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CXCR3 Antibody

(Synonyms: CXCR3_HUMAN; Interferon-inducible protein 10 receptor; IP-10 receptor; C-X-C chemokine receptor type 3; CD 183; CD183; CD183 antigen; G protein-coupled receptor 9; G Protein Coupled Receptor 9; Chemokine (C X C motif) receptor 3; Chemokine (C X C) receptor 3; C-X-C Chemokine receptor; CXC Motif Receptor 3; Chemokine CXC Motif Receptor 3; CKRL2; CKR L2; CKR-L2; GPR9; CXC-R3; CXCR-3; IP10 receptor.)
Customer Review

Based on 1 Customer Validation

CXCR3 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to CXCR3.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for CXCR3 Antibody
  • CXCR3 Antibody Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:500-2000

Product Details

Description

CXCR3 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to CXCR3.

  • Host Rabbit
  • Clonality Polyclonal
  • Species Reactivity
    Human, Mouse, Rat Predicted Reactivity: Dog,Pig,Cow,Rabbit,GuineaPig
    Info
    Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
  • Observed Molecular Weight
    Observed band size: 40 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 40 kDa
Species Reactivity Database
Immunogen

KLH conjugated synthetic peptide derived from mouse CXCR3: 301-367/367

Sensitivity

Endogenous

Purification

affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3103263

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for CXCR3 Antibody
    Western blot analysis of extracts from 293T (lane 1) and A549 (lane 2) and M-Lymph (lane 3) using CXCR3 antibody. Proteins were transferred to a PVDF membrane and blocked with 5% nonfat powdered milk in PBST for 2 hour at room temperature. The primary antibody (1/2000) and Loading control antibody (GAPDH, 1/3000) was diluted with 5% nonfat powdered milk in PBST at 4°C overnight. Goat Anti-Rabbit IgG-HRP Secondary Antibody (1/8,000) was incubated for 45min at room temperature.

Background

  • Function

    CD183 (CXCR3) is a CXC chemokine receptor primarily expressed on activated T cells, Th1 cells, NK cells, and NKT cells. By responding to CXCL9, CXCL10, and CXCL11 signals, CD183 mediates the migration of immune cells to sites of inflammation and tumors; it serves as a key marker for studying Th1 immunity, anti-tumor immunity, immunity against infection, and autoimmune diseases.

  • Subcellular Localization

    Cell membrane; Multi-pass membrane protein; Cell membrane; Multi-pass membrane protein

  • Expression


    Tissue_specificity:Isomer 1 and isomer 2 are primarily expressed in the heart, kidneys, liver, and skeletal muscle. Isomer 1 is also expressed in the placenta. Isomer 2 is expressed in endothelial cells. It is also expressed in T cells (protein level) .

  • Isoforms & Post-Translational Modification

    CD183 (CXCR3) has 3 isomers: P49682-1: 40660 Da (predicted); P49682-2: 45523 Da (predicted); P49682-3: 28715 Da (predicted).
    Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction;N-glycosylated

  • Subunit

    Homomer. Forms heteromers with ACKR4

  • SwissProt ID

    O88410

  • Gene ID
    2833 [NCBI]
  • Synonyms

    CXCR3_HUMAN; Interferon-inducible protein 10 receptor; IP-10 receptor; C-X-C chemokine receptor type 3; CD 183; CD183; CD183 antigen; G protein-coupled receptor 9; G Protein Coupled Receptor 9; Chemokine (C X C motif) receptor 3; Chemokine (C X C) receptor 3; C-X-C Chemokine receptor; CXC Motif Receptor 3; Chemokine CXC Motif Receptor 3; CKRL2; CKR L2; CKR-L2; GPR9; CXC-R3; CXCR-3; IP10 receptor.

