Aquifoliaceae

Pedunculoside exerts lipid-lowering effects partly through the regulation of?lipogenesis?and?fatty acid β-oxidation.

Rotundic acid is an orally effective triterpenoid with a K_d value of 51.3 µM for PTP1B. Rotundic acid downregulates the AKT/mTOR pro-survival pathway and modulates the MAPK pathway. Rotundic acid induces cell cycle S-phase arrest, DNA damage and apoptosis; it inhibits migration, invasion, angiogenesis and proliferation of cancer cells. Rotundic acid improves leptin sensitivity, regulates gut microbiota and reduces cellular senescence. Rotundic acid can be used in research related to hepatocellular carcinoma, obesity, aging, acute lung injury and type 2 diabetes.

Ilexgenin A is a pentacyclic triterpenoid, which extracted from Ilex hainanensis Merr. Ilexgenin A can be used for the research of inflammation and cancer.

Ilexsaponin A, isolated from the root of Ilex pubescens, attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. Ilexsaponin A can reduce myocardial infarct size, lower the serum levels of LDH, AST and CK-MB, increase cellular viability and inhibit apoptosis in hypoxia/reoxygenation cardiomyocytes.

Randialic acid B, a triterpenoid compound, is a formyl peptide receptor 1 (FPR1) antagonist. Randialic acid B blocks FPR1 in human neutrophils and attenuates psoriasis-like inflammation in vivo.

Ilex chinensis polysaccharide is a polysaccharide derived from Ilex chinensis.

Ilexosapogenin A is a triterpenoid natural product aglycone. Ilexosapogenin A can be obtained from crataeguside via enzymatic hydrolysis or alkaline hydrolysis. Ilexosapogenin A can be used in studies on triterpenoid natural products, structural identification of triterpenoid glycosides, and glycoside hydrolysis.

Hylonoside I is a TMV inhibitor that inhibits the proliferation of TMV. Hylonoside I can be isolated from the leaves of Ilex hylonoma. Hylonoside I is applicable to the research of TMV infection.

Ilexhainanoside D is the main triterpenoid saponin extracted from Ilex hainanensis Merr., and the combination of Ilexhainanoside D and ilexsaponin A1 has anti-inflammation effect.

Ilexoside D is isolated from the roots of Ilex pubescens Hook. et Arn. Ilexoside D has the anti-tissue factor activity as well as the antithrombotic activity.

Brevicuspisaponin 2 is a triterpenoid glycoside saponin that can be isolated from the leaves of Ilex brevicuspis, and it is applicable to biochemical experiments and compound synthesis research.

Ilex Kudincha Extracts is derived from the tender leaves of Ilex holly and Ilex kudingcha. Ilex kudincha extract has the effects of lowering blood lipids, increasing myocardial blood supply, and anti-atherosclerosis.

19-Anhydro-4-epirotungenic acid is a triterpenoid compound that can be isolated from the bark of Ilex rotunda Thunb. 19-Anhydro-4-epirotungenic acid shows no activity against ADP-induced platelet aggregation.

Pubescenoside Q is a phenol glycoside compound that can be found in the roots of Ilex pubescens.

(2α,3β)-Dihydroxy-23-norolean-4(24),12(13)-dien-28-oic acid is a natural product that can be found in Qi Dun Guo.

Huazhongilexol is a cyano compound found in ilex centrochinensis.

Rotundic acid (Standard) is the analytical standard of Rotundic acid (HY-N2217). This product is intended for research and analytical applications. Rotundic acid is an orally effective triterpenoid with a K_d value of 51.3 µM for PTP1B. Rotundic acid downregulates the AKT/mTOR pro-survival pathway and modulates the MAPK pathway. Rotundic acid induces cell cycle S-phase arrest, DNA damage and apoptosis; it inhibits migration, invasion, angiogenesis and proliferation of cancer cells. Rotundic acid improves leptin sensitivity, regulates gut microbiota and reduces cellular senescence. Rotundic acid can be used in research related to hepatocellular carcinoma, obesity, aging, acute lung injury and type 2 diabetes.

Methyl 4-O-caffeoylquinate is an extract naturally derived from the leaf ofIlex paraguariensis. Methyl 4-O-caffeoylquinate has human neutrophilic elastase (HNE) inhibitory activity .

Ilexsaponin B3 has significant hypocholesterolemic activity.

Ilexoside XLVIII is an acyl CoA cholesteryl acyl transferase (ACAT) inhibitor. Ilexoside XLVIII is a triterpene saponin isolated from an aqueous extract of the leaves of Ilex kudincha.