CXCR2 antagonist 3
CXCR2 antagonist 3 (compound 11h) is a potent antagonist of CXC chemokine receptor 2 (CXCR2). CXCR2 antagonist 3 demonstrates double-digit nanomolar potencies against CXCR2 and significantly inhibited neutrophil infiltration into the air pouch. CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs and enhance the infiltration of CD3+ T lymphocytes into the Pan02 tumor tissues.
For research use only. We do not sell to patients.
- CAS No.: 2647464-92-2
- Formula: C17H15FN2O4S
- Molecular Weight:362.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BXPC-3 | IC50 |
>10 μM
Compound: 11h
|
Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
|
[PMID: 34676759] |
| MIA PaCa-2 | IC50 |
>10 μM
Compound: 11h
|
Cytotoxicity against human MIA PaCa-2 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against human MIA PaCa-2 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
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[PMID: 34676759] |
| PANC-1 | IC50 |
>10 μM
Compound: 11h
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Cytotoxicity against human PanC-1 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against human PanC-1 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
|
[PMID: 34676759] |
| PBMC | IC50 |
>10 μM
Compound: 11h
|
Cytotoxicity against human PBMC cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against human PBMC cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
|
[PMID: 34676759] |
| SW1990 | IC50 |
>10 μM
Compound: 11h
|
Cytotoxicity against human SW1990 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against human SW1990 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
|
[PMID: 34676759] |
Chemical Information
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CAS No. 2647464-92-2
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Molecular Weight 362.38
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Formula C17H15FN2O4S
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SMILES
O=S1(C2=C(O)C(NC(NC3=CC=CC(F)=C3C)=O)=CC=C2C=CC1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CXCR2 antagonist 3 Related Classifications
HY-139874 Related Classifications
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