FPR1 antagonist 1
Based on 1 Customer Validation
FPR1 antagonist 1 (compound 24a) is a formyl peptide receptor 1 (FPR1) antagonist with an IC50 of 25 nM. FPR1 antagonist 1 inhibits cell growth through a combined effect on cell proliferation and apoptosis and reduces cell migration, while inducing an increase in angiogenesis.
For research use only. We do not sell to patients.
- Purity: 95.00%
- CAS No.: 3053980-28-9
- Formula: C25H28O5
- Molecular Weight:408.49
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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GPCR/G Protein Compound Library
HY-L006
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Anti-Cancer Compound Library
HY-L025
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Cell Death Library
HY-L162
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
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Lactylation Compound Library
HY-L249
Biological Activity
IC50: 25 nM (FPR1)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| AGS | EC50 |
10.97 μM
Compound: 24a
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Cytotoxicity against human AGS cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human AGS cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
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[PMID: 37839346] |
| AGS | EC50 |
24.7 μM
Compound: 24a
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Cytotoxicity against human AGS cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human AGS cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
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[PMID: 37839346] |
| AGS | EC50 |
7.55 μM
Compound: 24a
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Cytotoxicity against human AGS cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human AGS cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
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[PMID: 37839346] |
| NCI-N87 | EC50 |
11.5 μM
Compound: 24a
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Cytotoxicity against human NCI-N87 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human NCI-N87 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
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[PMID: 37839346] |
| NCI-N87 | EC50 |
32.9 μM
Compound: 24a
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Cytotoxicity against human NCI-N87 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human NCI-N87 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
|
[PMID: 37839346] |
| NCI-N87 | EC50 |
8.65 μM
Compound: 24a
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Cytotoxicity against human NCI-N87 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human NCI-N87 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
|
[PMID: 37839346] |
Chemical Information
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CAS No. 3053980-28-9
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Appearance Solid
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Molecular Weight 408.49
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Formula C25H28O5
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Color White to light yellow
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SMILES
CC(OC1=CC2=C(C=C1CCCCCC)C(C(C3=CC=CC=C3OC)=C(C)O2)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 200 mg/mL (489.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4480 mL | 12.2402 mL | 24.4804 mL | 61.2010 mL |
| 5 mM | 0.4896 mL | 2.4480 mL | 4.8961 mL | 12.2402 mL | |
| 10 mM | 0.2448 mL | 1.2240 mL | 2.4480 mL | 6.1201 mL | |
| 15 mM | 0.1632 mL | 0.8160 mL | 1.6320 mL | 4.0801 mL | |
| 20 mM | 0.1224 mL | 0.6120 mL | 1.2240 mL | 3.0601 mL | |
| 25 mM | 0.0979 mL | 0.4896 mL | 0.9792 mL | 2.4480 mL | |
| 30 mM | 0.0816 mL | 0.4080 mL | 0.8160 mL | 2.0400 mL | |
| 40 mM | 0.0612 mL | 0.3060 mL | 0.6120 mL | 1.5300 mL | |
| 50 mM | 0.0490 mL | 0.2448 mL | 0.4896 mL | 1.2240 mL | |
| 60 mM | 0.0408 mL | 0.2040 mL | 0.4080 mL | 1.0200 mL | |
| 80 mM | 0.0306 mL | 0.1530 mL | 0.3060 mL | 0.7650 mL | |
| 100 mM | 0.0245 mL | 0.1224 mL | 0.2448 mL | 0.6120 mL |
FPR1 antagonist 1 Related Classifications
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