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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
Gαq
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "Gαq" in MCE Product Catalog:
18
18 Publications Verification
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4 Cited Publications
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Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Thyrotropin (TSH, Pretiron) is a thyroid-stimulating hormone produced by thyrotrope cells in the anterior pituitary gland. Thyrotropin regulates the endocrine function of the thyroid. Thyrotropin induces transcriptional regulation of TH-gatekeeper genes in tanycytes through the Tshr/Gαq/PKC pathway. Thyrotropin prevents Apoptosis. Thyrotropin has an association of low levels with increased bone remodeling, reduced bone mass and a high fracture risk in mice. Thyrotropin is promising for research of skeletal remodeling, hyperthyroidism .
Synonyms: PG(16:0/18:1) sodium; 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) sodium
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POPG (sodium) is a negatively charged phospholipid. POPG (sodium) affects the interactions of membrane proteins with other molecules by changing the charge characteristics of the lipid environment. POPG (sodium) increases the apparent affinity of Gαq and Gβ1γ1 for activated NTS1. POPG (sodium) can interact with the positive charge of peptides. POPG sodium salt can be used in Parkinson's disease research .
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I-287 is a orally active selective PAR2 inhibitor that acting as a negative allosteric regulator on Gαq and Gα12/13 activity and their downstream effectors. I-287 reduces Complete Freund's adjuvant (HY-153808)-induced inflammation in mice and can be used for inflammation/immunology research .
Cat. No.: HY-P3136
CAS No.: 25849-90-5
Synonyms: TRV120055
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MS437 is a potent TSH receptor (TSHR) stimulator with an EC50 value of 13x10 -8 M. MS437 shows potent activation of Gsα, Gαq and Gα12 and up-regulation of thyroglobulin (Tg), sodium iodine symporter (NIS) and TSHR gene expressions .
Cat. No.: HY-W077477
CAS No.: 313368-85-3
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IHCH-7113 is a 5-HT2AR agonist with EC50 values of 58.9 nM (Gq bioluminescence resonance energy transfer assay) and 44.7 nM (β-arrestin 2 bioluminescence resonance energy transfer assay). IHCH-7113 activates both Gαq-mediated signaling pathways and β-arrestin 2 recruitment pathways. IHCH-7113 is applicable for research related to depression .
Cat. No.: HY-P3136A
Synonyms: TRV120055 hydrochloride
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Cat. No.: HY-P3910
CAS No.: 100900-28-5
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Cat. No.: HY-120816
CAS No.: 1702378-78-6
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WU-07047, a simplified analog of YM-254890 (HY-111557), is a selective Gαq/11 inhibitor. WU-07047 can inhibit nucleotide exchange .
Cat. No.: HY-161317
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Gαq/11 protein-IN-1 (compound F33) is an inhibitor of Gαq/11 protein with an IC50 value of 9.4 μM. Gαq/11 protein-IN-1 has antitumor activity .
Cat. No.: HY-108554
CAS No.: 1052076-77-3
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Q94 hydrochloride, a selective PAR1 antagonist (IC50=916 nM), can selectively block PAR1/Gαq interaction and signalling. Q94 hydrochloride blocks PAR1-mediated increases in both CCL2 mRNA and protein levels in a dose-dependent manner. Q94 hydrochloride also completely blocks thrombin-induced ERK1/2 and MLC phosphorylation .
Cat. No.: HY-103117
CAS No.: 847871-78-7
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S 32212 hydrochloride is an inverse agonist of 5-HT receptors 5-HT2(CINI) and 5-HT2(CVSV) (Kis=6.6, 8.9 nM) and an antagonist of 5-HT2A and α2β-adrenergic receptors (Ki=5.8, 5.8 nM). S 32212 hydrochloride can reduce the binding of GTPγS to Gαq, and reduce the activity of phospholipase C (PLC) in HEK293 cells expressing 5-HT2(CINI) receptor and CHO cells expressing 5-HT2(CVSV) receptor (EC50=38 and 18.6 nM, respectively). S 32212 hydrochloride (2.5 mg/kg) reduces 5-HT receptor agonist-induced head twitches and penile erections in mice and rats. S 32212 hydrochloride (10, 40 mg/kg) reduces immobility time in the forced swim test and marble burying behavior in mice and rats, exerting antidepressant and anxiolytic activities.
Cat. No.: HY-179165
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Gαq/11 protein-IN-2 (Compound 9g) is a Gαq/11 protein inhibitor, with an IC50 of 11.3 μM. Gαq/11 protein-IN-2 induces Apoptosis, increases p-YAP. Gαq/11 protein-IN-2 has anticancer activity against uveal melanoma .
Cat. No.: HY-182405
CAS No.: 2625582-70-7
GQ127 is an orally active Gαq/11 inhibitor with an IC50 of 22.6 μM. GQ127 binds directly to Gαq/11 protein and inhibits its activity. GQ127 induces Apoptosis, suppresses viability, migration and invasion of uveal melanoma cells. GQ127 increases the phosphorylation level of YAP and decreases the phosphorylation level of ERK. GQ127 inhibits the growth of uveal melanoma xenografts in mouse models. GQ127 can be used for research related to uveal melanoma .
Cat. No.: HY-N17826
CAS No.: 726188-99-4
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Cat. No.: HY-P11866
CAS No.: 16376-83-3
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Cat. No.: HY-115643
CAS No.: 2896777-27-6
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AZ13581837 is an orally active GPR120 agonist with an EC50 of 5.2 nM for human GPR120. AZ13581837 signals through Gαq, Gαs, and β-arrestin pathways, reduces cAMP production, stimulates GLP-1 secretion, induces glucose lowering, and increases insulin secretion. AZ13581837 can be used for the research of type 2 diabetes .
Cat. No.: HY-178787S
Synonyms: PG(16:0/18:1)-d62; 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol)-d62
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
