1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. Antileukinate

Antileukinate 

Cat. No.: HY-125567
Handling Instructions

Antileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Antileukinate Chemical Structure

Antileukinate Chemical Structure

CAS No. : 138559-60-1

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Description

Antileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury[1][2][3].

In Vitro

Antileukinate inhibits the binding of human eotaxin to human eosinophils with an IC50 of 8.2 μM[2].
Antileukinate (10 μM, 100 μM) significantly suppresses eosinophil chemotaxis to human eotaxin[2].

In Vivo

Antileukinate (52.63 mg/kg; s.c.) protectes mice against acute pancreatitis and associated lung injury[1].
Antileukinate (5mg/kg; s.c.) inhibits the interaction between murine eotaxin and murine eosinophil[2].

Animal Model: Swiss mice(20-25g)[1]
Dosage: 52.63 mg/kg
Administration: Subcutaneous injection
Result: Reduced pancreatic edema induced by Caerulein (50 μg/kg).
Molecular Weight

1003.19

Formula

C₄₅H₆₆N₁₈O₇S

CAS No.

138559-60-1

Sequence Shortening

Ac-RRWWCR-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

AntileukinateCXCRCXC chemokine receptorsC-X-C motif chemokine receptorsCXCR1CXCR2neutrophilchemotaxisacuteinflammationInhibitorinhibitorinhibit

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Antileukinate
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