[1]. Huo R, et al. CXCR3 inhibitors for therapeutic interventions: current status and perspectives. Front Pharmacol. 2025 Jul 25;16:1556196. [Content Brief]

[2]. Boyé K, et al. Ligand activation induces different conformational changes in CXCR3 receptor isoforms as evidenced by plasmon waveguide resonance (PWR). Sci Rep. 2017 Sep 6;7(1):10703. [Content Brief]

[3]. Caccuri F, et al. The Synthetic Dipeptide Pidotimod Shows a Chemokine-Like Activity through CXC Chemokine Receptor 3 (CXCR3). Int J Mol Sci. 2019 Oct 24;20(21):5287. [Content Brief]

[4]. Eiger DS, et al. Location bias contributes to functionally selective responses of biased CXCR3 agonists. Nat Commun. 2022 Oct 4;13(1):5846. [Content Brief]

[5]. Wang X, et al. Effects of CXCL4/CXCR3 on the lipopolysaccharide-induced injury in human umbilical vein endothelial cells. J Cell Physiol. 2019 Dec;234(12):22378-22385. [Content Brief]

[6]. Torraca V, et al. The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection. Dis Model Mech. 2015 Mar;8(3):253-69. [Content Brief]

[7]. Wu Q, et al. Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion. Mol Cancer. 2012 Jan 11;11:3. [Content Brief]

[8]. Sheng W, et al. Astrocyte-derived CXCL10 exacerbates endothelial cells pyroptosis and blood-brain barrier disruption via CXCR3/cGAS/AIM2 pathway after intracerebral hemorrhage. Cell Death Discov. 2025 Aug 8;11(1):373. [Content Brief]

[9]. Lee J, et al. CXCR3-CXCL11 Signaling Restricts Angiogenesis and Promotes Pericyte Recruitment. Arterioscler Thromb Vasc Biol. 2024 Dec;44(12):2577-2595. [Content Brief]

[10]. Huang YV, et al. Novel Therapeutic Approach Targeting CXCR3 to Treat Immunotherapy Myocarditis. Circ Res. 2025 Feb 28;136(5):473-490. [Content Brief]

[11]. Bodnar RJ, et al. Differential regulation of pericyte function by the CXC receptor 3. Wound Repair Regen. 2015 Nov-Dec;23(6):785-96. [Content Brief]

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CXCR3 Antibody Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedchemExpress Validation
     Western blot analysis of extracts from 293T (lane 1) and A549 (lane 2) and M-Lymph (lane 3) using CXCR3 antibody. Proteins were transferred to a PVDF membrane and blocked with 5% nonfat powdered milk in PBST for 2 hour at room temperature. The primary antibody (1/2000) and Loading control antibody (GAPDH, 1/3000) was diluted with 5% nonfat powdered milk in PBST at 4°C overnight. Goat Anti-Rabbit IgG-HRP Secondary Antibody (1/8,000) was incubated for 45min at room temperature.

  • CXCR3 Antibody Product Image
    1/16
  • Experimental Validation Results for CXCR3 Antibody
  • CXCR3 Antibody Product Image
  • Experimental Validation Results for CXCR3 Antibody
    1/1
    MedchemExpress Validation
     Western blot analysis of extracts from 293T (lane 1) and A549 (lane 2) and M-Lymph (lane 3) using CXCR3 antibody. Proteins were transferred to a PVDF membrane and blocked with 5% nonfat powdered milk in PBST for 2 hour at room temperature. The primary antibody (1/2000) and Loading control antibody (GAPDH, 1/3000) was diluted with 5% nonfat powdered milk in PBST at 4°C overnight. Goat Anti-Rabbit IgG-HRP Secondary Antibody (1/8,000) was incubated for 45min at room temperature.
  • Experimental Validation Results for CXCR3 Antibody
  • CXCR3 Antibody Product Image
    MedchemExpress Validation

    Western blot analysis of extracts from 293T (lane 1) and A549 (lane 2) and M-Lymph (lane 3) using CXCR3 antibody. Proteins were transferred to a PVDF membrane and blocked with 5% nonfat powdered milk in PBST for 2 hour at room temperature. The primary antibody (1/2000) and Loading control antibody (GAPDH, 1/3000) was diluted with 5% nonfat powdered milk in PBST at 4°C overnight. Goat Anti-Rabbit IgG-HRP Secondary Antibody (1/8,000) was incubated for 45min at room temperature.

  • CXCR3 Antibody Product Image WB