α-D-Glucose 1,6-bisphosphate tetrapotassium
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α-D-Glucose 1,6-bisphosphate tetrapotassium is an activator of PMM2 and phosphoglucomutase. α-D-Glucose 1,6-bisphosphate tetrapotassium regulates glycogen metabolism, glycolysis, amino sugar synthesis, as well as the formation of bacterial cell walls and capsules. α-D-Glucose 1,6-bisphosphate tetrapotassium can be used in studies related to pmm2-cdg (cdg-1a or Jaeken syndrome).
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- Pureza : 98.74%
- No. CAS: 91183-87-8
- Fòrmula: C6H10K4O12P2
- Peso molecular:492.48
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Almacenamiento:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
In Vitro
α-D-Glucose 1,6-bisphosphate (1-100 μM) tetrapotassium potently activates the Sll0726 phosphoglucomutase from Synechocystis sp. PCC 6803, achieving a maximum 5-fold activation effect at concentrations ranging from 30 to 60 μM[1].
α-D-Glucose 1,6-bisphosphate (2-50 μM) tetrapotassium acts as a high-affinity substrate for Synechocystis sp. PCC 6803 Slr1334 to participate in the reverse reaction and generate Frc-1,6-BP, with a Km < 0.002 mM and a catalytic efficiency > 600,000 M-1s-1[1].
α-D-Glucose 1,6-bisphosphate (27 µM) tetrapotassium activates wild-type PMM2 activity, thereby promoting the efficient conversion of α-D-glucose-1-phosphate to glucose-6-phosphate[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 91183-87-8
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Appearance Solid
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Peso molecular 492.48
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Fòrmula C6H10K4O12P2
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Color White to off-white
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SMILES
O=P(O[K])(O[K])OC[C@H]1O[C@@H]([C@@H]([C@H]([C@@H]1O)O)O)OP(O[K])(O[K])=O
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Structure Classification
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Initial Source
Human Blood
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvente y solubilidad
In Vitro:
H2O : 100 mg/mL (203.05 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (287 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Neumann N, et al. Glucose-1,6-Bisphosphate, a Key Metabolic Regulator, Is Synthesized by a Distinct Family of α-Phosphohexomutases Widely Distributed in Prokaryotes. mBio. 2022;13(4):e0146922. [Content Brief]
[2]. Monticelli M, et al. β-Glucose-1,6-Bisphosphate Stabilizes Pathological Phophomannomutase2 Mutants In Vitro and Represents a Lead Compound to Develop Pharmacological Chaperones for the Most Common Disorder of Glycosylation, PMM2-CDG. Int J Mol Sci. 2019;20(17):4164. Published 2019 Aug 26. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.0305 mL | 10.1527 mL | 20.3054 mL | 50.7635 mL |
| 5 mM | 0.4061 mL | 2.0305 mL | 4.0611 mL | 10.1527 mL | |
| 10 mM | 0.2031 mL | 1.0153 mL | 2.0305 mL | 5.0763 mL | |
| 15 mM | 0.1354 mL | 0.6768 mL | 1.3537 mL | 3.3842 mL | |
| 20 mM | 0.1015 mL | 0.5076 mL | 1.0153 mL | 2.5382 mL | |
| 25 mM | 0.0812 mL | 0.4061 mL | 0.8122 mL | 2.0305 mL | |
| 30 mM | 0.0677 mL | 0.3384 mL | 0.6768 mL | 1.6921 mL | |
| 40 mM | 0.0508 mL | 0.2538 mL | 0.5076 mL | 1.2691 mL | |
| 50 mM | 0.0406 mL | 0.2031 mL | 0.4061 mL | 1.0153 mL | |
| 60 mM | 0.0338 mL | 0.1692 mL | 0.3384 mL | 0.8461 mL | |
| 80 mM | 0.0254 mL | 0.1269 mL | 0.2538 mL | 0.6345 mL | |
| 100 mM | 0.0203 mL | 0.1015 mL | 0.2031 mL | 0.5076 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
α-D-Glucose 1,6-bisphosphate tetrapotassium Related Classifications
HY-N8365 Related Classifications
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Keywords
- α-D-Glucose 1,6-bisphosphate tetrapotassium
- 91183-87-8
- Phosphomannose Isomerase (PMI)
- phosphomannomutase2
- Synechocystis sp. PCC 6803
- bacterial cell wall
- phosphomannomutase
- inosine monophosphate
- α-D-phosphohexomutase
- amino sugar formation
- glycolysis
- phosphomannomutase1
- glycogen metabolism
- Inhibitor
- inhibitor
- inhibit