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Glucose-6-Phosphate Isomerase

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標的別:	Glucose-6-Phosphate Isomerase (GPI) (2) Biochemical Assay Reagents (1) Endogenous Metabolite (3) Hexokinase (2) TNF Receptor (1)
研究分野別:	Cancer (3) Inflammation/Immunology (1) Metabolic Disease (3)

阻害剤およびアゴニスト

スクリーニングライブラリ

生化学アッセイ試薬

組換えタンパク質

抗体

Targets Recommended: Glucose-6-Phosphate Isomerase (GPI) Phosphomannose Isomerase (PMI) PIN1

製品番号	製品名	Target	研究分野	構造式

HY-139409A

2-Deoxy-D-glucose 6-phosphate disodium 2 Publications Verification	Hexokinase Glucose-6-Phosphate Isomerase (GPI)	Cancer
2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive, 2-deoxy-D-glucose non-competitive Hexokinase inhibitor, with a K_i value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the production and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and **Glucose-6-phosphate isomerase*, and inducing cell death. 2-Deoxy-D-glucose* 6-phosphate disodium can be used in cancer-related research .

HY-P2918

Phosphoglucose Isomerase, Rabbit muscle GPI; PhosphoGlucose Isomerase	Endogenous Metabolite	Metabolic Disease Cancer
Phosphoglucose Isomerase, Rabbit muscle (GPI), i.e., phosphoglucose isomerase/phosphoglucoisomerase (PGI) or phosphohexose isomerase (PHI), is often used in biochemical studies. Glucose 6-phosphate isomeras is a highly conserved glycolytic and dimeric enzyme. Glucose 6-phosphate isomeras catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate .

HY-167805

D-Glucose 6-phosphate potassium	Biochemical Assay Reagents
D-Glucose 6-phosphate potassium is a biologically active compound that has the activity of being a substrate for glucose-6-phosphate isomerase. D-Glucose 6-phosphate potassium can participate in the sugar metabolism process and promote the production and utilization of energy in cells.

HY-139409

2-Deoxy-D-glucose 6-phosphate	Hexokinase Glucose-6-Phosphate Isomerase (GPI)	Cancer
2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive and 2-deoxy-D-glucose non-competitive Hexokinase inhibitor, with a K_i value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the generation and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and **Glucose-6-phosphate isomerase*, and inducing cell death. 2-Deoxy-D-glucose* 6-phosphate disodium can be used in cancer-related research .

HY-175250

TNF-α-IN-25	TNF Receptor	Inflammation/Immunology
TNF-α-IN-25 is an orally active TNF-α inhibitor. TNF-α-IN-25 shows Fluorescence Polarization (FP) assay IC₅₀ of 103 nM in FP binding assays and L929 assay IC₅₀ of 505 nM in cell-based assays. TNF-α-IN-25 inhibits paw swelling in the glucose-6-phosphate isomerase (GPI) arthritis model. TNF-α-IN-25 can be used for the study of arthritis .

HY-P2918B

Phosphoglucose isomerase, Baker's Yeast	Endogenous Metabolite	Metabolic Disease
Phosphoglucose isomerase, bacillus stearothermophilus is a highly conserved glycolytic and dimeric enzyme. Phosphoglucose isomerase, bacillus stearothermophilus catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate .

HY-P2918A

Phosphoglucose isomerase, bacillus stearothermophilus	Endogenous Metabolite	Metabolic Disease
Phosphoglucose isomerase, bacillus stearothermophilus is a highly conserved glycolytic and dimeric enzyme. Phosphoglucose isomerase, bacillus stearothermophilus catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate .

製品番号	製品名

HY-L058

Glycolysis Compound Library	1,258 compounds
Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation. Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications. MCE provides a unique collection of 1,258 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

Glycolysis Compound Library

1,258 compounds

Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation.

Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications.

MCE provides a unique collection of 1,258 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

製品番号	製品名	Type

HY-167805

D-Glucose 6-phosphate potassium	生化学アッセイ試薬
D-Glucose 6-phosphate potassium is a biologically active compound that has the activity of being a substrate for glucose-6-phosphate isomerase. D-Glucose 6-phosphate potassium can participate in the sugar metabolism process and promote the production and utilization of energy in cells.

