D-Fructose 1-phosphate disodium 

D-Fructose 1-phosphate disodium is a key intermediate metabolite in the fructose metabolic pathway. As a key signaling molecule linking fructose metabolism and glucose metabolic regulation, D-Fructose 1-phosphate disodium acts as an allosteric modulator to counteract the inhibitory effect of the glucokinase-regulatory protein complex, thereby finely regulating the direction of hepatic glucose metabolism at the substrate level^[1][2].

D-Fructose 1-phosphate disodium stimulates glucokinase activity in isolated hepatocytes from fed rats, with a half-maximal effective dose of 30 pmol/mg protein; glucagon attenuates this stimulatory effect^[1].
D-Fructose 1-phosphate disodium (1 mM) is a specific substrate of *Clostridioides difficile* fructose-1-phosphate kinase, with a K_m value of 160 μM, and it is inhibited by sulfate and phosphate ions^[1].
D-Fructose 1-phosphate disodium directly dissociates the rat liver GKRP-GCK complex and relieves the GKRP-mediated inhibition of GCK^[2].
D-Fructose 1-phosphate disodium inhibits PKM2 in intestinal epithelial cells, thereby driving HIF-1α activation, hypoxic cell survival, villus elongation, and enhanced nutrient absorption^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

304.10

C₆H₁₁Na₂O₉P

71662-09-4

Liquid

Colorless to light yellow

O[C@H](C(COP(O[Na])(O[Na])=O)=O)[C@@H]([C@@H](CO)O)O

Room temperature in continental US; may vary elsewhere.

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

• [1]. Davies DR, et al. Fructose 1-phosphate and the regulation of glucokinase activity in isolated hepatocytes. Eur J Biochem. 1990;192(2):283-289.  [Content Brief]

  [2]. Brouwers MCGJ, et al. Fructose 1-phosphate, an evolutionary signaling molecule of abundancy. Trends Endocrinol Metab. 2022;33(10):680-689.  [Content Brief]