2. GPCR/G Protein
  3. Formyl Peptide Receptor (FPR)
  4. Cyclosporin H

Cyclosporin H is a selective and potent inhibitor of FPR-1 (formyl peptide receptor 1). Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin (HY-10219) or Prostaglandin E2 (HY-101952). Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CAS No. : 83602-39-5

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Based on 3 publication(s) in Google Scholar

Cyclosporin H Related Antibodies

Top Publications Citing Use of Products
Histological Imaging/Staining
Bio/Physico-chemical Assay
ELISA
WB

    Cyclosporin H purchased from MedChemExpress. Usage Cited in: Res Rep Urol. 2026 Mar 7:18:578231.  [Abstract]

    Cyclosporin H (Cyclosporin) (5 mg/kg; i.p.; single dose). Representative images of HE-stained kidney tissue (red arrows indicate normal glomeruli, green arrows indicate normal renal tubules, blue arrows indicate atrophic glomeruli, purple arrows also indicate vacuolar degeneration of glomeruli, yellow arrows indicate interstitial hemorrhage), bar=100 μm.

    Cyclosporin H purchased from MedChemExpress. Usage Cited in: Res Rep Urol. 2026 Mar 7:18:578231.  [Abstract]

    Levels of blood urea nitrogen and creatinine in serum. The results showed that serum BUN and creatinine levels of were significantly elevated in the SA-AKI group compared with control, whereas in the Cyclosporin H (5 mg/kg; i.p.; single dose) intervention group they were significantly lower than in the SA-AKI group.

    Cyclosporin H purchased from MedChemExpress. Usage Cited in: Res Rep Urol. 2026 Mar 7:18:578231.  [Abstract]

    Levels of TNF-α and IL-1β in serum and kidney tissue. ELISA showed that TNF-α and IL-1β levels in serum were markedly higher in SA-AKI group than controls and were reduced by Cyclosporin H (5 mg/kg; i.p.; single dose) treatment versus SA-AKI group.

    Cyclosporin H purchased from MedChemExpress. Usage Cited in: Res Rep Urol. 2026 Mar 7:18:578231.  [Abstract]

    Cyclosporin H (5 mg/kg; i.p.; single dose). Representative images of TUNEL-stained kidney tissue (green indicates apoptotic renal epithelial cells, DAPI stains cell nuclei, Merge shows the combination of TUNEL and DAPI staining), bar=100 μm.

    Cyclosporin H purchased from MedChemExpress. Usage Cited in: Res Rep Urol. 2026 Mar 7:18:578231.  [Abstract]

    Western blot analysis of ASC, Caspase-1, NLRP3, and IL-1β protein expression changes in kidney tissues from control, SA-AKI, and Cyclosporin H (5 mg/kg; i.p.; single dose) intervention groups.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Cyclosporin H is a selective and potent inhibitor of FPR-1 (formyl peptide receptor 1). Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin (HY-10219) or Prostaglandin E2 (HY-101952). Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.

    In Vitro

    The cyclic undecapeptide, cyclosporin H, is a potent inhibitor of formyl-Met-Leu-Phe (FMLP)-induced superoxide anion (O2-) formation in human neutrophils. Cyclosporin H inhibits FMLP binding in HL-60 membranes with a Ki of 0.1 μM. Cyclosporin H inhibits activation by FMLP of high affinity GTPase (the enzymatic activity of alpha-subunits of heterotrimeric regulatory guanine nucleotide-binding proteins) in HL-60 membranes with a Ki of 0.79 μM. Cyclosporin H inhibits the stimulatory effects of FMLP on cytosolic Ca2+ concentration ([Ca2+]i), O2- formation, and beta-glucuronidase release with Ki values of 0.08, 0.24, and 0.45 μM, respectively[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Cyclosporin H Related Antibodies
    In Vivo

    Cyclosporin H (5 mg/kg; i.p.; before LPS or HCl challenge) attenuats lung injury induced by LPS or HCl (a lung injurymodel)[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    1202.61

    Formula

    C62H111N11O12
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    Cyclo[{Abu}-{Sar}-{N(Me)Leu}-Val-{N(Me)Leu}-Ala-{d-Ala}-{N(Me)Leu}-{N(Me)Leu}-{d-N(Me)Val}-{N(Me)Bmt(E)}]
    Sequence Shortening

    Cyclo[{Abu}-{Sar}-{N(Me)Leu}-V-{N(Me)Leu}-A-{d-Ala}-{N(Me)Leu}-{N(Me)Leu}-{d-N(Me)Val}-{N(Me)Bmt(E)}]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (83.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.8315 mL 4.1576 mL 8.3152 mL
    5 mM 0.1663 mL 0.8315 mL 1.6630 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: 3 mg/mL (2.49 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 3 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: 3 mg/mL (2.49 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 3 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  0.5% CMC-Na/saline water

      Solubility: 1.25 mg/mL (1.04 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.87%

    SDS (480 KB)

    COA (263 KB) RP-HPLC (250 KB) MS (175 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 0.8315 mL 4.1576 mL 8.3152 mL 20.7881 mL
    5 mM 0.1663 mL 0.8315 mL 1.6630 mL 4.1576 mL
    10 mM 0.0832 mL 0.4158 mL 0.8315 mL 2.0788 mL
    15 mM 0.0554 mL 0.2772 mL 0.5543 mL 1.3859 mL
    20 mM 0.0416 mL 0.2079 mL 0.4158 mL 1.0394 mL
    25 mM 0.0333 mL 0.1663 mL 0.3326 mL 0.8315 mL
    30 mM 0.0277 mL 0.1386 mL 0.2772 mL 0.6929 mL
    40 mM 0.0208 mL 0.1039 mL 0.2079 mL 0.5197 mL
    50 mM 0.0166 mL 0.0832 mL 0.1663 mL 0.4158 mL
    60 mM 0.0139 mL 0.0693 mL 0.1386 mL 0.3465 mL
    80 mM 0.0104 mL 0.0520 mL 0.1039 mL 0.2599 mL
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    Cyclosporin H Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Cyclosporin H83602-39-5Formyl Peptide Receptor (FPR)viraltransductionlentiviralInhibitorinhibitorinhibit

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