1. Acids and Aldehydes
  2. Ilexgenin A

Ilexgenin A 

Cat. No.: HY-N6255
Handling Instructions

Ilexgenin A is a pentacyclic triterpenoid, which extracted from Ilex hainanensis Merr. Ilexgenin A can be used for the research of inflammation and cancer.

For research use only. We do not sell to patients.

Ilexgenin A Chemical Structure

Ilexgenin A Chemical Structure

CAS No. : 108524-94-3

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Description

Ilexgenin A is a pentacyclic triterpenoid, which extracted from Ilex hainanensis Merr. Ilexgenin A can be used for the research of inflammation and cancer[1].

In Vitro

Ilexgenin A (0~100 μM; 24 hours; HT 29 and HCT 116 cells) effectively decreases cell viability in HT 29 and HCT 116 cells[1].
Ilexgenin A (12.5~50 μM; 24 hours; HT 29 cells) downregulates the expression of SREBP-1, inhibits the translocation of SREBP-1 to the nucleus and decreases the content of TG[1].
Ilexgenin A (12.5~50 μM; HT 29 and HCT 116 cells) induces cell cycle arrest at G1 phase in colon cancer cells[1].
Ilexgenin A (12.5~50 μM; 24 hours; HCT 116 cells) modulates lipid metabolism. Ilexgenin A (50 μM; 24 hours; HT 29 and HCT 116 cells) regulates SREBP-1 by inhibiting HIF1α[1].
Ilexgenin A inhibits fatty acids synthesis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HT 29 and HCT 116 cells
Concentration: 0~100 μM
Incubation Time: 24 hours
Result: Effectively decreased cell viability in HT 29 and HCT 116 cells.

Western Blot Analysis[1]

Cell Line: HT 29 cells
Concentration: 12.5~50 μM
Incubation Time: 24 hours
Result: Downregulated the expression of SREBP-1.

RT-PCR[1]

Cell Line: HT 29 cells
Concentration: 12.5~50 μM
Incubation Time: 24 hours
Result: Decreased the content of TG.

Immunofluorescence[1]

Cell Line: HT 29 cells
Concentration: 12.5~50 μM
Incubation Time: 24 hours
Result: Inhibited the translocation of SREBP-1 to the nucleus.
In Vivo

Ilexgenin A (20 mg/kg) ameliorates the AOM/DSS induced carcinogenesis. Ilexgenin A can regulate lipid metabolism. Ilexgenin A decreases the expression of SREBP-1 and HIF 1α in AOM/DSS mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

502.68

Formula

C₃₀H₄₆O₆

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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