15978-08-2
Chemical Structure
D-Fructose 1-phosphate
- No. CAS: 15978-08-2
- Formula:C6H13O9P
- Molecular Weight:260.14
IUPAC Name: (3S,4R,5R)-3,4,5,6-tetrahydroxy-2-oxohexyl dihydrogen phosphate
InChIKey: ZKLLSNQJRLJIGT-UYFOZJQFSA-N
SMILES: O[C@H](C(COP(O)(O)=O)=O)[C@@H]([C@@H](CO)O)O
Biological Activity: D-Fructose 1-phosphate is a key intermediate metabolite in the fructose metabolic pathway. As a key signaling molecule linking fructose metabolism and glucose metabolic regulation, D-Fructose 1-phosphate acts as an allosteric modulator to counteract the inhibitory effect of the glucokinase-regulatory protein complex, thereby finely regulating the direction of hepatic glucose metabolism at the substrate level[1][2].
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D-Fructose 1-phosphate | D-Fructose 1-phosphate is a key intermediate metabolite in the fructose metabolic pathway. As a key signaling molecule linking fructose metabolism and glucose metabolic regulation, D-Fructose 1-phosphate acts as an allosteric modulator to counteract the inhibitory effect of the glucokinase-regulatory protein complex, thereby finely regulating the direction of hepatic glucose metabolism at the substrate level. | |||||||||||||||||||||
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References
- [1]. Davies DR, et al. Fructose 1-phosphate and the regulation of glucokinase activity in isolated hepatocytes. Eur J Biochem. 1990;192(2):283-289. [Content Brief]
- [2]. Brouwers MCGJ, et al. Fructose 1-phosphate, an evolutionary signaling molecule of abundancy. Trends Endocrinol Metab. 2022;33(10):680-689. [Content Brief]
