1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. AMG 487 (S-enantiomer)

AMG 487 (S-enantiomer) 

Cat. No.: HY-15319B Purity: 98.92% ee.: >99.0%
Handling Instructions

AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an antagonist of the chemokine receptor CXCR3.

For research use only. We do not sell to patients.

AMG 487 (S-enantiomer) Chemical Structure

AMG 487 (S-enantiomer) Chemical Structure

CAS No. : 473720-30-8

Size Price Stock Quantity
2 mg USD 420 In-stock
Estimated Time of Arrival: December 31
5 mg USD 840 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an antagonist of the chemokine receptor CXCR3.

IC50 & Target[1]

CXCR3

 

In Vitro

AMG 487 S-enantiomer (Compound 3.74) is the S enantiomer of AMG 487[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

603.59

Formula

C₃₂H₂₈F₃N₅O₄

CAS No.
SMILES

O=C(N([[email protected]@H](C)C1=NC2=NC=CC=C2C(N1C3=CC=C(OCC)C=C3)=O)CC4=CC=CN=C4)CC5=CC=C(OC(F)(F)F)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (248.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6568 mL 8.2838 mL 16.5675 mL
5 mM 0.3314 mL 1.6568 mL 3.3135 mL
10 mM 0.1657 mL 0.8284 mL 1.6568 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 7.5 mg/mL (12.43 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.92% ee.: >99.0%

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Keywords:

AMG 487 (S-enantiomer)CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsInhibitorinhibitorinhibit

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Product Name:
AMG 487 (S-enantiomer)
Cat. No.:
HY-15319B
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