D-Fructose 1-phosphate
Based on 1 publication(s) in Google Scholar
D-Fructose 1-phosphate is a key intermediate metabolite in the fructose metabolic pathway. As a key signaling molecule linking fructose metabolism and glucose metabolic regulation, D-Fructose 1-phosphate acts as an allosteric modulator to counteract the inhibitory effect of the glucokinase-regulatory protein complex, thereby finely regulating the direction of hepatic glucose metabolism at the substrate level.
The free form of the compound is prone to instability, it is advisable to consider the stable salt form (D-Fructose 1-phosphate disodium) that retains the same biological activity.
For research use only. We do not sell to patients.
- CAS No.: 15978-08-2
- Formula: C6H13O9P
- Molecular Weight:260.14
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) D-Fructose 1-phosphate
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Description
IC50 & Target
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Human Endogenous Metabolite |
In Vitro
D-Fructose 1-phosphate stimulates glucokinase activity in isolated hepatocytes from fed rats, with a half-maximal effective dose of 30 pmol/mg protein; glucagon attenuates this stimulatory effect[1].
D-Fructose 1-phosphate (1 mM) is a specific substrate of *Clostridioides difficile* fructose-1-phosphate kinase, with a Km value of 160 μM, and it is inhibited by sulfate and phosphate ions[1].
D-Fructose 1-phosphate directly dissociates the rat liver GKRP-GCK complex and relieves the GKRP-mediated inhibition of GCK[2].
D-Fructose 1-phosphate inhibits PKM2 in intestinal epithelial cells, thereby driving HIF-1α activation, hypoxic cell survival, villus elongation, and enhanced nutrient absorption[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 15978-08-2
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Molecular Weight 260.14
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Formula C6H13O9P
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SMILES
O[C@H](C(COP(O)(O)=O)=O)[C@@H]([C@@H](CO)O)O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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BMC Microbiol
Unveiling the fructose metabolism system in Staphylococcus aureus: insights into the regulatory role of FruR and the FruRKT operon in bacterial fitness. [Abstract]2024 Jan 4;24(1):13. PMID: 38177984
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Davies DR, et al. Fructose 1-phosphate and the regulation of glucokinase activity in isolated hepatocytes. Eur J Biochem. 1990;192(2):283-289. [Content Brief]
[2]. Brouwers MCGJ, et al. Fructose 1-phosphate, an evolutionary signaling molecule of abundancy. Trends Endocrinol Metab. 2022;33(10):680-689. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
D-Fructose 1-phosphate Related Classifications
HY-112253 Related Classifications
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Keywords
- D-Fructose 1-phosphate
- 15978-08-2
- Endogenous Metabolite
- glucokinase
- cardiovascular disease
- polycystic ovary syndrome
- pyruvate kinase M2 isoform
- hypoxia-inducible factor-1α
- glucokinase regulatory protein
- Clostridium difficile
- fructose 6-phosphate
- nonalcoholic fatty liver disease
- colorectal cancer
- Inhibitor
- inhibitor
- inhibit