α-D-Glucose 1,6-bisphosphate
α-D-Glucose 1,6-bisphosphate is an activator of PMM2 and phosphoglucomutase. α-D-Glucose 1,6-bisphosphate regulates glycogen metabolism, glycolysis, amino sugar synthesis, as well as the formation of bacterial cell walls and capsules. α-D-Glucose 1,6-bisphosphate can be used in studies related to pmm2-cdg (cdg-1a or Jaeken syndrome).
For research use only. We do not sell to patients.
- CAS No.: 10139-18-1
- Formula: C6H14O12P2
- Molecular Weight:340.12
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Human Endogenous Metabolite |
α-D-Glucose 1,6-bisphosphate (1-100 μM) potently activates the Sll0726 phosphoglucomutase from Synechocystis sp. PCC 6803, achieving a maximum 5-fold activation effect at concentrations ranging from 30 to 60 μM[1].
α-D-Glucose 1,6-bisphosphate (2-50 μM) acts as a high-affinity substrate for Synechocystis sp. PCC 6803 Slr1334 to participate in the reverse reaction and generate Frc-1,6-BP, with a Km < 0.002 mM and a catalytic efficiency > 600,000 M-1s-1[1].
α-D-Glucose 1,6-bisphosphate (27 µM) activates wild-type PMM2 activity, thereby promoting the efficient conversion of α-D-glucose-1-phosphate to glucose-6-phosphate[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 10139-18-1
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Molecular Weight 340.12
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Formula C6H14O12P2
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SMILES
O=P(O)(OC[C@H]1O[C@H](OP(O)(O)=O)[C@@H]([C@H]([C@@H]1O)O)O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Neumann N, et al. Glucose-1,6-Bisphosphate, a Key Metabolic Regulator, Is Synthesized by a Distinct Family of α-Phosphohexomutases Widely Distributed in Prokaryotes. mBio. 2022;13(4):e0146922. [Content Brief]
[2]. Monticelli M, et al. β-Glucose-1,6-Bisphosphate Stabilizes Pathological Phophomannomutase2 Mutants In Vitro and Represents a Lead Compound to Develop Pharmacological Chaperones for the Most Common Disorder of Glycosylation, PMM2-CDG. Int J Mol Sci. 2019;20(17):4164. Published 2019 Aug 26. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
α-D-Glucose 1,6-bisphosphate Related Classifications
HY-113002 Related Classifications
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