138559-60-1
Chemical Structure
Antileukinate
- CAS No.: 138559-60-1
- Formula:C45H66N18O7S
- Molecular Weight:1003.19
IUPAC Name: (S)-N-((6S,9R,12S,15S)-12-((1H-indol-3-yl)methyl)-1-amino-6-carbamoyl-1-imino-16-(1H-indol-3-yl)-9-(mercaptomethyl)-8,11,14-trioxo-2,7,10,13-tetraazahexadecan-15-yl)-2-((S)-2-acetamido-5-guanidinopentanamido)-5-guanidinopentanamide
InChIKey: FVRBFNYUBYTVIQ-NGTAMTFRSA-N
SMILES: CC(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CS)C(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)CC1=CNC2=C1C=CC=C2)=O)CC3=CNC4=C3C=CC=C4)=O)CCCNC(N)=N)=O)=O
Biological Activity: Antileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury[1][2][3].
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Antileukinate | Antileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury. | |||||||||||||||||||||
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References
- [1]. Madhav Bhatia, et al. Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury. Regul Pept. 2007 Jan 10;138(1):40-8. [Content Brief]
- [2]. Yuji Fukuno, et al. Chemokine receptor inhibitor, Antileukinate, suppressed ovalbumin-induced eosinophilic inflammation in the airway. Cytokine. 2003 Jun 7;22(5):116-25. [Content Brief]
- [3]. S HayashiY, et al. Antileukinate, a hexapeptide inhibitor of CXC-chemokine receptor, suppresses bleomycin-induced acute lung injury in mice. Lung. 2002;180(6):339-48. [Content Brief]
