FLI

By Targets:	Apoptosis (1) BCL6 (1) DNA/RNA Synthesis (5) iGluR (1) Isotope-Labeled Compounds (1) mRNA (1) Notch (1) Small Interfering RNA (siRNA) (4)
By Research Areas:	Cancer (8) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Transcription Factors (1) mRNA (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15860

FLI-06 Maximum Cited Publications 10 Publications Verification	Notch	Cancer
FLI-06 is an inhibitor of Notch signaling with an EC₅₀ of 2.3 μM.

HY-122903

TK216 5+ Cited Publications	DNA/RNA Synthesis	Cancer
TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor . TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity .

HY-14507

YK-4-279 5+ Cited Publications	DNA/RNA Synthesis Apoptosis	Cancer
YK-4-279 blocks RNA Helicase A (RHA) binding with EWS-FLI1 (oncogenic protein). YK-4-279 induces apoptosis and shows anti-proliferation activities towards various cancer cells. YK-4-279 has a chiral center and it can be separated into two enantiomers. YK-4-279 can be used for the research of cancer .

HY-173364

EB-TCIP BAK-04-212	BCL6	Cancer
EB-TCIP (BAK-04-212) is a proof-of-concept tool specifically designed for Ewing sarcoma research, serving as an *EWSR1::FLI1* binder tagged with BCL6 and FKBP12 ^F36V. EB-TCIP forms a ternary complex with the tagged fusion protein, specifically recruits EWSR1::FLI1 to BCL6-bound DNA loci, and induces rapid chromatin remodeling and relocalization. By mediating relocalization, EB-TCIP remodels the transcriptional machinery and activates the expression of BCL6 target genes that are originally repressed. EB-TCIP is used in studies related to novel epigenetic therapies for Ewing sarcoma .

HY-122903S

TK216-d4	Isotope-Labeled Compounds DNA/RNA Synthesis	Cancer
TK216-d₄ is the deuterium labeled TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor . TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity .

HY-RS04977

FLI1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FLI1 Human Pre-designed siRNA Set A contains three designed siRNAs for FLI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FLI1 Human Pre-designed siRNA Set A FLI1 Human Pre-designed siRNA Set A

HY-163325A

Fli-1-IN-1	DNA/RNA Synthesis	Cancer
Fli-1-IN-1 (compound 21) is a *FLI1* targeting agent that directly binds to and inhibits the *EWS-FLI1* protein interaction. EWS-FLI1 can bind to RNA helicase A, and Fli-1-IN-1 inhibits EWS-FLI1 and has potential anticancer activity .

HY-163325

Fli-1-IN-1 fumarate	DNA/RNA Synthesis	Cancer
Fli-1-IN-1 (compound 21) fumarate is a *FLI1* targeting agent that directly binds to and inhibits the *EWS-FLI1* protein interaction. EWS-FLI1 can bind to RNA helicase A, and Fli-1-IN-1 fumarate inhibits EWS-FLI1 and has potential anticancer activity .

HY-114753

Neboglamine CR-2249; XY-2401	iGluR	Neurological Disease
Neboglamine (CR-2249; XY-2401) is a modulator for N-methyl-D-aspartate (NMDA) receptor. Neboglamine increases the levels of fos-like immunoreactivity (FLI)-positive cells in the prefrontal cortex, nucleus accumbens, and lateral septal nucleus in rat models, .restores NMDA (HY-17551) -mediated neurotransmitter release, and inhibits phencyclidine-induced hyperlocomotion .

HY-RS18357

Fli1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fli1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fli1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fli1 Mouse Pre-designed siRNA Set A Fli1 Mouse Pre-designed siRNA Set A

HY-RS04978

FLII Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FLII Human Pre-designed siRNA Set A contains three designed siRNAs for FLII gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FLII Human Pre-designed siRNA Set A FLII Human Pre-designed siRNA Set A

HY-174685

*Human FLI1 mRNA*	mRNA	Cancer
Human FLI1 mRNA encodes a transcription factor containing an ETS DNA-binding domain. FLI1 is a sequence-specific transcriptional activator that can recognize the DNA sequence 5''-C[CA]GGAAGT-3''.

