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Results for "

FPR1

" in MedChemExpress (MCE) Product Catalog:

23

Inhibitors & Agonists

12

Peptides

1

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N8152
    Randialic acid B

    		Reactive Oxygen Species Inflammation/Immunology
    Randialic acid B, a triterpenoid compound, is a formyl peptide receptor 1 (FPR1) antagonist. Randialic acid B blocks FPR1 in human neutrophils and attenuates psoriasis-like inflammation in vivo [1].
    Randialic acid B
  • HY-128113
    AG-09/1

    		Formyl Peptide Receptor (FPR) Inflammation/Immunology
    AG-09/1 is a specific formyl peptide receptor 1 (FPR1) agonist. N-formyl peptide receptors (FPR) are important in host defense [1].
    AG-09/<em>1</em>
  • HY-156293
    FPR1 antagonist 1

    		Formyl Peptide Receptor (FPR) Apoptosis Cancer
    FPR1 antagonist 1 (compound 24a) is a formyl peptide receptor 1 (FPR1) antagonist with an IC50 of 25 nM. FPR1 antagonist 1 inhibits cell growth through a combined effect on cell proliferation and apoptosis and reduces cell migration, while inducing an increase in angiogenesis [1].
    <em>FPR1</em> antagonist <em>1</em>
  • HY-156294
    FPR1 antagonist 2

    		Formyl Peptide Receptor (FPR) Apoptosis Cancer
    FPR1 antagonist 2 (compound 25b) is a formyl peptide receptor 1 (FPR1) antagonist with an IC50 of 70 nM. FPR1 antagonist 2 inhibits cell growth through a combined effect on cell proliferation and apoptosis and reduces cell migration, while inducing an increase in angiogenesis [1].
    <em>FPR1</em> antagonist 2
  • HY-RS05085
    FPR1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others
    FPR1 Human Pre-designed siRNA Set A contains three designed siRNAs for FPR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    FPR1 Human Pre-designed siRNA Set A
    FPR1 Human Pre-designed siRNA Set A
  • HY-101283
    HCH6-1
    3 Publications Verification
    HCH6-1 is a potent and competitive dipeptide antagonist of Formyl peptide receptor 1 (FPR1). HCH6-1 inhibits chemotaxis, superoxide anion generation, and elastase release in human neutrophils specifically activated by fMLF (an FPR1 agonist). HCH6-1 has protective effects against acute lung injury (ALI) in vivo and can be used for the research of FPR1-involved inflammatory lung diseases [1].
    HCH6-<em>1</em>
  • HY-P1744
    N-Formyl-Met-Leu-Phe-Lys

    fMLFK

    		 Formyl Peptide Receptor (FPR) Inflammation/Immunology
    N-Formyl-Met-Leu-Phe-Lys (fMLFK) is a peptide, acts as a potent and selective agonist of FPR1, with EC50s of 3.5 nM, 6.7 μM and 0.88 μM for FPR1, FPR2 and FPR2-D281 7.32G, respectively [1].
    N-Formyl-Met-Leu-Phe-Lys
  • HY-155497
    ADS051

    BT051

    		 Formyl Peptide Receptor (FPR) Cancer
    ADS051 (BT051) is a selective, first-in-class, and orally active neutrophil activity modulator and a MRP2/FPR1 inhibitor. ADS051 (BT051) has the potential for neutrophil‐mediated disorders related diseases research [1].
    ADS051
  • HY-116216
    PD 168368

    		Bombesin Receptor Cancer
    PD 168368 is a potent, competitive, and selective neuromedin B receptor (NMB-R) antagonist with the Ki of 15–45 nM [1]. PD 168368 is neuromedin B receptor (NMBR; IC50=96 nM) / gastrin-releasing peptide receptor (GRPR IC50=3500 nM) antagonist . PD 168368 also is a mixed FPR1/FPR2/FPR3 agonist with EC50s of 0.57, 0.24, and 2.7 nM, respectively .
    PD 168368
  • HY-19574
    FPR Agonist 43
    2 Publications Verification
    FPR Agonist 43 (compound 43) is a dual formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2)/ALX agonist [1] .
    <em>FPR</em> Agonist 43
  • HY-P1795
    N-Boc-Phe-Leu-Phe-Leu-Phe
    1 Publications Verification

    Boc-FLFLF

    		 Formyl Peptide Receptor (FPR) Neurological Disease
    N-Boc-Phe-Leu-Phe-Leu-Phe (Boc-FLFLF) is a formyl peptide receptor 1 (FPR1) antagonist, which increases pain effects and inhibits antinociceptive activity of annexin [1] .
    N-Boc-Phe-Leu-Phe-Leu-Phe
  • HY-P1120
    WKYMVM

    		Formyl Peptide Receptor (FPR) Inflammation/Immunology
    WKYMVM is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase [1] .
    WKYMVM
  • HY-P1120A
    WKYMVM TFA

    		Formyl Peptide Receptor (FPR) Inflammation/Immunology
    WKYMVM (TFA) is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase [1] .
    WKYMVM TFA
  • HY-P1121A
    WKYMVM-NH2 TFA

    		Formyl Peptide Receptor (FPR) Inflammation/Immunology
    WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase [1] .
    WKYMVM-NH2 TFA
  • HY-P1122
    Cyclosporin H
    1 Publications Verification

    		 Formyl Peptide Receptor (FPR) Infection Inflammation/Immunology
    Cyclosporin H is a selective and potent inhibitor of FPR-1 (formyl peptide receptor 1). Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin (HY-10219) or Prostaglandin E2 (HY-101952). Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.
    Cyclosporin H
  • HY-144604
    FPR2 agonist 2

    		Others Infection Neurological Disease
    FPR2 agonist 2 is a potent and permeates the blood−brain barrier FPR2 agonist with an EC50 of 0.13 µM, 1.1 µM for FPR2 and FPR1, respectively. FPR2 agonist 2 inhibits the production of pro-inflammatory cytokines, counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity [1].
    <em>FPR</em>2 agonist 2
  • HY-P1116
    PBP10

    		Bacterial Infection Inflammation/Immunology
    PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1 [1]. PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects .
    PBP10
  • HY-P1116A
    PBP10 TFA
    1 Publications Verification

    		 Bacterial Infection Inflammation/Immunology
    PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1 [1]. PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects .
    PBP10 TFA
  • HY-103286
    PD176252

    		Bombesin Receptor Cancer
    PD176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC50s of 0.31 and 0.66 μM in HL-60 cells.
    PD176252
  • HY-P1117
    MMK1

    		Formyl Peptide Receptor (FPR) Calcium Channel Neurological Disease Inflammation/Immunology
    MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK1 potently activates phagocytic leukocytes and enhances Pertussis Toxin (HY-112779)-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity [1] .
    MMK<em>1</em>
  • HY-P1117A
    MMK1 TFA

    		Formyl Peptide Receptor (FPR) Calcium Channel Neurological Disease Inflammation/Immunology
    MMK1 TFA is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 TFA is a potent chemotactic and calcium-mobilizing agonist. MMK1 TFA potently activates phagocytic leukocytes and enhances Pertussis Toxin (HY-112779)-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 TFA exerts anxiolytic-like activity [1] .
    MMK<em>1</em> TFA
  • HY-P1118
    Ac9-25

    		Formyl Peptide Receptor (FPR) Inflammation/Immunology
    Ac9-25, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR .
    Ac9-25
  • HY-P1118A
    Ac9-25 TFA

    		Formyl Peptide Receptor (FPR) Inflammation/Immunology
    Ac9-25 TFA, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR .
    Ac9-25 TFA

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