Vimnerixin
Based on 1 Customer Validation
Vimnerixin (AZD4721) is the potent and orally active antagonist of acidic CXC chemokine receptor 2 (CXCR2). Vimnerixin has the potential for the research of inflammatory disease.
For research use only. We do not sell to patients.
- Purity: 99.16%
- CAS No.: 1418112-77-2
- Formula: C19H25FN4O5S2
- Molecular Weight:472.55
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
CXCR2[1]
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| In Vivo PK | Rat | Dog |
| Predicted hepatic metabolic CL (ml/min per kilogram) | 1.7 | 0.80 |
| Observed CL (ml/min per kilogram) | 2.4 | 0.50 |
| CLrenal (mL/min per kilogram) | <0.01 | <0.01 |
| CLbiliary (mL/min per kilogram) | <0.01 | 0.04 |
| In vivo/in vitro unbound CLintc | 1.4 | 0.6 |
| VSS (l/kg) | 0.19 | 0.15 |
| T1/2 (h) (PO) | 1.3 | 3.7 |
| (2.7) | (8.4) | |
| F (%) | 45 | 82 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1418112-77-2
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Appearance Solid
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Molecular Weight 472.55
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Formula C19H25FN4O5S2
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Color White to off-white
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SMILES
O=S(NC1=NC(SCC2=CC=C(C=C2)F)=NC(O[C@H](C)[C@@H](O)CO)=C1)(N3CC(C3)C)=O
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Synonyms
AZD4721; RIST4721
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (211.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.1162 mL | 10.5809 mL | 21.1618 mL | 52.9045 mL |
| 5 mM | 0.4232 mL | 2.1162 mL | 4.2324 mL | 10.5809 mL | |
| 10 mM | 0.2116 mL | 1.0581 mL | 2.1162 mL | 5.2904 mL | |
| 15 mM | 0.1411 mL | 0.7054 mL | 1.4108 mL | 3.5270 mL | |
| 20 mM | 0.1058 mL | 0.5290 mL | 1.0581 mL | 2.6452 mL | |
| 25 mM | 0.0846 mL | 0.4232 mL | 0.8465 mL | 2.1162 mL | |
| 30 mM | 0.0705 mL | 0.3527 mL | 0.7054 mL | 1.7635 mL | |
| 40 mM | 0.0529 mL | 0.2645 mL | 0.5290 mL | 1.3226 mL | |
| 50 mM | 0.0423 mL | 0.2116 mL | 0.4232 mL | 1.0581 mL | |
| 60 mM | 0.0353 mL | 0.1763 mL | 0.3527 mL | 0.8817 mL | |
| 80 mM | 0.0265 mL | 0.1323 mL | 0.2645 mL | 0.6613 mL | |
| 100 mM | 0.0212 mL | 0.1058 mL | 0.2116 mL | 0.5290 mL |
Vimnerixin Related Classifications
HY-145640 Related Classifications
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