1. Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
  2. Reactive Oxygen Species
  3. Randialic acid B

Randialic acid B 

Cat. No.: HY-N8152
Handling Instructions

Randialic acid B, a triterpenoid compound, is a formyl peptide receptor 1 (FPR1) antagonist. Randialic acid B blocks FPR1 in human neutrophils and attenuates psoriasis-like inflammation in vivo.

For research use only. We do not sell to patients.

Randialic acid B Chemical Structure

Randialic acid B Chemical Structure

CAS No. : 14021-14-8

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Description

Randialic acid B, a triterpenoid compound, is a formyl peptide receptor 1 (FPR1) antagonist. Randialic acid B blocks FPR1 in human neutrophils and attenuates psoriasis-like inflammation in vivo[1].

In Vitro

Randialic acid B (0.1-3 μM; for 5 min) selectively inhibits reactive oxygen species production, elastase release, and CD11b expression in human neutrophils activated by FPR1. Randialic acid B inhibits the binding of N-formyl peptide to FPR1 in human neutrophils, neutrophil-like THP-1 cells, and hFPR1-transfected HEK293 cells, indicating FPR1 antagonism[1].
Randialic acid B acts competitively for its binding to the FPR1 receptor. The FPR1-downstream signaling such as Ca2+ mobilisation and activation of Akt and MAPKs is also competitively inhibited[1].
Randialic acid B shows significant cell-protective effects against H2O2-induced H9c2 cardiomyocyte injury[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Randialic acid B (10 mg/kg; i.v.; every other day; for 5 days) significantly reduces Imiquimod-induced psoriasis-like symptom, including epidermal hyperplasia, desquamation with scaling, neutrophil skin infiltration, and transepidermal water loss[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c white female mice (20 g weight; 7-week-old) treated with Imiquimod[1]
Dosage: 10 mg/kg
Administration: i.v.; every other day; for 5 days
Result: Significantly reduced Imiquimod-induced psoriasis-like symptoms.
Molecular Weight

454.68

Formula

C₃₀H₄₆O₃

CAS No.
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Randialic acid B
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HY-N8152
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