Antileukinate
Antileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury.
For research use only. We do not sell to patients.
- CAS No.: 138559-60-1
- Formula: C45H66N18O7S
- Molecular Weight:1003.19
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antileukinate inhibits the binding of human eotaxin to human eosinophils with an IC50 of 8.2 μM[2].
Antileukinate (10-100 μM; 2 hours) significantly suppresses eosinophil chemotaxis to human eotaxin[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Antileukinate (5mg/kg; s.c.) inhibits the interaction between murine eotaxin and murine eosinophil[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss mice (20-25g)[1]
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Dosage:52.63 mg/kg
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Administration:Subcutaneous injection
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Result:Reduced pancreatic edema induced by Caerulein (50 μg/kg).
Chemical Information
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CAS No. 138559-60-1
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Molecular Weight 1003.19
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Formula C45H66N18O7S
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Sequence Shortening
Ac-RRWWCR-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Madhav Bhatia, et al. Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury. Regul Pept. 2007 Jan 10;138(1):40-8. [Content Brief]
[2]. Yuji Fukuno, et al. Chemokine receptor inhibitor, Antileukinate, suppressed ovalbumin-induced eosinophilic inflammation in the airway. Cytokine. 2003 Jun 7;22(5):116-25. [Content Brief]
[3]. S HayashiY, et al. Antileukinate, a hexapeptide inhibitor of CXC-chemokine receptor, suppresses bleomycin-induced acute lung injury in mice. Lung. 2002;180(6):339-48. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antileukinate Related Classifications
HY-125567 Related Classifications
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