1. GPCR/G Protein Immunology/Inflammation
  2. CXCR
  3. Antileukinate

Antileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury.

For research use only. We do not sell to patients.

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Antileukinate Chemical Structure

Antileukinate Chemical Structure

CAS No. : 138559-60-1

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Description

Antileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury[1][2][3].

In Vitro

Antileukinate inhibits the binding of human eotaxin to human eosinophils with an IC50 of 8.2 μM[2].
Antileukinate (10-100 μM; 2 hours) significantly suppresses eosinophil chemotaxis to human eotaxin[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antileukinate (52.63 mg/kg; s.c.) protectes mice against acute pancreatitis and associated lung injury[1].
Antileukinate (5mg/kg; s.c.) inhibits the interaction between murine eotaxin and murine eosinophil[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss mice (20-25g)[1]
Dosage: 52.63 mg/kg
Administration: Subcutaneous injection
Result: Reduced pancreatic edema induced by Caerulein (50 μg/kg).
Molecular Weight

1003.19

Formula

C45H66N18O7S

CAS No.
Sequence Shortening

Ac-RRWWCR-NH2

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Antileukinate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Antileukinate
Cat. No.:
HY-125567
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