2647464-92-2
Chemical Structure
CXCR2 antagonist 3
- CAS No.: 2647464-92-2
- Formula:C17H15FN2O4S
- Molecular Weight:362.38
IUPAC Name: 1-(3-fluoro-2-methylphenyl)-3-(8-hydroxy-1,1-dioxido-2H-thiochromen-7-yl)urea
InChIKey: HOMDQIYPTGGKMN-UHFFFAOYSA-N
SMILES: O=S1(C2=C(O)C(NC(NC3=CC=CC(F)=C3C)=O)=CC=C2C=CC1)=O
Biological Activity: CXCR2 antagonist 3 (compound 11h) is a potent antagonist of CXC chemokine receptor 2 (CXCR2). CXCR2 antagonist 3 demonstrates double-digit nanomolar potencies against CXCR2 and significantly inhibited neutrophil infiltration into the air pouch. CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs and enhance the infiltration of CD3+ T lymphocytes into the Pan02 tumor tissues[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
CXCR2 antagonist 3 | CXCR2 antagonist 3 (compound 11h) is a potent antagonist of CXC chemokine receptor 2 (CXCR2). CXCR2 antagonist 3 demonstrates double-digit nanomolar potencies against CXCR2 and significantly inhibited neutrophil infiltration into the air pouch. CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs and enhance the infiltration of CD3+ T lymphocytes into the Pan02 tumor tissues. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
