2-Deoxy-D-glucose 6-phosphate disodium
Based on 2 publication(s) in Google Scholar
2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive, 2-deoxy-D-glucose non-competitive Hexokinase inhibitor, with a Ki value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the production and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and Glucose-6-phosphate isomerase, and inducing cell death. 2-Deoxy-D-glucose 6-phosphate disodium can be used in cancer-related research.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 33068-19-8
- Formula: C6H11Na2O8P
- Molecular Weight:288.10
-
Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 2-Deoxy-D-glucose 6-phosphate disodium
More
Biological Activity
2-deoxy-D-glucose 6-phosphate disodium inhibits 2DG phosphorylation catalyzed by bovine heart hexokinase via competitive inhibition of ATP and non-competitive inhibition of 2DG, with an average inhibition constant of 1.45 mM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 33068-19-8
-
Appearance Solid
-
Molecular Weight 288.10
-
Formula C6H11Na2O8P
-
Color White to off-white
-
SMILES
O=P(O[Na])(O[Na])OC[C@@H](O)[C@@H](O)[C@H](O)CC=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Anal Chem
Streamlined Methods for Profiling Targeted Michael Acceptor Molecules Reveal Natural PTP1B Covalent Inhibitors. [Abstract]2025 Oct 1. PMID: 41035255 -
Toxicol Appl Pharmacol
Exploring the potential use of Caenorhabditis elegans as an animal model for evaluating chemical-induced intestinal dysfunction. [Abstract]2024 Dec:493:117140. PMID: 39500396
Solvent & Solubility
H2O : 175 mg/mL (607.43 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Chen W, et al. The inhibition of bovine heart hexokinase by 2-deoxy-D-glucose-6-phosphate: characterization by 31P NMR and metabolic implications. Biochimie. 1992;74(9-10):867-873. [Content Brief]
[2]. Pajak B, et al. 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents. Int J Mol Sci. 2019;21(1):234. Published 2019 Dec 29. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.4710 mL | 17.3551 mL | 34.7102 mL | 86.7754 mL |
| 5 mM | 0.6942 mL | 3.4710 mL | 6.9420 mL | 17.3551 mL | |
| 10 mM | 0.3471 mL | 1.7355 mL | 3.4710 mL | 8.6775 mL | |
| 15 mM | 0.2314 mL | 1.1570 mL | 2.3140 mL | 5.7850 mL | |
| 20 mM | 0.1736 mL | 0.8678 mL | 1.7355 mL | 4.3388 mL | |
| 25 mM | 0.1388 mL | 0.6942 mL | 1.3884 mL | 3.4710 mL | |
| 30 mM | 0.1157 mL | 0.5785 mL | 1.1570 mL | 2.8925 mL | |
| 40 mM | 0.0868 mL | 0.4339 mL | 0.8678 mL | 2.1694 mL | |
| 50 mM | 0.0694 mL | 0.3471 mL | 0.6942 mL | 1.7355 mL | |
| 60 mM | 0.0579 mL | 0.2893 mL | 0.5785 mL | 1.4463 mL | |
| 80 mM | 0.0434 mL | 0.2169 mL | 0.4339 mL | 1.0847 mL | |
| 100 mM | 0.0347 mL | 0.1736 mL | 0.3471 mL | 0.8678 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
2-Deoxy-D-glucose 6-phosphate disodium Related Classifications
HY-139409A Related Classifications
Powered by Bioz