10139-18-1
Chemical Structure
α-D-Glucose 1,6-bisphosphate
- CAS No.: 10139-18-1
- Formula:C6H14O12P2
- Molecular Weight:340.12
IUPAC Name: ((2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(phosphonooxy)tetrahydro-2H-pyran-2-yl)methyl dihydrogen phosphate
InChIKey: RWHOZGRAXYWRNX-VFUOTHLCSA-N
SMILES: O=P(O)(OC[C@H]1O[C@H](OP(O)(O)=O)[C@@H]([C@H]([C@@H]1O)O)O)O
Biological Activity: α-D-Glucose 1,6-bisphosphate is an activator of PMM2 and phosphoglucomutase. α-D-Glucose 1,6-bisphosphate regulates glycogen metabolism, glycolysis, amino sugar synthesis, as well as the formation of bacterial cell walls and capsules. α-D-Glucose 1,6-bisphosphate can be used in studies related to pmm2-cdg (cdg-1a or Jaeken syndrome)[1][2].
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α-D-Glucose 1,6-bisphosphate | α-D-Glucose 1,6-bisphosphate is an activator of PMM2 and phosphoglucomutase. α-D-Glucose 1,6-bisphosphate regulates glycogen metabolism, glycolysis, amino sugar synthesis, as well as the formation of bacterial cell walls and capsules. α-D-Glucose 1,6-bisphosphate can be used in studies related to pmm2-cdg (cdg-1a or Jaeken syndrome). | |||||||||||||||||||||
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References
- [1]. Neumann N, et al. Glucose-1,6-Bisphosphate, a Key Metabolic Regulator, Is Synthesized by a Distinct Family of α-Phosphohexomutases Widely Distributed in Prokaryotes. mBio. 2022;13(4):e0146922. [Content Brief]
- [2]. Monticelli M, et al. β-Glucose-1,6-Bisphosphate Stabilizes Pathological Phophomannomutase2 Mutants In Vitro and Represents a Lead Compound to Develop Pharmacological Chaperones for the Most Common Disorder of Glycosylation, PMM2-CDG. Int J Mol Sci. 2019;20(17):4164. Published 2019 Aug 26. [Content Brief]