Species:	Human (1) Mouse (2)
Tag:	His (3) B2M (1)
Source:	P. pastoris (1) E. coli (2)

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HY-P71738

	Glucose-6-phosphate isomerase Protein, Mouse (P.pastoris, His) Gpi; Gpi1Glucose-6-Phosphate Isomerase; GPI; AMF; Neuroleukin; NLK; PHI	Mouse	P. pastoris
	Glucose-6-phosphate isomerase protein exists in the cytoplasm and has dual functions. It converts glucose-6-phosphate into fructose-6-phosphate, playing a vital role in glycolysis and gluconeogenesis. Glucose-6-phosphate isomerase Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Glucose-6-phosphate isomerase protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P72210

	Glucose-6-phosphate isomerase Protein, Mouse (His-B2M) Gpi; Gpi1Glucose-6-Phosphate Isomerase; GPI; EC 5.3.1.9; Autocrine motility factor; AMF; Neuroleukin; NLK; PhosphoGlucose Isomerase; PGI; Phosphohexose Isomerase; PHI	Mouse	E. coli
	Glucose-6-phosphate isomerase protein exists in the cytoplasm and has dual functions. It converts glucose-6-phosphate into fructose-6-phosphate, playing a vital role in glycolysis and gluconeogenesis. Glucose-6-phosphate isomerase Protein, Mouse (His-B2M) is the recombinant mouse-derived Glucose-6-phosphate isomerase protein, expressed by E. coli , with N-6*His, B2M labeled tag.

HY-P71680

	Glucose-6-phosphate isomerase Protein, Human (His) AMF; Aurocrine motility factor; Autocrine motility factor; DKFZp686C13233; EC 5.3.1.9; Neuroleukin; NLK; OxoIsomerase; PGI; PHI; PhosphoGlucose Isomerase; SA-36; SA36; Sperm antigen 36	Human	E. coli
	Glucose-6-phosphate isomerase protein is a key player in glycolysis, catalyzing the conversion of glucose-6-phosphate into fructose-6-phosphate in the cytoplasm. It carries out this reaction reversibly during gluconeogenesis. Glucose-6-phosphate isomerase Protein, Human (His) is the recombinant human-derived Glucose-6-phosphate isomerase protein, expressed by E. coli , with N-6*His labeled tag.

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Host:	Mouse (3) Rabbit (2)
Reactivity:	Human (5)
Application:	IHC-P (5) ICC/IF (5) IF-Tissue (1) WB (3) FC (2) ELISA (3)
Isotype:	IgG (2) IgG1 (2)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (3) Recombinant (1)
Modification:	Unmodified (4)

製品番号	Compare	製品名	Application	Reactivity	Image

HY-P85191

	AMF Antibody (YA4883) GPI; Glucose-6-Phosphate Isomerase; GPI; Autocrine motility factor; AMF; Neuroleukin; NLK; PhosphoGlucose Isomerase; PGI; Phosphohexose Isomerase; PHI; Sperm antigen 36; SA-36	WB, IHC-P, ICC/IF, ELISA	Human
	AMF Antibody (YA4883) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to AMF.

HY-P82032

	AMF Antibody (YA1777) GPI; Glucose-6-Phosphate Isomerase; GPI; Autocrine motility factor; AMF; Neuroleukin; NLK; PhosphoGlucose Isomerase; PGI; Phosphohexose Isomerase; PHI; Sperm antigen 36; SA-36	WB, IHC-P, ICC/IF, FC	Human
	AMF Antibody (YA1777) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AMF.

HY-P83978

	Glucose-6-phosphate isomerase Antibody (YA3675) AMF; NLK; PGI; PHI; GNPI; SA-36; GPI	IHC-P, ICC/IF, ELISA	Human
	Glucose-6-phosphate isomerase Antibody (YA3675) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Glucose-6-phosphate isomerase.

HY-P83978A

	Glucose-6-phosphate isomerase Antibody (YA3675)(PBS only) AMF; NLK; PGI; PHI; GNPI; SA-36; GPI	IHC-P, ICC/IF, ELISA	Human
	Glucose-6-phosphate isomerase Antibody (YA3675) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Glucose-6-phosphate isomerase.

HY-P810641

	Glucose 6 phosphate isomerase Antibody (YA9903) GPI; Glucose-6-Phosphate Isomerase; GPI; Autocrine motility factor; AMF; Neuroleukin; NLK; PhosphoGlucose Isomerase; PGI; Phosphohexose Isomerase; PHI; Sperm antigen 36; SA-36	WB, IHC-P, FC, ICC/IF, IF-Tissue	Human
	Glucose 6 phosphate isomerase Antibody (YA9903) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Glucose 6 phosphate isomerase.

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