HY-RS24836

Fli1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fli1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fli1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fli1 Rat Pre-designed siRNA Set A Fli1 Rat Pre-designed siRNA Set A

Species:	Virus (1) Human (2)
Tag:	His (2) Strep (1) Tag Free (1)
Source:	Sf9 insect cells (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703126

	FLI1 Protein, Human Friend leukemia integration 1 transcription factor; Proto-oncogene FLI-1; Transcription factor ERGB; FLI1; Homo sapiens; Human; Activator; DNA-binding	Human	E. coli
	FLI1 Protein, Human is the recombinant human-derived FLI1, expressed by E. coli , with tag Free labeled tag.

HY-P703127

	FLI1 Protein, Human (His, Strep) Friend leukemia integration 1 transcription factor; Proto-oncogene FLI-1; Transcription factor ERGB; FLI1; Homo sapiens; Human; Activator; DNA-binding	Human	E. coli
	FLI1 Protein, Human (His, Strep) is the recombinant human-derived FLI1, expressed by E. coli , with Strep, His labeled tag.

HY-P76965

	Nucleocapsid/NP Protein, HTNV (sf9, His) 1 Publications Verification Hantaan virus HTNV (strain 84FLI) Nucleocapsid / NP Protein (His)	Virus	Sf9 insect cells
	Nucleocapsid/NP belongs to the hantavirus nucleocapsid protein family. Nucleocapsid/NP Protein, HTNV (sf9, His) is the recombinant Virus-derived Nucleocapsid/NP protein, expressed by Sf9 insect cells , with C-His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-122903S

TK216-d4
TK216-d₄ is the deuterium labeled TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor . TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity .

Host:	Mouse (3) Rabbit (2)
Reactivity:	Human (5) Mouse (1) Rat (2)
Application:	IHC-P (5) ICC/IF (1) WB (3) FC (2) ELISA (3)
Isotype:	IgG (2) IgG1 (1) IgG2b (2)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (2) Monoclonal Antibody (1) Recombinant (1)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83092

	FLI1 Antibody (YA2837) FLI1; Friend leukemia integration 1 transcription factor; Proto-oncogene FLI-1; Transcription factor ERGB	WB, IHC-P	Human, Rat
	FLI1 Antibody (YA2837) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FLI1.

HY-P83092A

	FLI1 Antibody (YA2837)(PBS only) FLI1; Friend leukemia integration 1 transcription factor; Proto-oncogene FLI-1; Transcription factor ERGB	WB, IHC-P	Human, Rat
	FLI1 Antibody (YA2837) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FLI1.

HY-P85955

	FLI1 Antibody (YA5647)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse
	FLI1 Antibody (YA5647) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FLI1.

HY-P84459

	FLI1 Antibody (YA4156) EWSR2; SIC-1; BDPLT21	IHC-P, FC, ELISA	Human
	FLI1 Antibody (YA4156) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to FLI1.

HY-P84459A

	FLI1 Antibody (YA4156)(PBS only) EWSR2; SIC-1; BDPLT21	IHC-P, FC, ELISA	Human
	FLI1 Antibody (YA4156) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to FLI1.

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Cat. No.	Product Name		Classification

HY-RS04977

FLI1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
FLI1 Human Pre-designed siRNA Set A contains three designed siRNAs for FLI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18357

Fli1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Fli1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fli1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS04978

FLII Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
FLII Human Pre-designed siRNA Set A contains three designed siRNAs for FLII gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-174685

*Human FLI1 mRNA*		mRNA Transcription Factors
Human FLI1 mRNA encodes a transcription factor containing an ETS DNA-binding domain. FLI1 is a sequence-specific transcriptional activator that can recognize the DNA sequence 5''-C[CA]GGAAGT-3''.

HY-RS24836

Fli1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Fli1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fli1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Inhibitors & Agonists

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides