33068-19-8
Chemical Structure
2-Deoxy-D-glucose 6-phosphate disodium
- CAS No.: 33068-19-8
- Formula:C6H11Na2O8P
- Molecular Weight:288.10
IUPAC Name: sodium (2R,3S,4R)-2,3,4-trihydroxy-6-oxohexyl phosphate
InChIKey: OKITYZJBWJMLMD-SYDFPMGNSA-L
SMILES: O=P(O[Na])(O[Na])OC[C@@H](O)[C@@H](O)[C@H](O)CC=O
Biological Activity: 2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive, 2-deoxy-D-glucose non-competitive Hexokinase inhibitor, with a Ki value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the production and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and Glucose-6-phosphate isomerase, and inducing cell death. 2-Deoxy-D-glucose 6-phosphate disodium can be used in cancer-related research[1][2].
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2-Deoxy-D-glucose 6-phosphate disodium | 98.0% | 2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive, 2-deoxy-D-glucose non-competitive Hexokinase inhibitor, with a Ki value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the production and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and Glucose-6-phosphate isomerase, and inducing cell death. 2-Deoxy-D-glucose 6-phosphate disodium can be used in cancer-related research. | ||||||||||||||||||||
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- [1]. Chen W, et al. The inhibition of bovine heart hexokinase by 2-deoxy-D-glucose-6-phosphate: characterization by 31P NMR and metabolic implications. Biochimie. 1992;74(9-10):867-873. [Content Brief]
- [2]. Pajak B, et al. 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents. Int J Mol Sci. 2019;21(1):234. Published 2019 Dec 29. [Content Brief]
