1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. (±)-AMG 487

(±)-AMG 487 

Cat. No.: HY-15319A
Handling Instructions

(±)-AMG 487 is a racemate of AMG 487. AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.

For research use only. We do not sell to patients.

(±)-AMG 487 Chemical Structure

(±)-AMG 487 Chemical Structure

CAS No. : 947536-03-0

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Description

(±)-AMG 487 is a racemate of AMG 487. AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively[1].

Molecular Weight

603.59

Formula

C₃₂H₂₈F₃N₅O₄

CAS No.

947536-03-0

SMILES

O=C(N(C(C1=NC2=NC=CC=C2C(N1C3=CC=C(OCC)C=C3)=O)C)CC4=CC=CN=C4)CC5=CC=C(OC(F)(F)F)C=C5

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(±)-AMG 487CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsCXCR3CXCL10CXCL11chemokinereceptormetastasiscoloncancerMetastaticBreastInhibitorinhibitorinhibit

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(±)-AMG 487
Cat. No.:
HY-15319A
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