixin has the potential for the research of inflammatory disease .
    Vimnerixin
  • HY-178205
    BPRCX807

    		CXCR ERK Akt Cancer
    BPRCX 807 is a selective and potent CXCR4 (CXC chemokine receptor type 4) antagonist. BPRCX 807 inhibits CXCL12-mediated ERK and Akt phosphorylation. BPRCX 807 can significantly suppress primary tumor growth. BPRCX 807 can be used for the study of hepatocellular carcinoma .
    BPRCX807
  • HY-P4109
    vMIP-II (1-21)

    NT21MP; V1 peptide

    		 CXCR Inflammation/Immunology Cancer
    vMIP-II (1-21) (NT21MP) is an inhibitor of CXCR4. vMIP-II (1-21) interacts broadly with CC and CXC chemokine receptors. vMIP-II (1-21) inhibits CXCR4 by competing with 125I-SDF-1R for binding sites (IC50=190 nM) .
    vMIP-II (1-21)
  • HY-123819
    KRH-1636

    		CXCR Infection
    KRH-1636 is a CXC chemokine receptor (CXCR) 4 antagonist. KRH-1636 can be used in HIV-1 research .
    KRH-1636
  • HY-125567
    Antileukinate

    		CXCR Inflammation/Immunology
    Antileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury .
    Antileukinate
  • HY-15319A
    (±)-AMG 487

    		CXCR Cancer
    (±)-AMG 487 is a racemate of AMG 487. AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively .
    (±)-AMG 487
  • HY-P4109A
    vMIP-II (1-21) TFA

    NT21MP TFA; V1 peptide TFA

    		 CXCR Inflammation/Immunology Cancer
    vMIP-II (1-21) (NT21MP) TFA is an inhibitor of CXCR4. vMIP-II (1-21) TFA interacts broadly with CC and CXC chemokine receptors. vMIP-II (1-21) TFA inhibits CXCR4 by competing with 125I-SDF-1R for binding sites (IC50=190 nM) .
    vMIP-II (1-21) TFA
  • HY-139874
    CXCR2 antagonist 3

    		CXCR Inflammation/Immunology Cancer
    CXCR2 antagonist 3 (compound 11h) is a potent antagonist of CXC chemokine receptor 2 (CXCR2). CXCR2 antagonist 3 demonstrates double-digit nanomolar potencies against CXCR2 and significantly inhibited neutrophil infiltration into the air pouch. CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs and enhance the infiltration of CD3 + T lymphocytes into the Pan02 tumor tissues .
    CXCR2 antagonist 3
  • HY-111224
    GSK812397

    		HIV CXCR Infection
    GSK812397 is a CXCR4 antagonist with potential for the treatment of HIV infection. To evaluate the clinical potential of GSK812397, kilogram-scale agent candidates are needed. Here, an improved, scalable synthetic route for the CXCR4 antagonist GSK812397 is described. This new route has been scaled up in a 50-liter stationary facility to obtain 1.2 kg of agent substance in 20% overall yield and >99% chemical and enantiomeric purity in five steps. CXC chemokine receptor 4 (CXCR4) is a 7-transmembrane protein that functions in part as a host co-receptor for multiple strains of HIV-1. It is thought that targeting CXCR4 will help inhibit the replication of several late cytopathic viruses; therefore, CXCR4 antagonists are one of the most promising new classes of experimental anti-HIV agents. GSK812397 is a potent CXCR4 antagonist and is therefore a candidate for investigation for the treatment of HIV infection.
    GSK812397
  • HY-174506
    Human XCR1 mRNA

    		mRNA Cancer
    Human XCR1 mRNA encodes the human X-C motif chemokine receptor 1 (XCR1) protein, a G protein-coupled receptor that belongs to the CXC chemokine receptor family. XCR1 can transduce a signal by increasing the intracellular calcium ions level.
    Human XCR1 mRNA
  • HY-174724
    Human CXCR5 mRNA

    		mRNA Inflammation/Immunology
    Human CXCR5 mRNA encodes the human C-X-C motif chemokine receptor 5 (CXCR5) protein, a multi-pass membrane protein that belongs to the CXC chemokine receptor family. CXCR5 is involved in B-cell migration into B-cell follicles of spleen and Peyer patches.
    Human CXCR5 mRNA
  • HY-177799
    BPRCX 714

    		CXCR Cancer
    BPRCX 714 is a CXCR4 (CXC chemokine receptor type 4) receptor antagonist. BPRCX 714 can be used for the study of hepatocellular carcinoma .
    BPRCX 714
  • HY-174725
    Human CXCR4 mRNA

    		mRNA Inflammation/Immunology
    Human CXCR4 mRNA encodes the human C-X-C motif chemokine receptor 4 (CXCR4) protein, a CXC chemokine receptor specific for stromal cell-derived factor-1. CXCR4 acts with the CD4 protein to support HIV entry into cells.
    Human CXCR4 mRNA
  • HY-174723
    Human CXCR6 mRNA

    		mRNA Inflammation/Immunology
    Human CXCR6 mRNA encodes the human C-X-C motif chemokine receptor 6 (CXCR6) protein, a G protein-coupled receptor that belongs to the CXC chemokine receptor family. CXCR6 and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells.
    Human CXCR6 mRNA

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